Revolade 25mg tablet is an anticoagulant drug belonging to the thrombopoietin (TPO) receptor agonist category, containing the active ingredient Eltrombopag. It treats low platelet counts caused by primary immune thrombocytopenia (ITP) or hepatitis C (HCV) infection. ITP refers to an autoimmune disorder in which the immune system destroys platelets. 

Platelets are blood cells that aid in clotting and protect blood vessel walls. When platelet levels are low, it can result in severe bleeding and bruising. This tablet is also used in adults to treat low blood counts caused by severe aplastic anaemia (a serious blood disease that occurs when the bone marrow fails to produce enough new blood cells).

This drug should not be used in individuals with known hypersensitivity or allergic reactions to the drug or its components. Allergic reactions can range from mild to severe and may include symptoms such as rash, itching, swelling, dizziness, or difficulty breathing. Revolade 25mg tablets are contraindicated in patients with severe liver impairment or active liver disease. This drug can potentially cause hepatotoxicity, as increased liver enzymes and bilirubin levels indicate. 

Using this drug in individuals with severe liver disease can further worsen liver function, so caution is advised. Your doctor will recommend that you are checked for cataracts. Your doctor should arrange regular testing if you do not have routine eye tests. You may also be checked for bleeding in or around your retina (the light-sensitive layer of cells at the back of the eye).

If you stop taking this tablet, your blood platelet count is likely to become low again within several days. The platelet count will be monitored, and your doctor will discuss appropriate precautions. A very high blood platelet count may increase the risk of blood clotting. However, blood clots can also form with normal or even low platelet counts. Your doctor will adjust your dose of this medicine to ensure that your platelet count does not become too high. 

Do not take this tablet with dairy products or drinks, as the calcium in these items affects the absorption of the medicine. Use effective birth control during the treatment, and if you become pregnant, you must inform your doctor. Revolade 25mg tablets are not advised for children under one with ITP. 

It is also not recommended for patients under 18 with low platelet counts caused by hepatitis C or severe aplastic anaemia. Tell your doctor if you are taking, have recently taken, or might take other medicines. It includes medicines obtained without a prescription and vitamins.

The revolade 25 mg tablet uses include:

• Low platelet counts are caused by primary immune thrombocytopenia (ITP) or hepatitis C virus (HCV) infection.
• Severe aplastic anemi

Revolade 25mg tablets stimulate megakaryocytes (the large bone marrow cells) responsible for producing platelets. By raising the number of platelets in the blood, this drug prevents bleeding and bruising.

Inform your healthcare provider about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications include antacid medicines, statins, ciclosporin, methotrexate, topotecan, lopinavir, or ritonavir, and vitamin and mineral supplements may interact with Revolade 25mg Tablet and reduce effectiveness by causing undesirable side effects. 

• Store Revolade 25mg Tablet at room temperature (25°C).
• Keep the medicine out of reach of children and pets.

It is an orally available prescription drug. Your doctor will decide the dose and duration of the drug based on the disease condition and other factors. Always take a tab revolade 25mg as prescribed by your doctor. Take the tablet with or without food. Do not chew, crush, or break the tablet. Swallow the whole tablet with water.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. The revolade 25 mg side effects are:

Common effects of Revolade 25mg Tablet are:

• Nausea
• Diarrhea, abdominal pain
• Common cold
• Cough
• Respiratory tract infection
• Back pain
• High temperature, cough
• Loss of appetite
• Hair loss
• Swelling in feet or hands
• Headache, dizziness
• Mouth and throat pain
• Joint pain

Ensure that in the 2 hours after or 4 hours before you take this medication, you don’t consume dairy foods (such as cheese or butter), milk or milkshakes, antacids, and supplements containing iron, aluminum, magnesium, calcium, selenium, zinc, or calcium. If you forget to take the Revolade 25mg tablet, take your next dose at the usual time. Do not take more than one dose of this drug daily. Don’t stop taking this tablet without talking to your doctor. If your doctor advises you to stop treatment, your platelet count will be checked each week for four weeks. If you have any doubts regarding the use of this medicine, ask your doctor.

1. Novartis Pharmaceuticals UK Limited, Electronic medicines compendium (EMC), [ Revised on Jan 2022] [Accessed on 22 May 2023], https://www.medicines.org.uk/emc/files/pil.508.pdf
2. GlaxoSmithKline, US Food and Drug Administration, [ Revised on October 2008] [Accessed on 22 May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/022291lbl.pdf
3. Revolade, Annex I summary of Product Characteristics - European Medicines Agency. Available at: https://www.ema.europa.eu/en/documents/product-information/revolade-epar-product-information_en.pdf [Accessed on 22 May 2023].