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  ÂSivel 400mg Tablet
Prescription Required
Salt Composition : Sevelamer
Manufacturer : SANZYME PVT LTD
Origin of Medicine : India
10 Tablet(s) In A Strip
Introduction to Sivel 400mg Tablet
Sivel 400mg tablet contains an active ingredient called Sevelamer. It belongs to the medication class known as phosphate binders. It is used to manage hyperphosphatemia (high blood phosphate levels) in adult patients undergoing dialysis (hemodialysis or peritoneal dialysis) and patients with chronic kidney disease who have elevated serum phosphorus levels. It should be used with other treatments, such as calcium supplements and vitamin D, to prevent bone disease. High blood phosphorus levels can cause calcification, where hard deposits form and stiffen blood vessels, affecting blood flow. Â
Do not consume Sivel 400mg tablet if you are allergic to Sevelamer or any of its ingredients in the medication. Avoid consuming this medicine if you have low levels of phosphate and bowel obstruction. Before taking this medicine, notify your doctor if you are pregnant, planning to get pregnant, or think you may be pregnant or are breastfeeding. Before starting treatment, let your doctor know if you have trouble swallowing or if your stomach and bowel have problems moving food.Â
Also, inform your doctor if you currently have bowel inflammation or have had major stomach or bowel surgery. Sivel 400mg tablet is not recommended for children under six years old due to the lack of studies on its safety and effectiveness in that age group. If your doctor has advised you about a sugar intolerance, please consult your doctor before taking this medication, as it contains lactose.
Uses of Sivel 400mg Tablet
- Manage hyperphosphatemia (high blood phosphate levels)
- Prevent bone disease in combination with calcium and vitamin D supplements.
Therapeutic Effects of Sivel 400mg Tablet
Sivel 400mg tablet functions by binding phosphate from ingested food within the digestive tract, thereby reducing phosphorus levels in the bloodstream.
Interaction of Sivel 400mg Tablet with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Sivel 400mg tablet and can cause undesirable side effects.Â
More Information about Sivel 400mg Tablet
- Keep out of sight and reach of pets and children.
- Do not freeze the medicine.
- Do not store above 30°C.
- Always check the expiry date before consuming it.
How to consume Sivel 400mg Tablet
Take the Sivel 400mg tablet as your physician advises. Take medicine at a fixed time. It is given based on the level of phosphate in the blood. Usually, it is given three times a day with food. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Do not stop the medicine unless your doctor advises.
Safety Advices for Sivel 400mg Tablet
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Pregnancy
 ÂIt is unknown whether Sivel 400mg tablet is harmful to the unborn baby. Notify your healthcare professional if you are pregnant, planning to get pregnant or think you may be pregnant. The potential benefits and risks of the medicine should be carefully assessed.
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Breast Feeding
 ÂIt is unknown whether Sivel 400mg tablet is excreted in breast milk. So, before starting the treatment, inform your doctor if you are breastfeeding. Consult your doctor for more information
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Lungs
 ÂIt is unknown whether Sivel 400mg tablet is safe for patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
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Liver
 ÂIt is unknown whether Sivel 400mg tablet is safe for patients with liver problems. Inform your physician if you have any liver disease before starting the treatment. Contact your doctor if you experience any liver-related symptoms.
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Alcohol
 ÂIt is unknown whether consuming alcohol while taking Sivel 400mg tablet is safe. Please speak with your physician.
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Driving
 ÂSivel 400mg tablet carbonate is not expected to impair your ability to drive or operate machinery. However, if you experience side effects like tiredness or drowsiness, avoid driving and using machines.Â
Side Effects of Sivel 400mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious
- Intestine or bowel obstruction
Common
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
- Flatulence
- Indigestion
- Constipation
Word of Advice
Before starting the treatment, inform your doctor about all the underlying medical conditions. Do not stop the medicine until your doctor advises. Do not double-dose the medicine to make up for a forgotten dose. Notify your doctor if you experience any serious side effects. Contact your doctor for more information.Â
FAQs
Q 1. How to manage the side effects of Sivel 400mg tablet?
To manage the side effects of Sivel 400mg tablet, follow the prescribed dosage, and report side effects promptly. Stay hydrated, avoid fatty foods and dairy products. Consult your doctor before taking Sivel 400mg tablet with other medications to optimize its effectiveness and reduce side effects. Maintain a healthy lifestyle by following a balanced diet and attending follow-up appointments.
Q 2. What additional supplements might be prescribed by my doctor while taking Sivel 400mg tablet?
Supplements such as calcium, vitamin D, and possibly vitamins A, E, K, and folic acid supplements may be prescribed by your doctor in combination with Sivel 400mg tablet.
Q 3. What are the side effects of Sivel 400mg tablet?
Common side effects of Sivel 400mg tablet include nausea, vomiting, abdominal pain, diarrhea, flatulence, indigestion, and constipation. It is crucial to consult your doctor for any concerns or persistent side effects.
Q 4. Can Sivel 400mg tablet be taken during pregnancy or while breastfeeding?
Information regarding the usage of Sivel 400mg tablet during pregnancy and breastfeeding is unknown. So, it is recommended to get healthcare professionals' advice before consuming the medicine. The potential benefits and risks of the medicine should be carefully assessed.
Q 5. Why should Sivel 400mg tablet be taken with food?
Sivel 400mg tablet is more effective at binding to phosphorus when it is taken with food. Taking this medicine without food can increase your risk of side effects.
Fact Box of Sivel 400mg Tablet
Molecule Name: Sevelamer | Therapeutic class: PO4 scavengers |
Pharmacological class: Phosphate binders. | Indications: 1. Manage hyperphosphatemia (high blood phosphate levels) 2. Prevent bone disease in combination with calcium and vitamin D supplements. |
References
- Zentiva Pharma UK Limited; Electronic Medicines Compendium (EMC); [Revised on Aug 2019] [Accessed on 19th July 2023], https://www.medicines.org.uk/emc/files/pil.8679.pdf
- Genzyme Ireland Ltd; US Food and Drug Administration; [Revised on April 2019] [Accessed on 19th July 2023], label (fda.gov)
- J. Goddard, A.N. Turner, Kidney and urinary tract disease, Davidson's Principles & Practice of Medicine, 22nd Edition, 2014, 461-523.
- Daniel D. Bikle, Agents That Affect Bone Mineral Homeostasis, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 772-791.
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