This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

The U.S. FDA approved Sotalol in 1996 and used to treat erectile dysfunction (ED), peripheral arterial disease (PAD), patent ductus arteriosus (PDA) in Infants and also for diagnostic purposes.

Mechanism of Action of undefined

Alprostadil binds to specific receptors on smooth muscle cells in blood vessels and various tissues. When it binds to these receptors, it triggers biochemical events that lead to vasodilation. It relaxes the smooth muscles in blood vessel walls, particularly in the penis, when used for erectile dysfunction. It involves promoting the relaxation of smooth muscle cells, improving blood flow to specific body areas, depending on its intended use.

Uses of undefined

It may be used to improve blood flow in patients with peripheral arterial disease (PAD), a condition in which blood flow to the extremities (usually the legs) is reduced. In newborns with certain heart conditions, such as PDA, it can open a blood vessel called the ductus arteriosus. It can also be used in diagnostic tests to assess blood flow in specific body areas, such as during penile Doppler ultrasound studies to evaluate erectile function.

undefined Drug administaration and Dosage available

Alprostadil is available as an injection and can be administered through intracavernosal injection (into the penis) by the healthcare provider on scheduled appointments. Your doctor will decide the most suitable dosage for your case according to your age and physical circumstances.

Warnings, Precautions and Side Effects of undefined


Alprostadil can cause priapism, a painful and prolonged erection lasting longer than four hours. Long-term use of this medication for erectile dysfunction (ED) can lead to penile fibrosis, where the penis becomes scarred and may affect erectile function. While rare, severe allergic reactions to this medication can occur. It can cause a drop in blood pressure, potentially leading to dizziness or fainting. It may increase the risk of bleeding, particularly in individuals with bleeding disorders or those taking anticoagulant medications (blood thinners).


If priapism occurs, seek immediate medical attention, as priapism can damage the penis if not treated promptly. Seek medical help if you experience rash, itching, swelling, severe dizziness, or difficulty breathing. Use caution if you have low blood pressure or are taking medications that lower it. Individuals with underlying heart conditions should use it cautiously, as it can have cardiovascular effects. Following the prescribed dosage and administration instructions for this medication is essential, and consult with a healthcare provider if you have concerns or experience any adverse effects.

Side Effects

The common side effects that are experienced while you are on the treatment with Alprostadil are pain or discomfort, penile burning or tingling, urethral irritation, headache, flushing, flu-like symptoms. Report your doctor immediately if you have priapism, penile fibrosis, allergic reactions, low blood pressure, cardiovascular effects, bleeding.

Word Of Advice

Use Alprostadil under medical supervision to determine the right dose and method. Watch for priapism (prolonged erection) and seek immediate help if it occurs. Inform your healthcare provider of any underlying medical conditions, such as bleeding disorders, heart conditions, or liver disease, as dose adjustments or special precautions may be necessary. Be cautious with penile abnormalities or predisposition to priapism. Monitor the use of this medication in infants and consider benefits versus risks. Avoid it if you are allergic to it or its components. Use alcohol with caution, and be aware of medication interactions. Assess how this medication affects you before driving or operating machinery. Discuss its use during pregnancy and breastfeeding with your healthcare provider. Follow storage instructions for safe and effective use.

Frequently Asked Question


  1. Pfizer Limited, Electronic Medicines Compendium (EMC), [Revised on Apr 2021] [Accessed on 3rd Oct 2023],
  2. John Hwa, Kathleen Martin, The Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, & Related Compounds, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 321-338.


The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.