SALAZAR TABLET
SULFASALAZINE
Manufacturer : ZYDUS CADILAOrigin of Medicine : IndiaIntroduction:
Salazar 500mg Tablet contains sulfasalazine. It is used to treat inflammatory bowel disorders, ulcerative colitis, and Crohn’s disease. In ulcerative colitis, the lining of the large bowel (colon and back passage) becomes inflamed, resulting in rectal bleeding, abdominal pain, and frequent diarrhea. In Crohn’s disease, any part of the digestive system from the mouth to anus can get affected (most commonly the last part of the small bowel and first part of the large bowel), resulting in bloody diarrhea and abdominal pain.
Salazar 500mg Tablet is also used to treat rheumatoid arthritis (form of arthritis that causes stiffness, swelling, and loss of function in joints) and ankylosing spondylitis (a rare form of arthritis causing stiffness and pain in your spine). This medicine should not be used if you have porphyria (rare blood pigment disorder), or if you are allergic to aspirin or certain antibiotics (sulfonamides). This medicine is not recommended for children under 2 years of age.
Talk to your doctor if you have liver problems, kidney problems, asthma, blood disorders, or if you have an inherited condition in which your body lacks an enzyme known as glucose-6-dehydrogenase before taking Salazar 500mg Tablet. To avoid kidney problems, you should drink adequate fluids while taking this medicine.
Uses of Salazar 500mg Tablet:
- Ulcerative colitis
- Chron’s disease
- Rheumatoid arthritis
- Ankylosing spondylitis
How Salazar 500mg Tablet works:
It blocks the production and action of certain substances (cyclooxygenase, prostaglandins, etc.) and the growth of certain bacteria which are involved in producing inflammation, thereby reduces inflammation, diarrhea, and bleeding.
Interactions with other drugs:
Inform your doctor about any medications you are taking or have taken before the treatment.
More information:
- Keep Salazar 500mg Tablet out of sight and reach of children.
- Store below 25ºC.
References:
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Anti-inflammatory, antipyretic, and analgesic agents; pharmacotherapy of gout, 12th edition, 2011, 993.
- KD Tripathi, Essentials of Medical Pharmacology, Antirheumatoid and antigout drugs, 7th edition, 2013, 212.
- Pfizer, Electronic medicines compendium (emc), [Revised on Oct 2019] [ Accessed on 17th July 2021], https://www.medicines.org.uk/emc/files/pil.3838.pdf
- Pfizer Healthcare Ireland, The Health Products Regulatory Authority (hpra), [Revised on Sept 2018] [ Accessed on 17th July 2021], https://www.hpra.ie/img/uploaded/swedocuments/d3fcb110-b8d2-45fc-bfd2-d9d4dfeeca41.pdf
- Sharma SK et al; A randomized controlled trial to study the efficacy of sulfasalazine for axial disease in ankylosing spondylitis; International Journal of Rheumatic Diseases, Published on 24/07/2017; Accessed on 17/07/2021; https://pubmed.ncbi.nlm.nih.gov/28737251/
- Pfizer, US Food and Drug Administration, [Revised on 2009] [ Accessed on 17th July 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/007073s124lbl.pdf
How to use Salazar 500mg Tablet:
Take Salazar 500mg Tablet in a dose and duration prescribed by your doctor. The tablets should be swallowed whole. Do not crush or chew the tablets. To avoid kidney problems, you should drink adequate fluids while taking this medicine.
Safety advice:
Pregnancy:
Tell your doctor if you are pregnant or planning to get pregnant before taking Salazar 500mg Tablet. It will be given to you if clearly needed.
Breastfeeding:
You should not breastfeed while taking Salazar 500mg Tablet. Inform your doctor if you are breastfeeding before taking this medicine.
Liver:
You need to tell your doctor if you have any liver disorders before taking Salazar 500mg Tablet. Your doctor will monitor your liver condition before starting the treatment.
Kidney:
You need to tell your doctor if you have any kidney disorders before taking Salazar 500mg Tablet. Your doctor will monitor your kidney condition before starting the treatment.
Others:
- Inform your physician if you are allergic to any medicines or have porphyria before taking Salazar 500mg Tablet.
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious:
- Severe allergic reactions
- Unexplained bleeding, bruising
Common:
- Heartburn, indigestion
- Nausea
- Headache, dizziness
- Difficulty sleeping
- Change in taste
- Diarrhea
- Ringing in the ears
- Inflamed mouth
- Cough, fever
- Protein in urine
- Joint pain

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