ONCO BCG 40MG INJECTION

Introduction:

Onco BCG 40mg Injection is used to treat and reduce the recurrence of bladder cancer. It is used to treat flat urothelial cell carcinoma in urinary bladder and as supplement therapy following transurethral resection (surgical procedure to remove cancerous tissue from the bladder) of superficial noninvasive papillary tumors in bladder. Carcinoma is a type of cancer (abnormal growth of cells) that begins in the epithelial tissue of skin, or in the tissue which lines internal organs. In superficial noninvasive papillary tumors of the bladder, the cells grow abnormally from the inner surface of the bladder toward the hollow center. Talk to your doctor if you have HIV, tuberculosis, urinary tract infections, fever, or gross hematuria (blood in urine) before taking Onco BCG 40mg Injection.

Uses of Onco BCG 40mg Injection:

• Treatment of flat urothelial cell carcinoma of the urinary bladder
• Adjunctive therapy following transurethral resection of superficial noninvasive papillary tumors that are limited to the bladder mucosa

How Onco BCG 40mg Injection works:

Onco BCG 40mg Injection gets internalized in tumor cells, stimulates reticuloendothelial system, induces inflammatory action and cell filtration. This activates NK cells, lymphocytes, and macrophages, triggering cytokines production like interleukin (IL2, IL12), tumor necrosis factor, and interferon-gamma resulting in cytotoxicity of bladder cancer cells.

Interactions with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More information:

Keep Onco BCG 40mg Injection out of sight and reach of children. Store in the dark between 2° to 8°C.

References:

1. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Immunosuppressants, Tolerogens, and Immunostimulants, 12th edition, 2011, 1022.
2. KD Tripathi, Essentials of Medical Pharmacology, Vaccines and sera, 7th edition, 2013, 922.
3. Ciplamed, [Published on 16/08/2017] [Accessed on 15/06/2021], https://5.imimg.com/data5/BJ/HT/LM/SELLER-4164638/sii-onco-bcg-injection.pdf
4. Dominic H Tang, Sam S Chang; Management of carcinoma in situ of the bladder: best practice and recent developments; Therapeutic Advances in Urology; Published on Dec 2015; Accessed on 15/06/2021; https://www.ncbi.nlm.nih.gov/pubmed/26622320
5. Pettenati C, Ingersoll MA, Mechanisms of BCG immunotherapy and its outlook for bladder cancer; Natural Reviews, Urology; Published on Oct 2018; Accessed on 15/06/2021; https://pubmed.ncbi.nlm.nih.gov/29991725/

How to use Onco BCG Injection:

It will be given to you by a doctor or nurse. 

Safety advice:

Pregnancy:

Onco BCG 40mg Injection is contraindicated in pregnancy. Tell your doctor if you are pregnant or planning to get pregnant before taking Onco BCG 40mg Injection.

Breastfeeding:

Onco BCG 40mg Injection is contraindicated in breastfeeding patients. Inform your doctor if you are breastfeeding before taking Onco BCG 40mg Injection.

Others:

• Inform your doctor if you have urinary tract infections UTI, fever, or other diseases.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Common:

• Frequency and urgency of urination, painful urination
• Inflammation of bladder
• Urinary tract infection
• Fever