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Tbis 0.1% Ointment

Prescription Required

Salt Composition : Tacrolimus

Manufacturer : BIOCON LTD

Origin of Medicine : India

MRP: 1191.97
Price :1013
You Save :179 (15%)

1 Tube(s) Of 30gm

Delivery By -

Introduction to Tbis 0.1% Ointment

Tbis 0.1% Ointment contains the active substance Tacrolimus. It is an immunosuppressant that belongs to the class of medications called calcineurin inhibitors. It is used to treat moderate to severe atopic dermatitis (eczema) in adults who cannot use other medications for their condition or whose eczema has not responded to other medications. It suppresses the immune system from producing substances that may develop eczema. 

Do not take this Tbis 0.1% Ointment if you are allergic to tacrolimus or any of the other ingredients of this medicine.  Report your physician if you are allergic to any antibiotic group. Inform your doctor if you have or had a  liver failure, skin problems or skin cancer, or a weakened immune system. Notify your physician immediately if you develop fever, bruising under the skin (which may appear as red dots), unexplained tiredness, confusion, yellowing of the skin or eyes, reduced urine output, vision loss, and seizures after taking this medicine. 

Limit exposure to sunlight and UV light while consuming Tbis 0.1% Ointment by wearing appropriate protective clothing and sunscreen with a high sun protection factor. This is because of the potential risk of malignant skin changes with immunosuppressive therapy. Do not apply this ointment to the infected areas if you have infected lesions. If you notice any change in the appearance of your skin, consult your physician immediately. This medicine is not approved for children younger than 16 years of age.

Uses of Tbis 0.1% Ointment

  • Moderate to severe atopic dermatitis (eczema)

Therapeutic Effects of Tbis 0.1% Ointment

Tbis 0.1% Ointment provides immunosuppression by inhibiting T-lymphocyte activation and proliferation and T-helper-cell-dependent B-cell response. It works by attaching to a protein called FKBP-12 and forms a complex called tacrolimus-FKBP, which inhibits the action of calcineurin phosphatase. This, in turn, inhibits the formation of T cells and suppresses the immune response.

Interaction of Tbis 0.1% Ointment with other drugs

Inform your healthcare provider about all the medicines that you take, including prescription medications, over-the-counter medications, vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of Tbis 0.1% Ointment and reduce its effectiveness by causing undesirable side effects. Avoid grapefruit or grapefruit juice while taking this medicine. 

More Information about Tbis 0.1% Ointment

  • Store Tbis 0.1% Ointment at (25°C)
  • keep the capsule away from the reach of children and pets.
  • If you forget to apply the ointment at the scheduled time, do it as soon as you remember. If it is almost time for the application, skip the missed dose.
  • Do not apply more quantity than advised.

How to consume Tbis 0.1% Ointment

This medicine is only for topical use. Always use Tbis 0.1% Ointment exactly as advised by your doctor. Apply the ointment as a thin layer to the affected areas of your skin. Avoid using the ointment inside your nose, mouth, or eyes. Before using the ointment, be sure your skin is completely dry. Your doctor will say the exact amount and time you should use this ointment. If you accidentally swallowed the ointment, contact your physician immediately and seek medical advice.

Safety Advices for Tbis 0.1% Ointment

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Based on animal studies, Tbis 0.1% Ointment can cause harmful effects on the baby. Inform your physician if you are pregnant, suspecting pregnancy, or planning to get pregnant before initiating the treatment. 

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Breast Feeding


Do not consume Tbis 0.1% Ointment if you are breastfeeding because this medicine is excreted into breast milk and may cause harmful effects on the body.

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It is unknown whether Tbis 0.1% Ointment can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

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Tbis 0.1% Ointment should be cautiously administered in patients with severe liver diseases. Dose adjustments are necessary for severe liver failure. Inform your doctor if you have liver problems before initiating the therapy.

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It is unsafe to consume alcohol when taking Tbis 0.1% Ointment because it may cause the skin or face to become flushed or red and feel hot.

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It is unknown whether Tbis 0.1% Ointment can impair the ability to drive. Consult your doctor for more advise.

Side Effects of Tbis 0.1% Ointment

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.


  • Burning sensation and itching
  • Redness, feeling or warmth
  • Pain
  • Increased skin sensitivity to hot and cold
  • Skin tingling
  • Rash


  • Acne
  • Facial redness
  • Eye infections
  • Lentigo (flat brown spots on the skin)
  • Cold sores
  • Swelling of the hands, arms, feet, ankles, or lower legs

Word of Advice

You may use moisturizing creams and lotions during the treatment with this ointment but remember that these products should not be used within two hours of applying Tbis 0.1% Ointment. Do not eat grapefruit or drink grapefruit juice while you are using tacrolimus. Do not drink alcohol while you are using this medicine. This medicine may interfere with the vaccine. Ask your healthcare professional before getting a flu shot or other vaccines. Apply sunscreen with a good SPF and wear protective clothing before you step out in the sun.  Your doctor may advise you to take certain tests to monitor the effectiveness and side effects of the therapy. Keep all your appointments regularly. 


Q 1. What is Tbis 0.1% Ointment used for?

Tbis 0.1% Ointment is indicated to treat moderate to severe atopic dermatitis. Atopic Dermatitis is a skin condition where the immune system reacts excessively, leading to inflammation (itching, redness, and irritation).

Q 2. Who should not use Tbis 0.1% Ointment?

Children below the age of 2 years and people who have experienced hypersensitivity to Tacrolimus or macrolide antibiotics should not use Tbis 0.1% Ointment. Tbis 0.1% Ointment 0.1% W/W is not recommended for children below the age of 16 years.

Q 3. Can you consume alcohol during treatment with Tbis 0.1% Ointment?

Drinking alcohol while on treatment with Tbis 0.1% ointment may lead to flushing, redness, and heat sensation in the face and skin. Hence, alcohol consumption is not recommended.

Q 4. What should you not use with Tbis 0.1% Ointment?

Inform your healthcare provider you are taking or have taken oral corticosteroids, immunosuppressants, moisturizers, or other cosmetics before starting treatment with Tbis 0.1% Ointment. Ensure you don’t apply moisturizing lotions or creams within two hours of applying Tbis 0.1% Ointment.

Q 5. What should you avoid while using Tbis 0.1% Ointment?

Avoid sun exposure, as Tbis 0.1% makes your skin sensitive. Wear protective clothing and use an effective sunscreen to prevent skin damage from sun exposure. Do not go near smoke or flame after applying Tbis 0.1% Ointment.

Q 6. How long does Tbis 0.1% Ointment take to work?

Tbis 0.1% Ointment shows improvement on the skin within one week of application. Discuss alternative treatment with your healthcare provider if you do not notice any changes within two weeks of starting the treatment.

Q 7. Should I follow any dietary restrictions while taking Tbis 0.1%?

Tbis 0.1% can interact with certain foods and beverages, particularly grapefruit and grapefruit juice, which may increase the levels of tacrolimus in the blood. Discussing dietary restrictions and potential interactions with your healthcare provider is important.

Fact Box of Tbis 0.1% Ointment

Molecule name: Tacrolimus

Therapeutic class: Immunomodulating agent

Pharmacological class: Calcineurin inhibitors

Indications: Atopic Dermatitis


  1. Package Leaflet: Information for the User Protopic ® 0.1% Ointment Tacrolimus Monohydrate.; Revised June 2021. Accessed May 25, 2023.
  2. PROTOPIC ® (Tacrolimus) Ointment 0.03%, Ointment 0.1%. Revised June 2011. Accessed May 25, 2023.
  3. Alan M. Krensky, Jamil R. Azzi, and David A. Hafler, Goodman & Gilman’s Pharmacological Basis of Therapeutics, Immunosuppressants and Tolerogens, 13th Edition, 2018, 637-653.


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