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Nexlead-D40 Capsule

Prescription Required

Salt Composition : Esomeprazole & Domperidone


Origin of Medicine : India

MRP: 99.9
Price :85
You Save :15 (15%)

10 Capsule(s) In A Strip

Delivery By -

Introduction to Nexlead-d40 Capsule

Nexlead-d40 capsule is a combination medication that belongs to the proton pump inhibitors (PPIs) and dopamine antagonists category containing the active ingredients esomeprazole and domperidone. This drug treats conditions such as gastroesophageal reflux disease (in which the stomach acid and contents flow back into the esophagus), peptic ulcers (a sore or erosion that forms on the stomach lining), and nausea and vomiting.

This medicine is contraindicated in people with a history of cardiac arrhythmias such as ventricular fibrillation, ventricular tachycardia, or QT prolongation or in those taking medications that prolong the QT interval. This  may cause side effects such as dizziness, drowsiness, or vision changes in some individuals. If these effects occur, avoiding activities requiring alertness, such as driving, cycling, or operating machinery, is important until you feel better.

Long-term use of this medicine may result in low magnesium levels in the body (hypomagnesemia). Symptoms of low magnesium levels include fatigue, muscle spasms or weakness, irregular heartbeat, and seizures. If you develop any of these symptoms, notify your doctor immediately. It is necessary to discuss using Nexlead-d40 capsule with your physician if you are pregnant, suspecting pregnancy, or breastfeeding.

Uses of Nexlead-d40 Capsule

  • Gastroesophageal Reflux Disease (GERD)
  • Peptic Ulcer
  • Treats Nausea and Vomiting

Therapeutic Effects of Nexlead-d40 Capsule

Esomeprazole works by irreversibly binding to the proton pump and inhibiting its function. By doing so, it blocks the final step of acid production. Specifically, this drug inhibits the enzyme's ability to transport hydrogen ions (protons) into the stomach, thereby reducing gastric acid secretion. Domperidone enhances the movement and contractions of the stomach and intestines. It helps to improve gastrointestinal motility and facilitates the food to pass through the digestive part.

Interaction of Nexlead-d40 Capsule with other drugs

Inform your physician about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Nexlead-d40 capsule and reduce effectiveness by causing undesirable side effects. 

More Information about Nexlead-d40 Capsule

  • Store Nexlead-d40 capsule  below (25°C).
  • Keep it out of reach from children.

How to consume Nexlead-d40 Capsule

Take the Nexlead-d40 capsule  as your physician advises. Usually, the capsule will be taken with a glass of water. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the capsule if your doctor advises you to stop.

Safety Advices for Nexlead-d40 Capsule

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If you are pregnant, suspecting, or planning for the pregnancy, report to your doctor before starting the treatment with Nexlead-d40 capsule . 

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Breast Feeding


It is unknown if Nexlead-d40 capsule  passes into the breast milk or if they will harm your baby. Please consult your doctor before breastfeeding. 

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Consult your doctor if you have lung problems before taking Nexlead-d40 capsule .

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Inform your doctor if you have liver disease because Nexlead-d40 capsule  should be used cautiously with a liver condition.

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It is unknown whether consuming alcohol while taking Nexlead-d40 capsule  is safe. Please speak with your physician.

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Traveling, driving vehicles, or operating heavy machinery is safe after taking Nexlead-d40 capsule . This medicine does not impair your ability to drive or use machines.

Side Effects of Nexlead-d40 Capsule

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.


  • Headache
  • Stomach pain, accumulation of gas
  • Nausea, vomiting
  • Constipation
  • Diarrhea
  • Benign polyps in the stomach (masses of cells form in the stomach lining)

Word of Advice

Take the Nexlead-d40 capsule , exactly as your physician prescribes. Do not change the dose or stop taking the medication without consulting your doctor first. This drug is usually taken at least one hour before meals. Follow the general instructions given by your doctor regarding the timing and dosing of the medication. While taking this medicine, making certain dietary modifications to support your treatment may be helpful. Avoid foods and beverages that trigger your symptoms, such as spicy or acidic foods, caffeine, and alcohol. Eat smaller meals and avoid eating close to bedtime. Consider elevating the head of your bed to help reduce nighttime acid reflux.


Q 1. Are there any dietary restrictions or considerations while on Nexlead-d40 capsule?

While there are no specific dietary restrictions associated with Nexlead-d40 capsule, following a healthy diet and lifestyle modifications is generally recommended to support gastrointestinal health.

Q 2. Whether Nexlead-d40 capsule can be taken for heartburn relief?

Yes, Nexlead-d40 capsule can relieve heartburn, especially when associated with gastroesophageal reflux disease (GERD) or peptic ulcer.

Q 3. How does the combination of Nexlead-d40 capsule work?

The medications target both the overproduction of stomach acid and impaired gastrointestinal motility, addressing multiple aspects of the underlying causes of GERD. This combination can provide complete relief and help improve digestive health.

Q 4. What are the common side effects of Nexlead-d40 capsule?

Common side effects of Nexlead-d40 capsule may include nausea, vomiting, infection, rash, itching, painful or tender breasts, and back pain. These side effects are usually temporary and set back to normal as the medication is eliminated.

Q 5. Whether Nexlead-d40 capsule affect kidneys?

Nexlead-d40 capsule is generally considered safe for the kidneys. It is metabolized in the liver and mainly excreted through the bile. The kidneys play a minimal role in eliminating this drug from the body.

Fact Box of Nexlead-d40 Capsule

Molecule name: Esomeprazole+Domperidone

Therapeutic class: Antiulcer+Antiemetic

Pharmacological class: 

1. Esomeprazole-Proton pump inhibitors

2. Domperidone-Dopamine antagonist


  1. Gastroesophageal reflux disease (GERD)
  2. Peptic Ulcer
  3. Treats Nausea and Vomiting


  1. Mylan, Electronic medicines compendium (EMC), [ Revised on Jan 2018] [ Accessed on 07 August 2023],
  2. Ciplamed; [ Accessed on 07 August 2023],
  3. KD Tripathi, Essentials of Medical Pharmacology, Drugs for Peptic ulcer and Gastrointestinal oesophageal reflux disease, 7th edition, 2013, 653.
  4. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Pharmacotherapy of Acidity, ulcers, and Reflux disease, 12th edition, 2011, 1318.


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