• Reduces total cholesterol, LDL cholesterol, and triglyceride levels in the blood.

This medicine reduces your cholesterol in two ways: it reduces the cholesterol absorbed in your digestive tract and the cholesterol your body makes by itself. Rosuvastatin is an HMG CoA-reductase inhibitor; it increases the number of hepatic LDL receptors on the cell surface to enhance the uptake and breakdown of LDL and inhibits hepatic synthesis of VLDL (very low-density lipoprotein), thereby reducing the total number of cholesterol levels. 

Ezetimibe inhibits cholesterol absorption in the small intestine; it localizes at the brush border of the small intestine and decreases the delivery of intestinal cholesterol to the liver; this reduces hepatic cholesterol stores and increases cholesterol clearance from the blood.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications interact with Rosuvas EZ 10mg tablet and reduce their effectiveness by causing undesirable side effects. Do not take cyclosporin while taking this medicine.  

• Store the Rosuvas EZ 10mg tablet at 20°C to 25°C
• Protect the medicine from light and excessive moisture.
• Keep the medicine out of reach of children and pets
• If you forgot to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.

Your doctor will decide the dose and duration of Rosuvas EZ 10mg tablet based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. Take the tablet at the same time every day, with or without food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water. 

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. 

 Common 

• Abdominal pain
• Constipation, diarrhea
• Nausea
• Increased liver enzymes
• Muscle, bone, and joint pain
• Headache
• Fatigue
• Cold and fever 

Serious  

• Increased blood sugar levels
• Increased liver enzymes and liver injury
• Muscle problems
• Kidney problems
• Sleep disturbances

You should follow a low-cholesterol diet and exercise while taking this medicine. If you need to take an antacid, take it at least 2 hours after using this medicine. Inform your doctor if you have thyroid problems before initiating the treatment. This medicine may affect the liver; for this reason,  your doctor will regularly carry out liver function test during the treatment. You are likely to be at risk of developing diabetes if you have high levels of sugars and fats in your blood, are overweight, and have high blood pressure.

1. Package leaflet: Information for the user rosuvastatin/Ezetimibe Abbott. Available at: https://file.wuxuwang.com/hma/NL_H_4917_001_FinalPL.pdf  (Revised: March 2023) (Accessed: 29 May 2023).
2. “Highlights Of Prescribing Information - Rosuvastatin + Ezetimibe.” (Revised March 2021) https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/213072s000lbl.pdf
3. Barrios, Vivencio, and Carlos Escobar. “Fixed-Dose Combination of Rosuvastatin and Ezetimibe: Treating Hypercholesteremia according to Cardiovascular Risk.” Expert Review of Clinical Pharmacology, vol. 14, no. 7, 24 May 2021, pp. 793–806, pubmed.ncbi.nlm.nih.gov/33970743/#:~:text=Rosuvastatin%20is%20a%20high%2Dintensity,to%20reduce%20LDL%2DC%20levels., https://doi.org/10.1080/17512433.2021.1925539 . (Accessed 2 Dec. 2021.)