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SUTENT 12.5MG CAPSULE_1
SUTENT 12.5MG CAPSULE_2
SUTENT 12.5MG CAPSULE_1
15% Off

Sutent 12.5mg Capsule

Prescription Required

Salt Composition : Sunitinib

Manufacturer : PFIZER LTD

Origin of Medicine : United States of America

MRP: ₹14786.42
Price : ₹12545
You Save : ₹2241 (15%)

7 Capsule(s) In A Strip

PAP Information :    Contact us for latest updates.

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Patient Assistance Programs

Get financial assistance directly from pharma companies and cover your cost of medicines or get free medicines for the eligible patient with patient assistance programs (PAP). We provide proper guidance assistance to patients getting enrolled in the patient assistance program.

Introduction to Sutent 12.5mg Capsule

Sutent 12.5mg Capsule consists of the active ingredient Sunitinib. It is classified as a tyrosine kinase inhibitor, which means that it works by blocking certain enzymes called tyrosine kinases that are involved in the growth and spread of cancer cells. This medication is used to treat gastrointestinal stromal tumors (GIST), rare cancer that can start anywhere in the gastrointestinal tract. This medication is also used to treat advanced kidney cancer, and pancreatic cancer called pancreatic neuroendocrine tumors (PNET). Cancer is a disorder in which abnormal cells grow in an uncontrolled manner.  It is not recommended for people under 18. 

Before taking Sutent 12.5mg Capsule, it is important to discuss with the physician if you have blood conditions, heart problems, liver disorders, kidney problems, skin disorders, diabetes, seizures, or thyroid disorders. Also, inform if you have recently had surgery or are about to have surgery. Tell your doctor if you are hypertensive because this medication sometimes causes hypertension as a side effect. Avoid taking grapefruit in any form during the treatment with Sutent 12.5mg Capsule. Check with your dentist if you have any problems in the mouth, such as mouth pain, swelling, or sores inside the mouth before starting treatment.

Uses of Sutent 12.5mg Capsule

Sutent 12.5mg Capsule is used in the treatment of the following condition: 

  • Renal cell carcinoma (RCC)
  • Gastrointestinal stromal tumors (GIST)
  • Pancreatic neuroendocrine tumors (PNET)
  • Medullary thyroid cancer
  • Certain kidney cancer

Therapeutic Effects of Sutent 12.5mg Capsule

The therapeutic effects of Sutent 12.5mg Capsule include slowing down or stopping the growth and spread of cancer cells in the body, thereby reducing the size and number of tumors. It works by inhibiting the activity of specific proteins known as tyrosine kinases, which are involved in the signaling pathways that control cell growth and division. It can help to prevent cancer cells from growing and spreading by blocking these pathways.

Interaction of Sutent 12.5mg Capsule with other drugs

The therapeutic effects of Sutent 12.5mg Capsule include slowing down or stopping the growth and spread of cancer cells in the body, thereby reducing the size and number of tumors. It works by inhibiting the activity of specific proteins known as tyrosine kinases, which are involved in the signaling pathways that control cell growth and division. It can help to prevent cancer cells from growing and spreading by blocking these pathways.

More Information about Sutent 12.5mg Capsule

  • Sutent 12.5mg Capsule should be stored at room temperature, between 68°F and 77°F (20°C and 25°C).
  • Keep it in the original package.
  • Protected from moisture, light, and heat.
  • Keep it out of reach from children and pets.

How to consume Sutent 12.5mg Capsule

Sutent 12.5mg Capsule is taken orally, in the form of capsules, with a glass of water. The capsules should be swallowed whole and not crushed, chewed, or opened. The recommended dose may vary depending on the type of cancer being treated, the patient's age and weight, and other factors. This medication is usually taken once a day, with or without food, at around the same time each day. If you miss a dose then do not double the dose to compensate for the missed dose.

Safety Advices for Sutent 12.5mg Capsule

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Pregnancy

  

Sutent 12.5mg Capsule is unsafe for a developing fetus and is not recommended during pregnancy as it can cause harm to the developing fetus. 

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Breast Feeding

  

It is unknown whether Sutent 12.5mg Capsule is excreted in human breast milk. Breastfeeding women should discuss the potential risks and benefits of the medication with their healthcare provider before starting treatment.

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Lungs

  

Sutent 12.5mg Capsule can cause interstitial lung disease (ILD), a serious and potentially fatal condition that causes scarring of the lungs. Patients taking this medication should be monitored for symptoms of ILD, such as cough, shortness of breath, and fever, and treatment should be interrupted or discontinued if necessary.

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Liver

  

Sutent 12.5mg Capsule can cause liver toxicity, which can be severe or fatal in some cases. Patients taking this medication should be done their liver function tests regularly, and treatment should be interrupted or discontinued if these tests are abnormal.

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Alcohol

  

It is generally recommended to avoid consuming alcohol during treatment with anticancer medication, as alcohol can potentially interfere with the effectiveness of the medication and increases the liver-related and other potential side effects.

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Driving

  

Patients receiving Sutent 12.5mg Capsule are advised to avoid driving or operating machinery if they experience side effects such as fatigue, dizziness, or blurred vision, impairing a patient's ability to drive or operate machinery safely.

Side Effects of Sutent 12.5mg Capsule

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Side effects related to Sutent 12.5mg Capsule are as follows:

Serious:

  • Heart failure or heart attack
  • Elevated liver function tests.
  • Liver failure
  • Proteinuria
  • Acute kidney injury
  • Interstitial lung disease (inflammation of lung walls)
  • Pulmonary arterial hypertension
  • Gastrointestinal perforation or fistula
  • Haemorrhage (bleeding)
  • Hypothyroidism (low thyroid function)
  • Hypoglycemia (low blood sugar)

Common 

  • Fatigue
  • Nausea and vomiting
  • Diarrhoea
  • Loss of appetite
  • Hand-foot syndrome
  • Skin discoloration or rash
  • High blood pressure
  • Headache
  • Hair loss
  • Changes in taste
  • Dry skin or itching
  • Nosebleeds

Word of Advice

If you have been prescribed Sutent 12.5mg Capsule, it is important to follow your healthcare provider's instructions. During treatment avoid taking grapefruit or grapefruit juice as it can increase the levels of medication in the blood and potentially increase the risk of side effects. Use a reliable method of birth control while taking the medication and for at least four weeks after the last dose. 

This medication can cause serious side effects, so it is important to be vigilant and informed about your treatment. Make sure to report any symptoms or changes in your health, even if they seem minor. With proper precautions and monitoring, it can be an effective treatment for certain types of cancer. 

FAQs

Q 1. Can Sutent 12.5mg Capsule cause changes in skin color?

Yes, Sutent 12.5mg Capsule can cause changes in skin color. One common side effect is called "hand-foot syndrome," which can cause redness, swelling, and pain in the palms of the hands and soles of the feet. In some cases, this syndrome can also cause the skin to darken or become thickened in these areas. Additionally, this medication can cause other skin changes, such as rashes and discoloration.

Q 2. Can Sutent 12.5mg Capsule cause heart problems?

Yes, Sutent 12.5mg Capsule can cause heart problems such as high blood pressure, heart failure, and heart attack. Patients taking this medication should be closely monitored by their healthcare provider for any signs of heart problems and may need to undergo regular heart function tests.

Q 3. Can Sutent 12.5mg Capsule cause kidney problems?

Yes, Sutent 12.5mg Capsule can cause kidney problems such as proteinuria (excess protein in the urine) and renal impairment. Patients taking this medication require regular monitoring of kidney function and need to adjust the dosage or switch to a different medication if these side effects occur or persist.

Q 4. Can I take Sutent 12.5mg Capsule if I have a thyroid problem?

Yes, but your healthcare provider will monitor your thyroid function regularly. Sutent 12.5mg Capsules can affect the thyroid gland, causing hypothyroidism (an underactive thyroid gland) or hyperthyroidism (an overactive thyroid gland). Therefore, your healthcare provider will check thyroid hormone levels in your blood before starting treatment, and periodically during treatment.

Q 5. Can Sutent 12.5mg Capsule affect fertility?

Yes, Sutent 12.5mg Capsules can affect fertility in both men and women. Patients taking this medication should discuss the potential risks and options for preserving fertility with their healthcare provider before starting treatment.

Q 6. How can Sutent 12.5mg Capsule affect my blood?

Sutent 12.5mg Capsules can cause hematologic toxicity, which may include neutropenia (low white blood cell count), thrombocytopenia (low platelet count), and anemia (low red blood cell count). These changes can increase the risk of infection, bleeding, and fatigue, respectively.

Fact Box of Sutent 12.5mg Capsule

Molecule name: Sunitinib

Therapeutic class: Anticancer

Pharmacological class: Tyrosine kinase inhibitor

Indications:  

1. Renal cell carcinoma (RCC)

2. Gastrointestinal stromal tumors (GIST)

3. Pancreatic neuroendocrine tumors (PNET)

4. Medullary thyroid cancer

5. Certain kidney cancer

References

  1. Pfizer, U.S Drug and food safety administration (FDA), [Revised on Dec 2018], [Accessed on 5th April 2023], 
    https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021938s035lbl.pdf
  2. Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1203-1236.
  3. Robert J. Thomson; Majid Moshirfar; Yasmyne Ronquillo, Tyrosine Kinase Inhibitors, [Revised on 21st Jan 2021] [Accessed on 5th April 2023],  
    https://www.ncbi.nlm.nih.gov/books/NBK563322/
  4. Pfizer, Electronic Medicines Compendium (EMC) [Revised on Mar 2021] [Accessed on 5th April 2023],  https://www.medicines.org.uk/emc/files/pil.7966.pdf
  5. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.

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