This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Amlodipine, Indapamide tablets are antihypertensive medications belonging to the calcium channel blockers and thiazide diuretics category. It was approved by the U.S. Food And Drug Administration to treat hypertension.

Mechanism of Action of undefined

Amlodipine blocks calcium entry into the smooth muscle cells of blood vessels and the heart. This action leads to the relaxation and widening of blood vessels, reducing peripheral resistance and improving blood flow. Indapamide is a diuretic that removes excess amounts of water and certain electrolytes from the body by increasing urine production. Together it not only relaxes blood vessels and improves blood flow but also helps to eliminate excess fluid from the body, thereby reducing the volume of circulating blood and further aiding in blood pressure control.

Uses of undefined

Amlodipine, Indapamide has been developed to treat hypertension. It is a chronic condition characterized by persistently high blood pressure levels. If the condition is left untreated or uncontrolled, it can increase the chance of cardiovascular problems, including heart attacks and strokes. This tablet is often prescribed when a single medication alone is ineffective in controlling blood pressure.

undefined Drug administaration and Dosage available

It is an orally available prescription drug. Your doctor will decide the duration and dose of the drug based on the disease condition and other factors. Always take an Amlodipine, Indapamide tablet as prescribed by your doctor. Take the tablet with or without food. Do not open, break, chew, or crush the tablet. Swallow the whole tablet with water.

Warnings, Precautions and Side Effects of undefined


Amlodipine, Indapamide can affect uric acid levels in the body. It can increase uric acid levels, a risk factor for gout(a form of arthritis due to the excess deposition of uric acid crystals, especially in the joints, leading to swelling, pain, and inflammation). If you have a medical history of gout or are more likely to develop gout, discussing this with your doctor before taking this drug is necessary. They may suggest alternative medications and adjust the dosage to minimize the impact on uric acid levels. This medicine should not be used in patients with known hypersensitivity or allergic reactions to its components. Some individuals may experience increased sensitivity to sunlight (photosensitivity) while taking this drug. It is highly suggested to wear protective clothing and sunscreen when exposed to sunlight.


You must inform your physician about any liver or kidney problems you have. Individuals with impaired kidney function may require dose adjustments or alternative medications. Your physician will monitor your kidney function, electrolyte, blood sugar, and blood pressure regularly to ensure this tablet works properly. Notify your physician if you are pregnant, breastfeeding, or planning to have a baby. Amlodipine, Indapamide may sometimes cause fluid accumulation in the vascular part of the eye or an increase in eye pressure. If you experience decreased vision, eye pain, or any other eye-related symptoms, seek medical attention immediately, as these can result in permanent vision loss if left untreated. Do not consume grapefruit or grapefruit juice, as this may increase the medicine level in the blood.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Amlodipine, Indapamide are low potassium in the blood, palpitations, nausea, constipation, ankle swelling, tiredness, headache and muscle cramps.

Word Of Advice

Drinking enough water while taking Amlodipine, Indapamide is highly advised to overcome muscle cramps. Tiredness can occur if you have low blood pressure. Hence avoid driving or using staircases. Along with medication, your doctor may advise lifestyle modifications to manage your high blood pressure effectively. These may include adopting a healthy diet, regular exercise, limiting alcohol consumption, quitting smoking, and managing stress.

Frequently Asked Question


  1. Zentiva Pharma UK Limited, Patient information leaflet, Indapamide Film-coated Tablets - medicines (EMC). [Revised on Feb 2023], Available at: (Accessed 07 June 2023).
  2. Dr. Reddy's Laboratories (UK) Ltd, Patient information leaflet, Amlodipine- medicines (EMC). [Revised on July 2022], Available at: (Accessed 07 June 2023).
  3. Amlodipine- food and drug administration (FDA). [Revised on May 2011], Available at:,2.5%20mg%20to%205%20mg%20once%20daily.%20%282.2%29 (Accessed 07 June 2023).
  4. Package leaflet: Information for the user - Indapamide and Amlodipine. Available at: (Accessed 07 June 2023).
  5. KD Tripathi, Essentials of Medical Pharmacology, Antihypertensive drugs, 7th edition, 2013, 559.


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.