SPEXIB 150MG CAPSULE
CERITINIB
Manufacturer : NOVARTIS INDIA LTDOrigin of Medicine : SwitzerlandIntroduction:
Spexib 150mg Capsule consists of the active substance Ceritinib. It is an Anti-Cancer medicine that is the preferred for treating adults with a type of lung cancer called ALK-positive advanced Non-Small Cell Lung Cancer that has started spreading to other organs. ALK-positive refers to the cancer cells that have a fault in the gene responsible for producing the ALK enzyme.
The most common side effects of Spexib 150mg Capsule administration are nausea, vomiting, and diarrhea. Spexib 150mg Capsule tends to increase the value of liver enzymes and could lead to liver toxicity. Hence ensure that your physician monitors your liver functions at regular intervals during this therapy.
Uses of Spexib 150mg Capsule:
- To treat adults with ALK-positive advanced Non-Small Cell Lung Cancer (NSCLC)
- Alternative therapy for patients who have failed to respond to Crizotinib.
How Spexib 150mg Capsule works:
If a person has faults in the ALK gene, their body produces an abnormal protein that enables the growth of cancer cells. Spexib 150mg Capsule works by inhibiting the action of this abnormal protein and stops the growth and multiplication of lung cancer cells.
Interaction with other drugs:
Inform your doctor about any medications you are taking or have taken before the treatment.
More Information:
Do not store above 30°C. Keep the capsules out from the sight and reach of children.
References:
- Bing Xia, Roy S. Herbst, Management of Advanced Non–Small Cell Lung Cancer: Noncurative Intent Treatment, Lung Cancer: A Practical Approach to Evidence-Based Clinical Evaluation and Management, 2018, 99-115.
- Novartis Pharmaceuticals, Electronic Medicines Compendium(EMC), [Revised on Jan 2020] [Accessed on 27th Mar 2021] https://www.medicines.org.uk/emc/files/pil.7109.pdf
- Novartis Pharmaceuticals, Central Drugs Standard Control Organisation, [Revised on 22nd Jan 2019] [Accessed on 27th Mar 2021], https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadPrescribingInfo/9Ceritinib.pdf
How to use Spexib 150mg Capsule:
Take Spexib 150mg Capsule on an empty stomach or along with food. Consume the tablets orally by swallowing them whole with water at the same time every day. Do not crush or chew the capsules. If vomiting occurs, continue taking the capsule as per the schedule instead of taking an extra dose.
Safety Advice:
Pregnancy:
Spexib 150mg Capsule is not recommended in case of pregnancy. Your physician will prescribe Spexib 150mg Capsule only if it is essential.
Breastfeeding:
The risk profile of using Spexib 150mg Capsule during breastfeeding is not established. Consult the physician before breastfeeding.
Liver:
Spexib 150mg Capsule is safe to use by patients having mild to moderate liver impairment. But patients with severe liver dysfunction should consult their physician for dose adjustment.
Kidney:
Patients with severe kidney impairment must use caution. Consult your physician for advice.
Driving:
Spexib 150mg Capsule has the potential to cause tiredness and vision problems. Exercise caution while driving or using machines.
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious:
- Pericarditis
- Low heart rate
- Kidney impairment
- Vision disorder
Common:
- Decreased appetite
- Anemia
- Diarrhea
- Nausea
- Vomiting
- Stomach ache
- Constipation
- Skin rash

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