• Short-term management of acute decompensated heart failure (ADHF)

Simenda12.5mg injection exhibits its inotropic and vasodilatory action by sensitizing calcium channels, resulting in increased cardiac output without increasing the oxygen demand of the heart. It also lessens the congestion in your lungs, making it easier for blood and oxygen to go through your body, thereby relieving the shortness of breath due to severe heart failure.

Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with simenda12.5mg injection and cause undesirable side effects. Tell your doctor if you have been given other heart medicines through your veins.

• Store in refrigerator at (2°C-8°C)
• Do not freeze
• Do not dispose of the medication in wastewater or household waste. Always return to the pharmacy when you no longer require the medication.

Simendal 12.5mg is given only in a hospital setup by a healthcare provider. It is infused directly into your veins by your physician. Your physician will decide the dosage and frequency of this injection based on the severity of your disease and other factors. 

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. 

Common

• Headache
• Abnormally fast heartbeat
• Drop in blood pressure
• A low amount of potassium in your blood
• Insomnia
• Dizziness
• Abnormally fast heartbeats (atrial fibrillation)
• Oxygen insufficiency
• Nausea
• Constipation
• Diarrhea
• Vomiting
• Low blood counts (anemia)

Simenda12.5mg injection is strictly meant for in-hospital use and should be administered by your healthcare provider. Throughout your simenda12.5mg injection treatment, your doctor will closely monitor your heart rate, blood pressure, and electrocardiogram (ECG) to measure your response. After you have finished the medication, your doctor will continue monitoring you for about 4-5 days and may adjust your dose when necessary. It is crucial to stick to your regular follow-up appointments to minimize the risk of side effects.

For elderly patients, there are no dose adjustments done, but they require close monitoring. Simenda12.5mg injection can cause a drop in potassium levels, so your doctor might prescribe potassium supplements to prevent this. Also, consider incorporating iron-rich foods into your diet, as this medication can lead to anemia. Remember to schedule a complete cholesterol screening (lipid profile test) at least once a year to keep track of your heart health. Additionally, keep an eye on your blood pressure, heart rate, and electrolyte levels. Always consult your doctor if you have any concerns before starting this medication. If you experience any side effects during or after treatment, be sure to inform your healthcare provider promptly.

1. As Kalceks, Health Products Regulatory Authority (HPRA), [Revised on Feb 2022], [Accessed on 21st Sept 2023], https://www.hpra.ie/img/uploaded/swedocuments/f255c6f4-40a8-4c0f-b034-e20069403900.pdf
2. Orion Pharma, Sweden Medical Products Agency (MPA), [Revised on Jun 2010], [Accessed on 21st Sep 2023], https://www.simdax.com/siteassets/simdax-spc.pdf
3. KD Tripathi, Essentials of Medical Pharmacology, Cardiovascular drugs, 8th edition, 2019, 568
4. Bertram G. Katzung, Drugs Used in Heart Failure, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 212-227.