Alfuzosin Hcl + Dutasteride contains two active ingredients in one tablet. One of the active substances is Alfuzosin Hcl, which belongs to the group of medications called alpha-adrenoreceptor antagonists. The other active substance is Dutasteride belonging to the group of medications called 5-alpha-reductase inhibitors. The FDA approved this combination to treat Benign prostatic hyperplasia (BPH).

Alfuzosin Hcl + Dutasteride is used to treat symptoms associated with benign prostatic hyperplasia in men (enlarged prostate). It refers to a non-cancerous prostate gland growth, which can result in urinary problems such as difficulty in passing urine, frequent or urgent need to urinate, and urinary dribbling.

Your doctor will decide the dose and duration of Alfuzosin Hcl + Dutasteride based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. Take the tablet at the same time every day, with or without food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water. 

The common side effects of Alfuzosin Hcl + Dutasteride are impotence, decreased libido, ejaculation disorder, headache, nausea, abdominal pain, upper respiratory tract infection, breast enlargement in male, and breast tenderness in male.

Do not take Alfuzosin Hcl + Dutasteride if you have severe liver disease or hepatic impairment. This drug is metabolized in the liver, so severe liver dysfunction can affect the clearance of these medications and potentially lead to adverse effects. This tablet should be used cautiously in individuals with moderate to severe kidney impairment. Dose adjustments may be necessary in these cases, and close monitoring of renal function is advised. If you are scheduled for cataract surgery or any other eye procedure, notify your ophthalmologist that you are taking this tablet. The medication has been associated with intraoperative floppy iris syndrome (IFIS), which can complicate the surgical procedure.

Alfuzosin Hcl + Dutasteride can cause a drop in blood pressure, leading to orthostatic hypotension (a sudden drop in blood pressure upon standing up). If a person has a history of orthostatic hypotension or is prone to low blood pressure, this drug should be used with caution. It is not recommended for adolescents and children under the age of 18. This drug is specifically indicated for use in men and should not be taken by women.

This medicine can lower blood pressure, which may cause dizziness or fainting, especially when changing positions (from lying down to standing up). To minimize the risk, rise slowly and gradually from a sitting or lying position. It is important to maintain good hydration while taking Alfuzosin Hcl + Dutasteride. Drink adequate water throughout the day unless otherwise advised by your healthcare provider. If you miss a dosage, take it as soon as you remember. If it is almost time for the next dose, skip the missing dose. Do not take a double dose to compensate for a missed dose. 

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6. KD Tripathi, Essentials of Medical Pharmacology, Antiadrenergic Drugs (Adrenergic Receptor Antagonists) and Drugs for Glaucoma, 7th edition, 2013, 142.
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The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.