Perjeta 420mg Injection is an anticancer medication containing the active constituent Pertuzumab. It is used to treat a type of breast cancer (HER2-positive breast cancer) in combination with other chemotherapy medications. Cancer is a condition in which cells multiply uncontrolled and abnormally.

Perjeta 420mg Injection is not recommended for adolescents and children under 18 years of age. Before taking this medicine, it is vital to inform your doctor if you have or have ever had heart problems or chemotherapy. Use effective birth control during the treatment and for at least six months after the last dose. 

Inform your doctor if you have kidney disease before starting with this Pertuzumab injection. Patients with kidney disease should cautiously use this medicine. Make sure you inform your physician of all the medicines, including supplements and herbal medicines, you are taking before you start treatment with this medicine. Do not stop taking this medication without talking to your physician first. 

• HER2-positive breast cancer

Perjeta 420mg binds to the human epidermal growth factor receptor 2 (HER2) on cancer cells, potentially destroying or inhibiting cancer cell growth.

Inform your healthcare provider about all your medicines, including prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Perjeta 420mg and reduce effectiveness by causing undesirable side effects.  

• Keep Perjeta 420mg Injection out of sight and reach of children.
• Store in refrigerator at 2°C to 8°C. Do not freeze.

Perjeta 420mg Injection is available as an injection and administered intravenously once every three weeks. Follow your physician's instructions. Your doctor will determine the frequency and dose of administration because it varies for each person depending on the disease condition. Don’t self-administer. 

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. 

Serious

• Severe or persistent diarrhea
• Low white blood cell count
• Infusion reactions (fever, chills, hot flushes, nausea, headache, joint, and muscle pain)
• Severe allergic reactions (swelling of throat and face, difficulty in breathing)
• Heart problems (cough, swelling in arms or legs, shortness of breath)
• Tumour lysis syndrome (confusion, tiredness, irregular heartbeat, seizures, tingling sensation)

Common

• Hair loss
• Rash
• Sore mouth
• Constipation
• Poor appetite
• Changes in taste
• Sleeping troubles
• Nose bleeds
• Heartburn
• Nail problems
• Producing more tears
• Feeling dizzy
• Dry and itchy skin
• Ear, nose, or throat infection

Perjeta 420mg can cause heart problems like heart failure,  irregular heartbeats, and uncontrolled high blood pressure. So inform your doctor about your medical history before starting with the treatment. If you experience any symptoms mentioned above, consult your doctor immediately. While undergoing treatment, use effective contraception and continue it for six months after stopping treatment.

1. Roche Products Ltd, Electronic medicines compendium (emc), [Revised on January 2022] [ Accessed on 15 March 2023], https://www.medicines.org.uk/emc/files/pil.2993.pdf
2. PERJETA,U.S Food & Drug Administration FDA, [Revised on Jun 2012],[Accessed on15 March 2023],https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/125409lbl.pdf
3. Komal Jhaveri, Francisco J Esteva; Pertuzumab in the treatment of HER2+ breast cancer; Journal of the National Comprehensive Cancer Network; Published on April 2014; Accessed on 15 March 2023; https://pubmed.ncbi.nlm.nih.gov/24717573/  
4. Kei Ishii; Pertuzumab in the treatment of HER2-positive breast cancer: An evidence-based review of its safety, efficacy, and place in therapy; [Published online on 31st Oct 2019];[Accessed on 21st Feb 2023];  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827570