The U.S. FDA-approved Ambrisentan + Tadalafil for pulmonary arterial hypertension (PAH) on June 15, 2007. Ambrisentan + Tadalafil belongs to the medication class known as an antihypertensive. Tadalafil is a type of medication called phosphodiesterase-5 (PDE5) inhibitor, whereas Ambrisentan belongs to an endothelin receptor antagonist.  

Ambrisentan + Tadalafil treats pulmonary arterial hypertension (PAH). It functions by inducing relaxation in the blood vessels within the lungs.

Take the Ambrisentan + Tadalafil as your physician advises. Usually, the tablets will be taken with or without food. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.

The most common side effects of Ambrisentan + Tadalafil are redness of skin, vomiting, chest pain, ringing in the ears, abnormal liver function, constipation. Serious side effects while taking Ambrisentan + Tadalafil are oedema, anaemia, hypotension, allergic reactions, sudden loss of vision, priapisms, or weakness, problems with eyesight, including blurry vision.

Ambrisentan + Tadalafil should not be consumed if you are allergic to Ambrisentan + Tadalafil or any of its ingredients in the medication. Avoid taking this medicine if you have liver conditions or low blood pressure. Do not consume this medicine if you are pregnant or breastfeeding, if you use organic nitrates or GC stimulators, have a history of vision loss in one eye, or if you have idiopathic pulmonary fibrosis (IPF). Before beginning the treatment, notify your doctor if you have any issues such as penis deformation, swelling in the extremities, prolonged or painful erection (priapism), cancer (leukemia, multiple myeloma), severe kidney problems, abnormality of red blood cells, or loss of hearing.

Notify your doctor if you are pregnant, planning to get pregnant, or think you may be pregnant or breastfeeding. This medicine is not advised to use in children under 18 years old. Before starting the treatment, inform your doctor if you have hypotension, a history of heart failure, or severe liver disease. Inform your doctor if you recently had a stroke or myocardial infarction. Notify your doctor if you have or have had lung conditions, anemia, or edema (fluid retention). Your doctor will conduct blood tests to check for anemia and assess the liver's functionality. The exact impact of the medicine during driving or operating machinery is unknown. So consult your doctor for more concerns.

Inform your doctor about all the underlying medical conditions. Do not stop the medicine until your doctor advises. Do not double-dose the medicine to make up for a forgotten dose. Notify your doctor if you experience any serious side effects. Your medical professional will inform you if you need any dose adjustments. Attend regular follow-up appointments with your doctor to monitor your response to the medication and any potential side effects. Contact your doctor for more information. 

1. KD Tripathi, Essentials of Medical Pharmacology, Androgens and drugs for erectile dysfunction, 7th edition, 2013, 303-304.
2. Ciplamed, [Revised on September 2019] [Accessed on 26th June 2023] https://ciplamed-library.com/content/endobloc-t-kit

The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.