• Advanced melanoma (type of skin cancer)
• Advanced kidney cancer
• Liver cancer
• Colorectal cancer
• Non-small cell lung cancer (type of lung cancer)

Yervoi 50mg Injection is a medication that works by helping the body's immune system to attack cancer cells. Specifically, it blocks a protein called CTLA-4, which normally helps regulate immune cells' activity called T cells. By blocking CTLA-4, Yervoi 50mg Injection allows T cells to become more active and better able to recognize and destroy cancer cells. It takes the brakes off the immune system, allowing it to fight cancer better. Doing so can help shrink tumors and improve survival in some patients with advanced melanoma.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Yervoi 50mg Injection and reduce effectiveness by causing undesirable side effects.

• Yervoi 50mg Injection should be stored at room temperature between 20-25°C (68-77°F).
• Keep away from heat, moisture, and light.
• Store in an original package.
• Keep out of reach of children and pets.

Yervoi 50mg Injection is typically administered by a healthcare professional through an intravenous (IV) infusion. The medication is prepared as a solution and given for about 90 minutes. The dose will depend on factors such as the patient's weight and overall health and the specific cancer being treated. Treatment is typically given in cycles, with each cycle consisting of several infusions given over weeks or months. If you miss a dose, then it is important to contact your healthcare provider as soon as possible to discuss your options. The timing and frequency of doses can be critical in achieving the maximum benefit from the medication.

Like all medications, Yervoi 50mg Injection can cause side effects, although not everyone who takes it will experience them. 

Serious:

• Inflammation of the colon (colitis)
• Inflammation of the liver (hepatitis)
• Inflammation of the lungs (pneumonitis)
• Inflammation of the pituitary gland (hypophysitis)
• Inflammation of the skin (dermatitis)
• Nerve damage (neuropathy)
• Hypothyroidism
• Adrenal insufficiency
• Diabetes

Common:

• Fatigue
• Diarrhea
• Itching
• Rash
• Nausea
• Loss of appetite
• Headache
• Insomnia
• Muscle pain
• Joint pain

Yervoi 50mg Injection is a powerful medication that can have potentially serious side effects. Therefore, following your healthcare provider's instructions for taking the medication and reporting any side effects or changes in your health is important. If you feel any infusion reaction, then immediately contact your doctor. If you are a woman who could become pregnant, use effective birth control during the treatment and for at least three months after the last dose. You need to talk to your physician if you are on a salt-controlled diet this medication contains sodium. It is recommended that patients undergoing cancer treatment eat a diet rich in fruits, vegetables, whole grains, and lean proteins and limit their intake of processed and high-fat foods. Drinking plenty of water and staying hydrated is also important.

1. Bristol-Myers Squibb Company, US Food and Drug Administration, [Revised on May 2020] [ Accessed on 15 April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/125377s110lbl.pdf
2. Bristol-Myers Squibb Pharma EEIG, Electronic medicines compendium (emc), [Revised on Jan 2021] [ Accessed on 15th April], https://www.medicines.org.uk/emc/files/pil.4683.pdf
3. Matthew D Hellmann et al; Nivolumab plus Yervoi 50mg Injection in Advanced Non-Small-Cell Lung Cancer; The New England Journal of Medicine; Published on Nov 2019; Accessed on 15th April 2023]; https://pubmed.ncbi.nlm.nih.gov/31562796/