This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Acalabrutinib is an anticancer medicine containing the active constituent acalabrutinib. It belongs to a class of drugs called Bruton's tyrosine kinase (BTK) inhibitors. Acalabrutinib was first approved by the U.S. Food and Drug Administration (FDA) on October 31, 2017, to treat adult patients with mantle cell lymphoma who have received at least one prior therapy. It was later approved by the FDA on August 17, 2020, for the treatment of adult patients with chronic lymphocytic leukemia or small lymphocytic lymphoma.

Mechanism of Action of undefined

The mechanism of acalabrutinib, inhibits the activity of Bruton's tyrosine kinase (BTK). This protein is essential for the survival and growth of cancer cells in certain types of lymphomas and leukemias. By blocking BTK, it can help to slow down or even stop the growth and spread of cancer cells, which can lead to a reduction in tumor size, an improvement in symptoms, and a delay in disease progression.

Uses of undefined

Acalabrutinib is used to treat mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and small lymphocytic lymphoma (SLL). MCL, CLL, and SLL are cancers of the white blood cells called lymphocytes that are part of the immune system.

undefined Drug administaration and Dosage available

Acalabrutinib is typically administered through injection by a healthcare provider. The specific method of administration may vary depending on the condition being treated and the healthcare provider's instructions. If a dose is missed, the patient should contact their healthcare provider for further instructions.

Warnings, Precautions and Side Effects of undefined


Acalabrutinib carries several warnings regarding its potential risks and side effects. The medication may increase the risk of serious infections, bleeding, irregular heart rhythms, and lung inflammation. It may also increase the risk of developing other types of cancer, particularly skin cancer. Patients with a history of heart disease, bleeding disorders, or liver disease may be at increased risk of experiencing complications while taking it.


Before starting treatment, patients should inform their healthcare provider of any medical conditions, including heart disease, bleeding disorders, or liver disease. It can increase the risk of bleeding, so patients should avoid activities that may increase the risk of injury, such as contact sports, and inform their healthcare provider if they experience any unusual bleeding or bruising. Patients should also inform their dentist and healthcare provider if they need a dental procedure, as acalabrutinib can increase the risk of bleeding.

Side Effects

Common side effects may include headache, diarrhea, fatigue, and muscle aches. Serious side effects may include bleeding, infections, heart rhythm problems, and lung inflammation. Acalabrutinib may also increase the risk of developing other types of cancer.

Word Of Advice

If you have been prescribed Acalabrutinib, it is important to carefully read and understand the warnings and precautions associated with the medication. Patients require monitoring for signs of an allergic reaction. It can cause high blood pressure. Patients should check their blood pressure regularly. Report to your doctor if you develop a lesion or change in the appearance of an area on the skin. It increases the risk of infection, so patients should avoid close contact with infected persons. Patients with diabetes require close monitoring during treatment. Pregnancy and breastfeeding should be avoided during treatment. Always maintain a healthy and balanced diet to support your overall health and well-being.

Frequently Asked Question


  1. AstraZeneca, Electronica medicines compendium (EMC), [Revised on Dec 2020], [ Accessed on 5th May 2023],
  2. AstraZeneca, US Food and Drug Administration, [ Revised on Oct 2017], [ Accessed on 5th May 2023],
  3. John C Byrd et al; Acalabrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia: updated phase 2 results; Blood; Published on April 2020; [Accessed on5th May 2023];


The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.