This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Acotiamide is a gastroprokinetic drug developed by the U.S. Food And Drug Administration and initially approved for treating functional dyspepsia (indigestion).

Mechanism of Action of undefined

Acotiamide works by increasing the release of acetylcholine, a neurotransmitter that plays a role in stimulating the muscles of the gastrointestinal tract. This enhanced release of acetylcholine can help improve gastric emptying and reduce symptoms associated with functional dyspepsia, such as bloating and discomfort.

Uses of undefined

Acotiamide is used to treat gastrointestinal conditions, primarily functional dyspepsia. Functional dyspepsia is a common digestive disorder caused by chronic or recurrent upper abdominal discomfort or pain, often accompanied by symptoms such as bloating, early satiety (feeling full quickly after eating), and nausea. It's a condition in which no underlying structural or metabolic cause can be identified.

undefined Drug administaration and Dosage available

Take the Acotiamide as your physician advises. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.

Warnings, Precautions and Side Effects of undefined

Warnings

Do not use this drug if you have a known allergy or sensitivity to it or any components in the medication. No clinical study was performed on the safety of Acotiamide in breastfeeding and pregnant women. Consult your doctor for more advice. Individuals with severe kidney impairment may require adjusted dosages or closer monitoring when taking this drug.

Precautions

The safety and effectiveness of this medicine in children and infants have not been established. This medication is prescribed for adults, so its use in pediatric populations may require careful consideration and monitoring.

Side Effects

The side effects known to occur commonly during the treatment with Acotiamide are diarrhea, headache, and dizziness.

Word Of Advice

Diarrhea can lead to dehydration and fluid loss. It's necessary to drink plenty of fluids, such as water, oral rehydration solutions, or clear broths when using Acotiamide to address diarrhea. Proper hydration helps replace lost fluids and electrolytes and supports the body's recovery.

Frequently Asked Question

References

  1. Acofide Tablets 100 mg - Report on the deliberation results - PMDA. [Accessed date 02 Sep 2023]; https://www.pmda.go.jp/files/000153467.pdf
  2. Masahiro Ueda et al; Profile of acotiamide in the treatment of functional dyspepsia; Clinical and Experimental Gastroenterology 2016; [Accessed date 02 Sep 2023]; http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4827886/
  3. Jan Tack, Pieter Janssen; Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia; Expert opinion on Investigational drugs 2011; [Accessed date 02 Sep 2023]; https://pubmed.ncbi.nlm.nih.gov/21417958/
  4. Guoguang Xiao et al.; Efficacy and safety of acotiamide for the treatment of functional dyspepsia: systematic review and meta-analysis; The Scientific World Journal 2014; [Accessed date 02 Sep 2023]; http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4146483/
  5. Kazuyoshi Yoshii et al.; Mechanism for distribution of acotiamide, a novel gastroprokinetic agent for the treatment of functional dyspepsia, in rat stomach; Journal of Pharmaceutical Sciences 2011;[Accessed date 02 Sep 2023]; https://pubmed.ncbi.nlm.nih.gov/21630282/

Disclaimer

The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.