This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Alfuzosin Hcl + Dutasteride contains two active ingredients in one tablet. One of the active substances is Alfuzosin Hcl, which belongs to the group of medications called alpha-adrenoreceptor antagonists. The other active substance is Dutasteride belonging to the group of medications called 5-alpha-reductase inhibitors. The FDA approved this combination to treat Benign prostatic hyperplasia (BPH).

Mechanism of Action of undefined

Alfuzosin is an alpha-1 adrenergic receptor blocker that works by selectively relaxing the smooth muscles in the prostate gland and the bladder neck. This helps relieve urinary symptoms caused by BPH. Dutasteride is a 5-alpha-reductase inhibitor that reduces the production of dihydrotestosterone (DHT), a hormone responsible for prostate enlargement.

Uses of undefined

Alfuzosin Hcl + Dutasteride is used to treat symptoms associated with benign prostatic hyperplasia in men (enlarged prostate). It refers to a non-cancerous prostate gland growth, which can result in urinary problems such as difficulty in passing urine, frequent or urgent need to urinate, and urinary dribbling.

undefined Drug administaration and Dosage available

Your doctor will decide the dose and duration of Alfuzosin Hcl + Dutasteride based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. Take the tablet at the same time every day, with or without food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water. 

Warnings, Precautions and Side Effects of undefined


Do not take Alfuzosin Hcl + Dutasteride if you have severe liver disease or hepatic impairment. This drug is metabolized in the liver, so severe liver dysfunction can affect the clearance of these medications and potentially lead to adverse effects. This tablet should be used cautiously in individuals with moderate to severe kidney impairment. Dose adjustments may be necessary in these cases, and close monitoring of renal function is advised. If you are scheduled for cataract surgery or any other eye procedure, notify your ophthalmologist that you are taking this tablet. The medication has been associated with intraoperative floppy iris syndrome (IFIS), which can complicate the surgical procedure.


Alfuzosin Hcl + Dutasteride can cause a drop in blood pressure, leading to orthostatic hypotension (a sudden drop in blood pressure upon standing up). If a person has a history of orthostatic hypotension or is prone to low blood pressure, this drug should be used with caution. It is not recommended for adolescents and children under the age of 18. This drug is specifically indicated for use in men and should not be taken by women.

Side Effects

The common side effects of Alfuzosin Hcl + Dutasteride are impotence, decreased libido, ejaculation disorder, headache, nausea, abdominal pain, upper respiratory tract infection, breast enlargement in male, and breast tenderness in male.

Word Of Advice

This medicine can lower blood pressure, which may cause dizziness or fainting, especially when changing positions (from lying down to standing up). To minimize the risk, rise slowly and gradually from a sitting or lying position. It is important to maintain good hydration while taking Alfuzosin Hcl + Dutasteride. Drink adequate water throughout the day unless otherwise advised by your healthcare provider. If you miss a dosage, take it as soon as you remember. If it is almost time for the next dose, skip the missing dose. Do not take a double dose to compensate for a missed dose. 

Frequently Asked Question


  1. Sanofi, Electronic medicines compendium (EMC), [Revised on Sept 2020] [ Accessed on 13th  June 2023],
  2. Rivopharm UK Ltd, US Food and Drug Administration, [Revised on March 2017] [ Accessed on 13th  June 2023],
  3. Ciplamed; Accessed on 13th  June 2023;
  4. Package leaflet: Information for the user -Xatral 10mg tablets. [Revised on Dec 2019],  [ Accessed on 13th  June 2023],
  5. Package leaflet: Information for the user -Xatral 10mg tablets. [Revised on Feb 2019],  [ Accessed on 13th  June 2023],
  6. KD Tripathi, Essentials of Medical Pharmacology, Antiadrenergic Drugs (Adrenergic Receptor Antagonists) and Drugs for Glaucoma, 7th edition, 2013, 142.
  7. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Androgens, 12th edition, 2011, 1205.


The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.