This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Amlodipine+Chlorthalidone is a combination medication that contains two active ingredients, Amlodipine and Chlorthalidone. This combination is primarily used to treat high blood pressure (hypertension). Amlodipine is a calcium channel blocker that helps relax and widen the blood vessels, allowing smoother blood flow and lowering blood pressure. It is commonly prescribed to treat high blood pressure and certain types of chest pain (angina). Chlorthalidone is a diuretic commonly called a "water pill." Amlodipine was first approved by the U.S. Food and Drug Administration (FDA) on July 31, 1992. Chlorthalidone, on the other hand, was first approved by the FDA on May 10, 1960.

Mechanism of Action of undefined

The amlodipine+chlorthalidone offers a synergistic therapeutic effect in the management of hypertension. Amlodipine, a calcium channel blocker, works by relaxing and widening the blood vessels, which helps to lower blood pressure. Chlorthalidone, a thiazide diuretic, increases urine production and reduces fluid volume, lowering blood pressure.

Uses of undefined

Amlodipine+Chlorthalidone medicine treats hypertension, edema (fluid retention), and angina (chest pain).

undefined Drug administaration and Dosage available

To use Amlodipine+Chlorthalidone tablets, follow your doctor's instructions precisely. Take the tablets orally with a glass of water, either with or without food. Taking the medication simultaneously daily is important to maintain a consistent routine. Do not adjust the dosage or stop taking the medication without consulting your healthcare professional.

Warnings, Precautions and Side Effects of undefined


Both amlodipine+chlorthalidone have important warnings to consider. These medications can cause allergic reactions. It can result in low blood pressure and electrolyte imbalances and may affect kidney and liver function.


Close monitoring is necessary for individuals with pre-existing heart, lung, kidney, or liver conditions. It's important to inform your healthcare provider about any medical conditions, medications, or allergies before starting or adjusting the dose of amlodipine and chlorthalidone. Additionally, these medications have potential interactions with other drugs. If you experience severe side effects or have concerns, seek medical attention and consult with your healthcare provider.

Side Effects

Amlodipine+Chlorthalidone common side effects of amlodipine and chlorthalidone may include dizziness, headache, flushing, swelling of the ankles or feet, fatigue, and increased urination. Other potential side effects that may occur less frequently include low blood pressure, electrolyte imbalances, dry mouth, muscle cramps, rash, gastrointestinal disturbances, and changes in blood sugar levels.

Word Of Advice

Before taking these medications, inform your healthcare provider about any allergies, medical conditions, or medications you currently take. Caution is advised in individuals with a history of allergic reactions, low blood pressure, electrolyte imbalances, kidney or liver disease, heart conditions, asthma, or gout. Regular monitoring of blood pressure, electrolyte levels, kidney function, and liver function may be necessary. Discuss the potential risks and benefits with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. Avoid sudden changes in posture to prevent dizziness or fainting due to low blood pressure. It's important to follow the prescribed dosage and attend regular follow-up appointments with your healthcare provider to ensure safe and effective use of these medications.

Frequently Asked Question


  1. Pfizer Ltd, U.S Drug Food and Asafety Administration, [Revised date May 2011], [Accessed Date 21st June 2023]
  2. Ki-Chul Sung et al. Efficacy and safety of the low-dose antihypertensive combination of amlodipine, telmisartan, and chlorthalidone: A randomized, double-blind, parallel, phase II trial [Published on October 2022], [Accessed Date 21st June 2023]
  3. Dr. Reddy's Laboratories (UK) Ltd, Electronic Medicine corrigendum (EMC).[Accessed on 9 May 2023], [Accessed Date 21st June 2023],


The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.