TERIFRAC 750MCG INJECTION

Introduction:

Terifrac 750mcg Injection consists of the active ingredient Teriparatide. It is used to treat bone loss (osteoporosis) in men and postmenopausal women at high risk of fracture. It is a synthetic form of the parathyroid hormone naturally produced in the body. This Injection is the only drug that works on bone formation, while the other drugs work on bone resorption.

Terifrac 750mcg Injection uses:

• Treatment of bone loss (osteoporosis) in men and postmenopausal women

How Terifrac 750mcg Injection Works:

The parathyroid hormone takes part in the process of new bone formation. Terifrac 750mcg Injection is a synthetic form of the parathyroid hormone 1-34. This Injection works by binding specifically to the receptors present on the surface of the cells. This leads to improvement in skeletal mass, markers of bone formation and resorption and bone strength. The new bone appears structurally normal and thus reduces the risk of fractures.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Keep Terifrac 750mcg Injection out of sight and reach of children. Store in a refrigerator (2-8˚C). Do not freeze. Do not use the injection if the contents are cloudy or coloured.

References:

1. Eli Lilly and Company, Lilly USA, LLC, [Revised on Apr 2021] [Accessed on 1st Mar 2022], https://pi.lilly.com/us/forteo-pi.pdf
2. Thornton & Ross Ltd, Electronic Medicines Compendium (emc), [Revised on May 2019] [Accessed on 7th Apr 2021],  https://www.medicines.org.uk/emc/files/pil.10780.pdf
3. Daniel D. Bickle, Agents that affect bone mineral homeostasis, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 772-791.
4. KD Tripathi, Hormones and Drugs Affecting Calcium Balance, Essentials of Medical Pharmacology, 8th Edition, 2019, 360-372.

How to use Terifrac 750mcg Injection:

Terifrac 750mcg cartridge is intended for subcutaneous administration, either into the thigh or abdominal wall. It can be taken with or without food. This treatment is not supposed to be continued for more than 2 years.

Safety Advice:

Pregnancy:

Terifrac Injection 3ml is not intended for use in pregnancy. Consult your physician for advice.

Breastfeeding: 

Discuss with your physician before taking this injection if you are breastfeeding or planning to breastfeed your child.

Kidney:

Terifrac 750mcg Injection is not recommended in patients with kidney disorders. Consult your physician for advice.

Driving:

Terifrac 750mcg Injection might cause dizziness. Do not drive or use machines if you feel dizzy.

Others: 

• Inform your physician if you have been told that you have bone cancer, bone metabolic diseases or if you are receiving radiation therapy involving your bones.
• Consult your physician to monitor your blood calcium levels regularly to detect hypercalcemia.
• Inform your physician if you have orthostatic hypotension or allergic reaction to teriparatide or its ingredients.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Hypercalcemia
• Allergic reactions that affect skin and breathing.
• Skin reactions such as rashes, bruising, swelling and itching, at the site of injection.

Common:

• Arthralgia
• Nerve Pain
• Nausea
• Sickness
• Headache
• Dizziness
• Increased sweating
• Breathlessness
• Muscle cramps
• Increase in blood cholesterol levels
• Chest pain
• Burning sensation below the breast bone
• Anaemia