This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Ampicillin and Sulbactam is a combination antibiotic medication that contains two active ingredients, ampicillin and Sulbactam. It has been used for many years and has well-established safety profiles. They have been extensively studied and are considered safe and effective when prescribed. It is used in the treatment of various bacterial infections. Ampicillin is a penicillin-type antibiotic that works by inhibiting the growth of bacteria. It is effective against both Gram-positive and Gram-negative organisms. Sulbactam is a beta-lactamase inhibitor. Beta-lactamases are enzymes some bacteria produce that can break down certain antibiotics, including penicillins. Combining Sulbactam with ampicillin makes the medication more effective against bacteria that produce beta-lactamases. It received initial FDA approval for use in the United States on October 29, 1986.
Mechanism of Action of undefined
Ampicillin is a penicillin-type antibiotic that belongs to the beta-lactam class. It inhibits the synthesis of bacterial cell walls. Bacterial cell walls are essential for their survival and protection, and without a functional cell wall, bacteria cannot maintain their structure and integrity. Ampicillin interferes with the enzymes involved in synthesizing the bacterial cell wall, leading to its weakening and eventual lysis (breakdown). Sulbactam is a beta-lactamase inhibitor. Beta-lactamase is an enzyme certain bacteria produce to break down and inactivate beta-lactam antibiotics, including penicillins. Combining sulbactam with ampicillin makes the medication effective against bacteria that produce beta-lactamases. Sulbactam inhibits the action of these enzymes, preventing them from degrading ampicillin. This allows ampicillin to remain active and exert its antibacterial effect.
Uses of undefined
The combination of ampicillin and sulbactam is often used to treat various infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, and gynecological infections. It is also sometimes used as empiric therapy for suspected mixed infections or when the specific bacteria causing the infection are unknown.
undefined Drug administaration and Dosage available
Ampicillin and Sulbactam is typically administered by a healthcare professional. It is usually given intravenously (IV) as an infusion or injection. The healthcare provider will determine the dosage and duration of treatment based on the specific infection and individual factors.
Warnings, Precautions and Side Effects of undefined
Ampicillin and sulbactam carry the following warnings: potential for serious allergic reactions, risk of diarrhea and Clostridium difficile infection, the possibility of superinfections, caution in individuals with impaired kidney or liver function, potential interactions with other medications, risk of antibiotic resistance, increased risk of allergic reactions in individuals with asthma or allergic disorders, and rare central nervous system effects.
Discussing these warnings with your healthcare provider to ensure these medications' safe and appropriate use is essential. When using Ampicillin and Sulbactam, it is important to adhere to the prescribed dosage and follow the instructions provided by your healthcare provider. Before starting treatment, inform your healthcare provider about any medical conditions, allergies, or medications you are taking.
Regular monitoring of liver function and kidney function is advised. If you experience symptoms of a hypersensitivity reaction, such as fever, rash, or respiratory symptoms, discontinue the medication and seek immediate medical attention. Avoid alcohol and be cautious when driving or operating machinery, as these medications may cause dizziness or drowsiness. Consult your healthcare provider before changing your treatment regimen or starting new medications.
Common side effects of ampicillin and sulbactam may include nausea, vomiting, diarrhea, stomach upset, and headache. Serious side effects, although rare, can include severe allergic reactions, such as rash, itching, swelling, or difficulty breathing. Other serious side effects may include severe diarrhea, abdominal pain, or signs of a secondary infection. If any severe or persistent side effects occur, it is important to seek immediate medical attention.
Word Of Advice
Inform your healthcare provider about any existing medical conditions, such as kidney or liver problems, asthma, or allergic disorders, as dosage adjustments or additional monitoring may be necessary. Use the medication only as prescribed by a healthcare professional and complete the full course of treatment to minimize the risk of antibiotic resistance. Exercise caution during pregnancy or while breastfeeding, and thoroughly discuss the potential advantages and disadvantages with your healthcare provider. Like any other antibiotic, adhering to the instructions for taking ampicillin and sulbactam is crucial. Even if symptoms improve, completing the entire treatment course is essential to ensure the complete eradication of the infection and minimize the risk of developing antibiotic resistance.
Frequently Asked Question
- Pfizer Pvt Ltd, U.S FDA (Food and Drug Safety Administration), [last Revised Date April 2007], [Accessed on 29 May 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050608s029lbl.pdf
- Chemidex Pharma Ltd, Electronic Medicines Compendium (EMC), [Last Revised Date Sep 2021], Accessed on 29 May 2023], https://www.medicines.org.uk/emc/product/12892/pil
- The Merck Manual, "Antibiotics for Bacterial Infections," 19th Edition, 2018, 1072-1073
The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.