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Prugonist 2mg Tablet

Prescription Required

Salt Composition : Prucalopride


Origin of Medicine : India

MRP: 230
Price :196
You Save :34 (15%)

10 Tablet(s) In A Strip

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Introduction to Prugonist 2mg Tablet

Prugonist 2mg Tablet is a stimulant purgative medication containing the active ingredient Prucalopride. This medication treats chronic idiopathic constipation (CIC) in adults. Chronic idiopathic constipation is a medical condition caused by infrequent bowel movements and difficulty passing stool, which persists over an extended period without an identifiable underlying cause. This medicine is not recommended for children or adolescents under 18 years old.

This drug is contraindicated in individuals with known hypersensitivity or allergy to it or its component. Individuals undergoing renal dialysis should avoid taking Prugonist 2mg Tablet. Renal dialysis is a treatment for individuals with severe kidney problems, and the medication might not suit them. If you have certain gastrointestinal conditions such as perforation or obstruction of the gut wall, toxic megacolon/megarectum, or severe inflammation of the intestinal tract (e.g., Crohn’s disease, ulcerative colitis), avoid taking this medicine with these conditions because it may worsen symptoms or lead to serious complications.

If you have severe kidney or liver disease, you should take special care and consult your doctor before using Prugonist 2mg Tablet. Individuals under medical supervision for serious medical conditions such as lung or heart disease, nervous system or mental health problems, cancer, AIDS, or hormonal disorders should inform their doctor before using the medication. This drug is not recommended for use during pregnancy and breastfeeding. If you are pregnant, breastfeeding, or planning for the pregnancy, report to your doctor before starting the treatment with this drug.

Uses of Prugonist 2mg Tablet

  • Treatment of chronic idiopathic constipation (CIC)

Therapeutic Effects of Prugonist 2mg Tablet

Prugonist 2mg Tablet works by targeting specific serotonin receptors in the digestive system, which helps to stimulate bowel movements and improve the motility of the intestines. By enhancing intestinal contractions, this drug facilitates the movement of stool through the digestive tract, thereby relieving constipation.

Interaction of Prugonist 2mg Tablet with other drugs

Inform your physician about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Prugonist 2mg Tablet and reduce effectiveness by causing undesirable side effects.

More Information about Prugonist 2mg Tablet

  • Store Prugonist 2mg Tablet at a temperature below 25°C.
  • Protect from light and moisture.

How to consume Prugonist 2mg Tablet

Take the Prugonist 2mg Tablet as advised by your physician. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.

Safety Advices for Prugonist 2mg Tablet

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Prugonist 2mg Tablet is not recommended for use during pregnancy. If you are pregnant, suspecting, or planning for the pregnancy, report to your doctor before starting the treatment with this drug. 

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Breast Feeding


Prugonist 2mg Tablet can pass into breast milk. Therefore, breastfeeding is not recommended while undergoing treatment with this drug.

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Inform your doctor if you have lung issues before initiating the therapy with Prugonist 2mg Tablet.

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Prugonist 2mg Tablet should be cautiously administered in patients with severe liver diseases. Dose adjustments are necessary. Inform your doctor if you have liver issues before initiating the therapy.

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It is unknown whether consuming alcohol interacts with Prugonist 2mg Tablet. Please consult your doctor for more advice.

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Prugonist 2mg Tablet may be less likely to impair your ability to drive or operate machinery. Consult your doctor for more advice.

Side Effects of Prugonist 2mg Tablet

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.


  • Pounding heart
  • Depression and suicidal thoughts


  • Headache
  • Sickness
  • Diarrhea
  • Stomach pain
  • Decreased appetite
  • Vomiting
  • Dizziness
  • Indigestion
  • Abnormal bowel sounds
  • Tiredness
  • Bloating

Word of Advice

Tell your doctor immediately about all the medications you have been taking recently, including herbal and nutritional supplements, before taking Prugonist 2mg Tablet. Drink plenty of water throughout the day. Adequate hydration can help soften stools and support regular bowel movements. Include fiber-rich foods like fruits, vegetables, whole grains, and legumes in your diet. Regular exercise can also aid in maintaining healthy bowel function.


Q 1. Who should take Prugonist 2mg Tablet?

Prugonist 2mg Tablet is intended for adults who are diagnosed with chronic idiopathic constipation, a condition characterized by infrequent bowel movements and difficulty passing stool. It's important to consult a physician before starting this drug to ensure it's appropriate for your specific condition.

Q 2. How is Prugonist 2mg Tablet taken?

Prugonist 2mg Tablet is taken orally in tablet form. Your physician will determine the recommended dosage and frequency. It's often taken once a day, usually in the morning.

Q 3. Is Prugonist 2mg Tablet suitable for all types of constipation?

Prugonist 2mg Tablet is specifically indicated for chronic idiopathic constipation. It may not be suitable for constipation caused by other underlying medical conditions.

Q 4. How does Prugonist 2mg Tablet work?

Prugonist 2mg Tablet is a selective serotonin-4 (5-HT4) receptor agonist. It targets serotonin receptors in the digestive system, which enhances intestinal contractions, promoting bowel movements and reducing constipation.

Q 5. What are the common side effects of Prugonist 2mg Tablet?

The common side effects of Prugonist 2mg Tablet may include headache, nausea, diarrhea, abdominal discomfort, and an increased risk of heart palpitations. If these side effects are severe. Contact your doctor immediately.

Fact Box of Prugonist 2mg Tablet

Molecule name: Prucalopride

Therapeutic class: Stimulant purgative

Pharmacological class:  5-HT4 receptor agonist

Indications: Treatment of chronic idiopathic constipation(CIC)


  1. Dexcel®-Pharma Ltd., Electronic Medicines Compendium (EMC), [Revised on March 2023] [Accessed on 25th August 2023],
  2. Shire US Inc., US Food & Drug Administration, [Revised on Dec 2018] [Accessed on 25th August 2023],
  3. I.D. Penman, C.W. Lees, Alimentary tract and pancreatic disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 837-920.
  4. KD Tripathi, Drugs for Constipation and Diarrhoea, Essentials of Medical Pharmacology, 8th Edition, 2019, 721-738.


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