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Pegadria 20mg Injection
Salt Composition : Pegylated Liposomal Doxorubicin
Manufacturer : INTAS PHARMACEUTICALS LTD
Origin of Medicine : India
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Introduction to Pegadria 20mg Injection
Pegadria 20mg Injection is an anticancer medication that contains the active constituent doxorubicin encapsulated in a closed lipid sphere (liposome). Cancer is a disease in which cells multiply in an uncontrolled and abnormal manner. This medication treats breast cancer, ovarian cancer, multiple myeloma (cancer of white blood cells called plasma cells), and AIDS-related Kaposi’s sarcoma.
People with HIV infection have the highest risk of Kaposi’s sarcoma (cancer that forms in the lining of the lymph and blood vessels). Pegadria 20mg Injection may be given alone or in combination with other anticancer medicines. This medication is not recommended for adolescents and children.
Use effective birth control during the treatment and at least six months after the last dose. It is important to tell your doctor if you are allergic to peanuts or soya if you are receiving medicines for heart or liver disorders, has diabetes, Kaposi’s sarcoma, or have oral problems before taking Pegadria 20mg Injection.
Uses of Pegadria 20mg Injection
- Breast cancer
- Ovarian cancer
- Multiple myeloma
- AIDS-related Kaposi’s sarcoma
Therapeutic Effects of Pegadria 20mg Injection
Pegadria 20mg injection is a new class of drug formulations delivered in vesicles called liposomes. The mechanism of action of doxorubicin HCl is related to its ability to bind DNA and inhibit nucleic acid synthesis. Studies have demonstrated that the drug penetrates rapidly into the cell, binds to certain proteins in DNA, and thereby inhibits cell division and nucleic acid synthesis.
Interaction of Pegadria 20mg Injection with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutrition or vitamin supplements, and herbal products that you are taking or have taken before the treatment. Certain medications may interact with Pegadria 20mg Injection and can cause undesirable side effects.
More Information about Pegadria 20mg Injection
- Keep Pegadria 20mg Injection out of sight and reach of children.
- Store refrigerated at 2°C - 8°C. Do not freeze.
How to consume Pegadria 20mg Injection
Your dose and frequency of administration will be decided by your physician based on your disease condition and other factors. It will be given to you by a healthcare professional. Do not self-administer.
Safety Advices for Pegadria 20mg Injection
Pegadria 20mg Injection may harm the unborn baby. You need to tell your physician if you are pregnant or planning to get pregnant before taking this medicine.
Stop breastfeeding before starting treatment with Pegadria 20mg Injection. You need to tell your physician if you are breastfeeding before taking this medicine.
It is unknown whether Pegadria 20mg Injection can be given to patients with lung diseases. Please consult your physician if you have any lung problems.
You need to tell your physician if you have any liver disorders before taking Pegadria 20mg Injection.
It is not known whether it is safe to consume alcohol with Pegadria 20mg Injection. Please consult your doctor.
Pegadria 20mg Injection may cause tiredness or sleepiness. Avoid driving if you are unwell. Please consult your doctor for more advice.
Side Effects of Pegadria 20mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
- Fever, tiredness, bruising or bleeding
- Severe diarrhea, sores in mouth, nausea, vomiting
- Lung infections, shortness of breath
- Severe stomach pain
- Severe weakness
- Low blood cell counts
- Hair loss
- Decreased appetite
- Skin rashes
- Pain in the muscles and joints
- Feeling confused, difficulty sleeping
- Headache, dizziness, sleepiness
- Change in taste
- High or low blood pressure
- Excessive sweating
- Pain when passing urine
- Weight loss
- Muscle spasms
- Fast heartbeat
Word of Advice
Avoid prolonged sun exposure and unnecessary heat exposure (such as hot dishwater and long hot baths). Avoid pressure on elbows, knees, and soles of feet (such as leaning on elbows, kneeling, and long walks). Wear loose clothing. Keep this medicine out of sight and reach of children. Store the tablets at room temperature. Avoid keeping the tablet in direct sunlight or excessive moisture. Pegylated liposomal doxorubicin may cause dizziness. If you are affected by this side effect, do not drive, use machinery, or do anything that needs alert until you can do it safely.
Q 1. What is the use of Pegadria 20mg Injection?
This medication is used to treat breast cancer, ovarian cancer, multiple myeloma (cancer of white blood cells called plasma cells) and AIDS-related Kaposi’s sarcoma.
Q 2. Is it safe to use Pegadria 20mg Injection while driving?
No, it is unsafe to use this medication while driving and handling heavy machinery as it causes lack of concentration and alertness.
Q 3. How does Pegadria 20mg Injection work?
It damages the genetic material (DNA) of the cancer cells and stops their growth and multiplication.
Q 4. What are the side effects of Pegadria 20mg Injection?
The common side effects of these medications are nausea, vomiting, rash, weakness, low blood platelets, Fatigue, Fever, Loss of appetite, Anemia, and Constipation.
Q 5. Is it safe to use Pegadria 20mg Injection during pregnancy?
It is unsafe to use this medication in patients planning for pregnancy or during pregnancy and breastfeeding mothers as it causes harmful effects for the baby.
Fact Box of Pegadria 20mg Injection
|Molecule Name: Liposomal Doxorubicin||Therapeutic effects: Antineoplastics|
|Pharmacological class: Anthracyclines|
1. Breast cancer
2. Ovarian cancer
3. Multiple myeloma
4. AIDS-related Kaposi’s sarcoma
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1714.
- KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 867.
- Baxter Holding BV, European medicines agency (ema), [Revised on May 2006] [ Accessed on 4th Dec 2021], https://www.ema.europa.eu/en/documents/product-information/caelyx-pegylated-liposomal-epar-product-information_en.pdf
- Ben Venue Laboratories, Inc, US Food and Drug Administration, [Revised on May 2007] [ Accessed on 4th Dec 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/050718s029lbl.pdf
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