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TOPOTEC 2.5MG INJECTION_1
TOPOTEC 2.5MG INJECTION_2
TOPOTEC 2.5MG INJECTION_1
17% Off

TOPOTEC 2.5MG INJECTION

Prescription Required

Salt Composition : Topotecan

Manufacturer : UNITED BIOTECH PVT LTD

Origin of Medicine : India

MRP: 5435
Price :4502
You Save :933 (17%)

1 Vial(s) Of 2.5ml


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Introduction to Topotec 2.5mg Injection

Topotec 2.5mg Injection consists of the active ingredient as Topotecan. It is indicated to treat cancer in the ovaries and lungs that recurred after finishing the chemotherapy treatment course. When surgery or radiotherapy does not work, this medicine is used to treat advanced cervical cancer along with another anticancer drug called cisplatin. It is not recommended for pediatric use. Patients should avoid consuming grapefruit or grapefruit juice while taking Topotec 2.5mg Injection, as it can increase the amount of the drug in the body and potentially lead to side effects.
Previously, if you have faced any allergic reactions to Topotec 2.5mg Injection or any of its ingredients, tell your physician before taking this medicine. Report to your doctor instantly if you experience unusual bruising or bleeding, fever, severe stomach ache, or infections. While Topotec 2.5mg Injection can cause side effects, they are often manageable with medication or other supportive therapies. The benefits of this medicine in treating cancer often outweigh the potential risks of side effects, and many patients have experienced successful outcomes with this treatment.


Uses of Topotec 2.5mg Injection

Topotec 2.5mg Injection is indicated to treat the following conditions:

  • Ovarian cancer
  • Small cell lung cancer
  • Advanced cervical cancer

Therapeutic Effects of Topotec 2.5mg Injection

Topotec 2.5mg Injection works by interfering with the normal function of DNA, which prevents cancer cells from dividing and growing. This helps to slow or stop the growth of cancer cells, which can lead to the regression of tumors and an improvement in cancer symptoms.


Interaction of Topotec 2.5mg Injection with other drugs

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Topotec 2.5mg Injection and reduce effectiveness by causing undesirable side effects.


More Information about Topotec 2.5mg Injection

  • Store in a refrigerator at 2-8°C.
  • Do not freeze.
  • Protected from light.
  • Keep it in its original packaging until it is ready to be used.
  • Keep out of the reach of children and pets.
  • Should be disposed of properly.

How to consume Topotec 2.5mg Injection

Topotec 2.5mg Injection is typically administered by a healthcare provider as an intravenous (IV) infusion in a clinical setting. The dosage and frequency of infusions will vary depending on the patient's individual medical condition, age, weight, and other factors. You should not take a double dose to make up for the second dose.


 


Safety Advices for Topotec 2.5mg Injection

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Pregnancy

  

Topotec 2.5mg Injection is unsafe during pregnancy as it can cause fetal harm. It is recommended to avoid this medication during pregnancy.

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Breast Feeding

  

It is not clear whether Topotec 2.5mg Injection is excreted in human milk or not. So you should consult a doctor before taking this medication if you are a breastfeeding mother.

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Lungs

  

Topotec 2.5mg Injection is used to treat small-cell lung cancer, which is a type of lung cancer that is often aggressive and difficult to treat. Patients with pre-existing lung conditions, such as chronic obstructive pulmonary disease (COPD) or asthma, should discuss the risks and benefits of treatment with their healthcare provider.

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Liver

  

Topotec 2.5mg Injection is primarily metabolized in the liver, so inform your healthcare provider if you have any liver problems or diseases. This medication may also increase liver enzymes, which can be a sign of liver damage or inflammation. Patients taking this medication require regular blood tests to monitor liver function.

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Alcohol

  

It is recommended to avoid consuming alcohol while taking Topotec 2.5mg Injection, as alcohol can increase the risk of certain side effects associated with the medication, such as stomach ulcers or gastrointestinal bleeding.

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Driving

  

Patients receiving Topotec 2.5mg Injection should be advised to avoid driving or operating machinery if they experience side effects such as fatigue, dizziness, or blurred vision, impairing a patient's ability to drive or operate machinery safely.


Side Effects of Topotec 2.5mg Injection

Like all medications, Topotec 2.5mg Injection can cause side effects, although not everyone who takes it will experience them. 

Serious:

  • Bone marrow suppression (increased risk of infection, anemia, and bleeding)
  • Gastrointestinal toxicity (diarrhea, vomiting, and dehydration)
  • Lung toxicity (difficulty breathing, coughing, and chest pain)
  • Neurological toxicity (numbness or tingling in the hands or feet, confusion, and seizures)
  • Cardiac toxicity (changes in heart rate and blood pressure)
  • Allergic reactions (swelling of the face or throat, difficulty breathing, and hives)
  • Liver toxicity (yellowing of the skin or eyes, dark urine, and abdominal pain)

Common:

  • Nausea
  • Vomiting
  • Diarrhea
  • Fatigue
  • Anemia
  • Hair loss
  • Decreased appetite
  • Mouth sores
  • Fever
  • Headache
  • Insomnia
  • Dizziness
  • Muscle weakness
  • Back pain
  • Difficulty breathing

Word of Advice

If you are receiving treatment with Topotec 2.5mg Injection, report any side effects or concerns promptly. If you are pregnant or planning to become pregnant, or if you are breastfeeding, it is important to discuss the risks and benefits with your healthcare provider. Reproductive-age women should use effective birth control during the treatment and for at least two weeks after their last dose. You should avoid consuming grapefruit while taking this medication, as it decreases the absorption of the drug in the body and causes severe side effects.

Protect your skin from the sun when going outside during treatment with this medication. Making lifestyle changes, such as quitting smoking, maintaining a healthy weight, and eating a healthy diet, can also help support your overall health and reduce the risk of complications associated with cancer. Additionally, seeking support from family members, friends, or support groups can provide patients with emotional support and help them cope with the challenges of cancer treatment.


FAQs

Q 1. Can Topotec 2.5mg Injection be given to elderly patients?

Yes, Topotec 2.5mg Injection can be given to elderly patients. However, elderly patients may be at higher risk of certain side effects, such as bone marrow suppression and gastrointestinal toxicity. The dosage may need to be adjusted for elderly patients.

Q 2. Can Topotec 2.5mg Injection cause fertility problems?

Topotec 2.5mg Injection can cause temporary or permanent infertility in both men and women. Patients should discuss their fertility options with their healthcare provider before starting treatment.

Q 3. Can Topotec 2.5mg Injection cause nerve damage?

Topotec 2.5mg Injection can cause nerve damage, which may lead to symptoms such as tingling, numbness, or weakness in the hands and feet. Patients should notify their healthcare provider if they experience any new or worsening neurological symptoms.

Q 4. How Topotec 2.5mg Injection will affect my blood?

Topotec 2.5mg Injection can affect your blood count by decreasing the number of white blood cells, red blood cells, and platelets in your blood. This can increase the risk of infections, anemia, and bleeding. Your healthcare provider will monitor your blood counts regularly during treatment and may adjust your dosage or delay treatment based on your blood count results.

Q 5. What can I do to manage gastrointestinal toxicity caused by Topotec 2.5mg Injection?

Your healthcare provider medications to help manage nausea, vomiting, and diarrhea caused by Topotec 2.5mg Injection. You can also try eating small, frequent meals and drinking plenty of fluids to help alleviate these symptoms.


Fact Box of Topotec 2.5mg Injection

Molecule name: Topotecan

Therapeutic class: Anticancer

Pharmacological class:  Antineoplastic


 

Indications:  

1. Ovarian cancer

2. Small cell lung cancer

3. Advanced cervical cancer


References

  1. Accord Healthcare Limited, Electronic Medicines Compendium (EMC), [Revised on Feb 2021] [Accessed on 24th April 2023], https://www.medicines.org.uk/emc/files/pil.4159.pdf
  2. Accord Ltd, US Food & Drug Administration, [Revised on Sep 2018] [Accessed on 24th April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/020671s023lbl.pdf
  3. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976

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