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NEX 400mcg Injection

Prescription Required

Salt Composition : Naloxone Hcl


Origin of Medicine : India

MRP: 96
Price :82
You Save :14 (15%)

1 Ampoule(s) Of 1ml

Out of Stock

Introduction to Nex 400mcg Injection

NEX 400mcg Injection contains an active component called Naloxone HCL. It is a medication used to reverse opioid overdose rapidly. In cases where children or individuals without opioid tolerance accidentally ingest opioids, it may be administered to reverse the effects and prevent respiratory depression. It may be used in neonatal intensive care units (NICUs) to treat newborns who experience withdrawal symptoms due to opioid exposure in utero. It is sometimes used in medication-assisted treatment (MAT) programs for individuals with opioid use disorder. 

Individuals with a known allergy or hypersensitivity to NEX 400mcg Injection or any of its components should not receive this medication. It should not be administered to individuals who are not suspected of having an opioid overdose. It can be used in children, especially if they have accidentally ingested opioids.  NEX 400mcg Injection can be used in elderly individuals, like adults, but age-related factors may affect the response to this medication. It should be administered as needed in cases of opioid overdose, with proper monitoring.

Uses of Nex 400mcg Injection

NEX 400mcg Injection is used in the following:

  • Reversal of opioid overdose
  • Neonatal abstinence syndrome (NAS)
  • Combination with opioid maintenance therapy
  • Pain management reversal

Therapeutic Effects of Nex 400mcg Injection

NEX 400mcg Injection is an opioid receptor antagonist that competitively binds to and blocks the activity of opioid receptors in the central nervous system. By displacing opioids like heroin, morphine, or fentanyl from these receptors, it rapidly reverses the effects of opioids, including respiratory depression, sedation, and analgesia. This competitive binding restores normal respiratory function and consciousness, making it a life-saving intervention in opioid overdose situations. 

Interaction of Nex 400mcg Injection with other drugs

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with NEX 400mcg Injection, reducing effectiveness by causing undesirable side effects. 

More Information about Nex 400mcg Injection

  • Store at room temperature, between 20-25°C
  • Keep away from moisture, heat, and light.
  • It should not be frozen.
  • Keep away from children and pets.

How to consume Nex 400mcg Injection

NEX 400mcg injection is administered intravenously (IV), intramuscularly (IM), intranasally (through the nose), or subcutaneously (under the skin). The choice of administration route may depend on the situation and the training level of the person providing the medication.

Safety Advices for Nex 400mcg Injection

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NEX 400mcg Injection should be used during pregnancy only if the potential benefits outweigh the potential risks to the fetus. It is essential to consult your healthcare provider before taking this medication.

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Breast Feeding


The amount of NEX 400mcg Injection transferred to the baby through breast milk is minimal compared to the benefits of treating an overdose. However, it's essential to consult your healthcare provider before taking this medication.

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If you have any lung disease, it is advisable to consult your healthcare provider before taking NEX 400mcg Injection.

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NEX 400mcg Injection is primarily metabolized in the liver, so individuals with severe liver impairment should consult a healthcare provider before taking this medication.

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NEX 400mcg injection is specific to opioid overdoses and does not affect alcohol intoxication. It should not be used as a treatment for alcohol overdose or intoxication. Always consult a healthcare provider before taking this medication with alcohol.

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NEX 400mcg injection does not typically impair cognitive or motor function. If you experience any side effects that affect your ability to drive or operate machinery, consult your healthcare provider.

Side Effects of Nex 400mcg Injection

NEX 400mcg Injection causes some side effects like all medications, although not everyone will experience them. 


  • Opioid withdrawal


  • Nasal irritation
  • Increased heart rate
  • Nausea or vomiting
  • Sweating
  • Restlessness or agitation
  • Muscle aches or pains
  • Hypertension (high blood pressure)

Word of Advice

Those administering NEX 400mcg Injection should be prepared to manage withdrawal symptoms if they occur. When using it as a nasal spray, ensure the nozzle is not obstructed and the spray is delivered correctly into the nostrils for optimal effectiveness. In cases of severe opioid overdose, multiple doses of naloxone may be necessary due to the duration of action of some opioids. This should be done under medical supervision, as its effects can wear off before the opioids have cleared the system. It should not be used if it is past its expiration date, as expired medication may not be as effective in reversing an overdose.  Be aware of any allergies to this medication. Recognize that individual responses to this medication may vary; some require higher or more frequent doses. 


Q 1. What should I do after administering the NEX 400mcg Injection?

After giving NEX 400mcg Injection, seek immediate medical attention for the person who overdosed, as the effects of this medication can wear off before the opioids have cleared the system.

Q 2. How quickly does NEX 400mcg Injection work?

NEX 400mcg Injection usually takes effect within minutes when administered properly, but its duration of action can be shorter than some opioids. Repeat doses may be necessary.

Q 3. Can I harm someone by giving them a NEX 400mcg Injection if it's not an opioid overdose?

NEX 400mcg Injection is specific to opioids and is not harmful if administered to someone who is not experiencing an opioid overdose. It will have no effect in such cases.

Q 4. What should I do if the person doesn't respond to the NEX 400mcg Injection?

If the person does not respond to the NEX 400mcg Injection or their symptoms return after a brief improvement, administer another dose and seek immediate medical attention. It's important to monitor the individual closely.

Q 5. Can I get an NEX 400mcg Injection without a prescription?

In many places, NEX 400mcg Injection is available without a prescription. It may be obtained through pharmacies, harm reduction programs, or distribution initiatives.

Q 6. Are there any side effects for the person receiving NEX 400mcg Injection?

The primary side effect of NEX 400mcg Injection for the person receiving it is the induction of opioid withdrawal symptoms, which can be uncomfortable but are typically not life-threatening.

Fact Box of Nex 400mcg Injection

Molecule name: Naloxone HCL    

Therapeutic class: Opioid Overdose Reversal Agents

Pharmacological class: Opioid Receptor Antagonists


1. Reversal of opioid overdose

2. Neonatal abstinence syndrome (NAS)

3. Combination with opioid maintenance therapy

4. Pain management reversal


  1. Mercury Pharma International Ltd, Electronic Medicines Compendium (EMC), [Revised on 19th Nov 2019] [Accessed on 27th Sept 2023],
  2. Christian Lüscher, Drugs of Abuse, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 575-589.


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