Did you find this information helpful?
Spamp-E 50 Amphotericin B
Salt Composition : Amphotericin B
Manufacturer : SPAL Private Limited
Origin of Medicine : India
Introduction to Spamp-e 50 Amphotericin B
Spamp-E-50 Amphotericin B is an antifungal medication containing the active ingredient Amphotericin B. It treats fungal infections of one or more deep body organs. It is also used to treat suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells). It is also indicated to treat visceral leishmaniasis, a disease caused by a parasite in certain people.
Do not receive this injection if you are allergic to Spamp-E-50 Amphotericin B or any of the other ingredients in the medicine. Inform your physician if you have a severe allergic reaction, kidney or liver problems, and if you are having dialysis. Tell your doctor if you have low potassium levels. This injection may cause severe infusion reactions such as flushing, itching, sickness, swelling of the face, mouth, tongue, and airways, and difficulty breathing. Inform your physician immediately if you face any of these symptoms.
Before initiating your first treatment, your physician may give you a small amount of Spamp-E-50 Amphotericin B to check for allergic reactions. This medicine contains sugar in each vial. Tell your doctor if you have diabetes. Inform your physician if you are pregnant or breastfeeding before initiating the treatment. Your doctor will decide the dose and quantity of this drug based on your disease condition.
Uses of Spamp-e 50 Amphotericin B
- Treatment of fungal infections
Therapeutic Effects of Spamp-e 50 Amphotericin B
Spamp-E-50 Amphotericin B binds primarily to ergosterol in sensitive fungi cell membranes, causing membrane permeability changes that result in leakage of intracellular contents and cell death.
Interaction of Spamp-e 50 Amphotericin B with other drugs
Inform your physician about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Spamp-E-50 Amphotericin B and reduce effectiveness by causing undesirable side effects.
More Information about Spamp-e 50 Amphotericin B
- Store Spamp-E-50 Amphotericin B between (2°C to 8°C).
- Protect from light and moisture.
How to consume Spamp-e 50 Amphotericin B
A doctor or nurse in a hospital or clinic setting will give it to you. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors
Safety Advices for Spamp-e 50 Amphotericin B
If you are pregnant, suspecting, or planning for the pregnancy, consult your physician for more advice before taking Spamp-E-50 Amphotericin B. Physicians may prescribe this medicine only when it is needed.
If you are a breastfeeding mother, it's important to consult with your doctor before taking Spamp-E-50 Amphotericin B.
It is unknown whether Spamp-E-50 Amphotericin B is safe for patients with lung problems. Inform your physician if you have lung disease before starting the treatment.
It is unknown whether Spamp-E-50 Amphotericin B is safe for patients with liver problems. Inform your physician if you have liver disease before starting the treatment.
It is unknown whether consuming alcohol while taking Spamp-E-50 Amphotericin B is safe. Please speak with your physician.
Some side effects of Spamp-E-50 Amphotericin B may impair your ability to drive or operate machinery safely. It is unsafe to consume this drug.
Side Effects of Spamp-e 50 Amphotericin B
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
- Serious allergic reactions (sudden onset of itching, rash or hives on the skin, shortness of breath and wheezing)
- Increased blood sugar levels
- Decreased potassium levels
- Shortness of breath,
- Fever, chills, or shivering
- Abdominal Pain
Word of Advice
Spamp-E-50 Amphotericin B may cause damage to the kidney. Inform your doctor if you have kidney problems. It may be necessary to continue this medication for several weeks to several months to treat certain infections. Stopping the medication too early may result in a return of the infection. Tell your doctor if your condition lasts or gets worse.
Q 1. What are the possible side effects of Spamp-E-50 Amphotericin B?
While Spamp-E-50 Amphotericin B is generally well-tolerated, it can still have side effects. Common side effects may include fever, chills, headache, nausea, vomiting, increased blood sugar levels, muscle or joint pain, and infusion-related reactions. In rare cases, it may cause more serious side effects such as cardiac arrest, kidney damage or allergic reactions.
Q 2. Can Spamp-E-50 Amphotericin B be used in pediatric patients?
Spamp-E-50 Amphotericin B can be used in babies more than 1 years old, but the dosage and administration may vary depending on the child's age, weight, and specific medical condition. It is crucial to follow the healthcare provider's instructions and closely monitor the child's response to treatment.
Q 3. Why is Spamp-E-50 Amphotericin B less toxic?
Spamp-E-50 Amphotericin B is less toxic because it is less nephrotoxic. Low toxicity of this medicine may be due to the small number of binding receptors in the drug.
Q 4. What are the advantages of using Spamp-E-50 Amphotericin B over other antifungal medications?
One of the key advantages of Spamp-E-50 Amphotericin B is its lower toxicity compared to conventional drugs. This makes it a preferred choice, especially for patients more susceptible to antifungal medications' side effects. Additionally, this drug has a prolonged circulation time in the body, allowing for less frequent dosing.
Q 5. Can I discontinue taking Spamp-E-50 Amphotericin B once I feel better?
Even if you feel better, do not discontinue taking Spamp-E-50 Amphotericin B without consulting your doctor. Before the illness is treated, your symptoms may improve. As a result, it is recommended that you continue your treatment for the suggested term for better and more complete treatment.
Fact Box of Spamp-e 50 Amphotericin B
Molecule name: Amphotericin B
Therapeutic class: Antifungal agents
Pharmacological class: Polyene antifungals
Indications: Treatment of fungal infections
- Gilead Sciences International Ltd, Electronic medicines compendium (EMC), [ Revised on Sept 2020] [ Accessed on 11th June 2023], https://www.medicines.org.uk/emc/files/pil.1022.pdf
- Gilead Sciences, Inc, US Food and Drug Administration, [ Revised on Oct 2008] [ Accessed on 11th June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050740s016lbl.pdf
- Lifecare innovations; [Accessed on June 12th 2023]; https://www.lifecareinnovations.com/mucormycosis.php
- Falah Hasan et al; Topical Amphomul 50mg Injection formulas: Promising new application; [Published on August 2019]; [Accessed on June 11th 2023]; https://www.researchgate.net/publication/334882993_Topical_Amphotericin_B_formulas_Promising_new_application
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Chemotherapy of protozoal infections, 12th edition, 2011, 1424.
- KD Tripathi, Essentials of Medical Pharmacology, Antifungal drugs, 7th edition, 2013, 787-788.
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
We maintain strict quality controls on all our partner retailers, so that you always get standard quality products.
100% secure and trusted payment protection
We have a new and dynamic return window policy for medicines and healthcare items. Refer FAQs section for more details.