ACOTIAMIDE

Written By:Sakshi Anil MoreB. Pharm Reviewed By:Dr. Tejashwin AdigaMBBS

Last updated on 31 Mar 2026 | 09:31 AM (IST)

ACOTIAMIDE

Background and Date of approval ACOTIAMIDE

Acotiamide is a gastroprokinetic drug developed by the U.S. Food And Drug Administration and initially approved for treating functional dyspepsia (indigestion).

Uses of ACOTIAMIDE

Acotiamide is used to treat gastrointestinal conditions, primarily functional dyspepsia. Functional dyspepsia is a common digestive disorder caused by chronic or recurrent upper abdominal discomfort or pain, often accompanied by symptoms such as bloating, early satiety (feeling full quickly after eating), and nausea. It's a condition in which no underlying structural or metabolic cause can be identified.

How is ACOTIAMIDE administered?

Take the Acotiamide as your physician advises. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.

Side Effects of ACOTIAMIDE

The side effects known to occur commonly during the treatment with Acotiamide are diarrhea, headache, and dizziness.

Warnings

Do not use this drug if you have a known allergy or sensitivity to it or any components in the medication. No clinical study was performed on the safety of Acotiamide in breastfeeding and pregnant women. Consult your doctor for more advice. Individuals with severe kidney impairment may require adjusted dosages or closer monitoring when taking this drug.

Precautions

The safety and effectiveness of this medicine in children and infants have not been established. This medication is prescribed for adults, so its use in pediatric populations may require careful consideration and monitoring.

Word of Advice

Diarrhea can lead to dehydration and fluid loss. It's necessary to drink plenty of fluids, such as water, oral rehydration solutions, or clear broths when using Acotiamide to address diarrhea. Proper hydration helps replace lost fluids and electrolytes and supports the body's recovery.

Frequently Asked Questions

Q1.

How does Acotiamide work to treat functional dyspepsia?

Acotiamide is a prokinetic agent, which means it enhances the motility of the gastrointestinal tract. It does this by inhibiting the breakdown of acetylcholine, a neurotransmitter that stimulates the contraction of muscles in the digestive system. By increasing the levels of acetylcholine, this drug helps improve the movement of food through the stomach and small intestine, which can relieve symptoms of functional dyspepsia.

Q2.

Is Acotiamide available over-the-counter (OTC)?

Acotiamide is available by prescription and is not commonly found as an over-the-counter (OTC) medication. It is important to consult with a physician for an accurate diagnosis and prescription.

Q3.

Are there any side effects associated with acotiamide?

The common side effects of Acotiamide may include headache, diarrhea, and dizziness. Not everyone will experience these side effects, and they are usually mild. If you experience severe side effects, contact your physician.

Q4.

Is Acotiamide safe during pregnancy and breastfeeding?

The safety of Acotiamide during pregnancy and breastfeeding has not been well studied. If you are pregnant, planning to become pregnant, or breastfeeding, it is highly advised to discuss the benefits and risks of using this drug with your physician before taking the medication.

Q5.

Can I take other medications with Acotiamide?

Inform your physician about all the medications, supplements, and over-the-counter drugs you are taking, as there may be potential interactions with Acotiamide. Your provider can assess the safety and efficacy of combining this drug with other medications and make appropriate recommendations.

References

Acofide Tablets 100 mg - Report on the deliberation results - PMDA. [Accessed date 02 Sep 2023]; https://www.pmda.go.jp/files/000153467.pdf
Masahiro Ueda et al; Profile of acotiamide in the treatment of functional dyspepsia; Clinical and Experimental Gastroenterology 2016; [Accessed date 02 Sep 2023]; http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4827886/
Jan Tack, Pieter Janssen; Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia; Expert opinion on Investigational drugs 2011; [Accessed date 02 Sep 2023]; https://pubmed.ncbi.nlm.nih.gov/21417958/
Guoguang Xiao et al.; Efficacy and safety of acotiamide for the treatment of functional dyspepsia: systematic review and meta-analysis; The Scientific World Journal 2014; [Accessed date 02 Sep 2023]; http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4146483/
Kazuyoshi Yoshii et al.; Mechanism for distribution of acotiamide, a novel gastroprokinetic agent for the treatment of functional dyspepsia, in rat stomach; Journal of Pharmaceutical Sciences 2011;[Accessed date 02 Sep 2023]; https://pubmed.ncbi.nlm.nih.gov/21630282/

Disclaimer

The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.

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