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000 IU INJECTION_200139_1
84% Off

Polyfic Plus 5,00,000 IU Injection

Prescription Required

Salt Composition : Polymyxin B


Origin of Medicine : India

MRP: 3527
Price :564
You Save :2963 (84%)

1 Vial(s)

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Introduction to Polyfic Plus 5,00,000 Iu Injection

Polyfic Plus 500000IU injection contains an active component as Polymyxin B. This medication is an antibiotic medication used to treat various bacterial infections, especially those caused by Gram-negative bacteria. It is commonly used when other antibiotics are ineffective or when dealing with multi-drug-resistant bacteria.  It may be prescribed for conditions such as urinary tract infections, pneumonia, bacterial skin infections, and ventilator-associated pneumonia. A urinary tract infection (UTI) is a bacterial infection that affects the urinary system, primarily the bladder, urethra, or kidneys. Pneumonia is a respiratory condition characterized by inflammation of the lungs, usually caused by infection from bacteria, viruses, or fungi. Ventilator-associated pneumonia (VAP) is a type of lung infection that occurs in patients who are on mechanical ventilation in the hospital, typically caused by bacteria entering the lungs through the ventilator tube.

Polyfic Plus 500000IU injection is a strong antibiotic that fights tough bacterial infections, especially those caused by certain harmful bacteria. It is used when other medicines don't work well. However, it needs careful monitoring because it can cause problems with the kidneys and nervous system. Still, it's important in critical care to treat difficult infections. If a person has a known hypersensitivity or history of allergic reactions to Polyfic Plus 500000IU injection or related drugs, they should avoid using this medication. 

This medication can be potentially nephrotoxic, meaning it may cause harm to the kidneys. If a person has impaired kidney function or a history of kidney disease, always consult a health care professional. For children, dosage adjustments may be needed to avoid kidney and neurotoxicity risks. In the elderly, monitoring kidney function is important to prevent adverse effects. 

Uses of Polyfic Plus 5,00,000 Iu Injection

Polyfic Plus 500000IU injection is used in the following:

  • Bacterial infections
  • Alternative for multi-drug resistant bacteria
  • Urinary tract infections (UTIs)
  • Pneumonia
  • Bacterial skin infections
  • Ventilator-associated pneumonia (VAP)
  • Skin infections

Therapeutic Effects of Polyfic Plus 5,00,000 Iu Injection

Polyfic Plus 500000IU injection acts by disrupting the outer membrane of Gram-negative bacteria. It binds to and interacts with the lipopolysaccharide layer, a crucial component of the bacterial cell wall, causing membrane destabilization. This leads to increased permeability, leakage of cell contents, and eventual cell death. By targeting the outer membrane, This medication effectively neutralizes Gram-negative bacteria, making it particularly valuable in treating infections caused by these bacteria, especially in cases of multidrug resistance where other antibiotics may not be effective.

Interaction of Polyfic Plus 5,00,000 Iu Injection with other drugs

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Polyfic Plus 500000IU injection, reducing effectiveness by causing undesirable side effects. 

More Information about Polyfic Plus 5,00,000 Iu Injection

  • Store at room temperature, between 20°C to 25°C (68°F to 77°F).
  • Keep away from moisture, heat, and light.
  • It should not be frozen.
  • Keep away from children and pets.

How to consume Polyfic Plus 5,00,000 Iu Injection

Polyfic Plus 500000IU injection should be taken exactly as prescribed by a healthcare professional. It is available in various forms, such as tablets or capsules. The dosage and frequency depend on the medical condition being treated. This medication can be taken with or without food, and patients should not adjust the dosage or stop taking it without medical guidance. Following the doctor's instructions is very important, and if you experience any possible side effects, make sure to inform your healthcare provider right away.

Safety Advices for Polyfic Plus 5,00,000 Iu Injection

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During pregnancy, it is crucial to consult a healthcare professional before using Polyfic Plus 500000IU injection. The potential benefits and risks to both the mother and the baby should be carefully evaluated, and alternative treatments should be considered if possible. 

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Breast Feeding


Consult a healthcare professional before using Polyfic Plus 500000IU injection. Limited systemic absorption minimizes the risk of it passing into breast milk.

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When using Polyfic Plus 500000IU injection to treat lung infections, adhere to the prescribed treatment plan provided by your healthcare professional. Monitor for any potential side effects and avoid exposure to lung irritants, such as smoke and pollutants, to support respiratory well-being during the treatment.

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When using Polyfic Plus 500000IU injection in individuals with liver conditions, consult a healthcare professional for proper evaluation.

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Combining Polyfic Plus 500000IU injection with alcohol is generally not recommended. Alcohol may have additive effects on the central nervous system when used with this medication, causing increased drowsiness, dizziness, or impaired coordination. It is advisable to avoid alcohol while taking this medication, as it may worsen side effects and interactions.

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Polyfic Plus 500000IU injection may cause drowsiness and dizziness. Avoid driving or operating machinery if you experience these side effects.

Side Effects of Polyfic Plus 5,00,000 Iu Injection

Polyfic Plus 500000IU injection causes some side effects like all medications, although not everyone will experience them. 


  • Allergic reactions
  • Kidney damage
  • Neurotoxicity


  • Injection site reactions (for intravenous administration)
  • Nausea or vomiting
  • Diarrhea
  • Loss of appetite
  • Rash or skin irritation (for topical application)

Word of Advice

When using Polyfic Plus 500000IU injection, it is important to take certain precautions for safe and effective treatment. Inform your healthcare provider about any known allergies, especially to antibiotics like colistin. For individuals with impaired kidney or liver function, dose adjustments and close monitoring may be necessary. Be vigilant for potential adverse effects, such as neurotoxicity, skin irritation, or allergic reactions, and report any new or worsening symptoms promptly. Avoid alcohol consumption while on using this medication to prevent interactions and worsened side effects. Complete the full prescribed course of treatment, even if you start feeling better, to avoid bacterial resistance and superinfections. Follow your healthcare provider's advice on dosage and monitoring. Keep all healthcare providers informed about your medication use to prevent potential drug interactions. Store this medicine correctly and dispose of any unused medication as recommended. Adhering to these precautions will help ensure the safe and successful use of this medication.


Q 1. How long does it take for Polyfic Plus 500000IU injection to work?

The effectiveness of Polyfic Plus 500000IU injection varies depending on the type and severity of the infection. Improvement is typically observed within a few days, but the full course of treatment should be completed as prescribed.

Q 2. What should I do if I miss a dose of Polyfic Plus 500000IU injection?

Contact your healthcare provider if you miss a dose of Polyfic Plus 500000IU injection. Follow their instructions on what to do next.

Q 3. Can I use Polyfic Plus 500000IU injection for a skin infection without a doctor's prescription?

Polyfic Plus 500000IU injection should only be used under the supervision and prescription of a qualified healthcare professional, even for skin infections.

Q 4. Can Polyfic Plus 500000IU injection cause hearing or vision problems?

While hearing and vision problems are rare side effects of Polyfic Plus 500000IU injection, it is essential to notify your healthcare provider if you experience any changes in hearing or vision during treatment.

Q 5. Is it safe to use Polyfic Plus 500000IU injection in older adults with multiple health conditions?

Polyfic Plus 500000IU injection use in older adults with multiple health conditions may require close monitoring and dosage adjustments. Consult a healthcare professional for individualized guidance.

Q 6. What should I do if I experience skin irritation or a rash after using topical Polyfic Plus 500000IU injection?

If you experience skin irritation or a rash after using topical Polyfic Plus 500000IU injection, discontinue its use and inform your healthcare provider promptly.

Fact Box of Polyfic Plus 5,00,000 Iu Injection

Molecule name: Polymyxin B

Therapeutic class: Antibiotics

Pharmacological class: Antibiotics



1. Bacterial infections

2. Alternative for multi-drug resistant bacteria

3. Urinary tract infections (UTIs)

4. Pneumonia

5. Bacterial skin infections

6. Ventilator-associated pneumonia (VAP) 

7. Skin infections


  1. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Protein synthesis inhibitors and miscellaneous antibacterial agents, 12th edition, 2011, 1538 -1539.
  2. KD Tripathi, Essentials of Medical Pharmacology, Macrolide and other antibacterial antibiotics, 7th edition, 2013, 759.
  3. Bedford Laboratories, US Food and Drug Administration, [Revised on June 2011] [ Accessed on 01th August  2023],


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