Apremilast was initially approved by the United States Food and Drug Administration (FDA) on 21st march 21, 2014

Apremilast treats moderate to severe plaque psoriasis, a chronic autoimmune skin condition characterized by red, itchy, and scaly patches. It is also indicated for the management of active psoriatic arthritis.

Apremilast is administered orally in the form of tablets. It is taken orally with or without food, as directed by a healthcare professional. The recommended starting dosage and any necessary dose adjustments are determined based on the specific condition being treated and the patient's response to the medication. 

Common side effects 0f Apremilast may include gastrointestinal disturbances such as diarrhea, nausea, vomiting, headache, upper respiratory tract infections, and fatigue. Some patients may also experience weight loss, decreased appetite, and back pain. More severe side effects can include depression, mood changes, and suicidal thoughts. Additionally, allergic reactions like rash and swelling may occur.

Some patients taking Apremilast have reported experiencing depression, suicidal thoughts, or changes in mood. It can cause gastrointestinal disturbances such as diarrhea, nausea, and vomiting. This medication may lead to weight loss.

It is essential to monitor for any signs of mood changes and promptly report them to a healthcare provider. Patients should be cautious and report any severe or persistent gastrointestinal symptoms to their healthcare provider. Patients should monitor their weight regularly, and significant or unexplained weight loss should be reported to a healthcare provider.

Be cautious if you have a history of depression or mood disorders before taking Apremilast. Report any changes in mood or behavior to your healthcare provider. Watch for gastrointestinal issues like diarrhea or nausea, and stay hydrated. Inform your doctor if you experience severe or persistent symptoms. Keep an eye on your weight while taking Apremilast, as it may lead to weight loss. Report any significant or unexplained weight changes to your healthcare provider. Be vigilant for signs of infection, such as fever or persistent cough, and promptly report any concerns to your doctor. Avoid live vaccinations while on this medication, which may affect your immune response. Consult your healthcare provider before receiving any vaccines. Use it with caution if you have a history of liver or kidney problems, and follow your doctor's instructions for regular monitoring. See medical attention immediately if you notice any signs of allergic reactions, such as rash or swelling. Stick to the prescribed dosage. Consult your healthcare provider before taking it. Be aware of any potential side effects and communicate any concerns promptly.

1. Amgen Ltd, Electronic medicines compendium (EMC), [Revised on30 Jun 2021] [Accessed on 19th Oct 2023], https://www.medicines.org.uk/emc/product/3648/smpc#gref
2. Amgen Inc, US Food and Drug Administration, [Revised on Dec 2021 ] [Accessed on 19th 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/205437s011lbl.pdf

The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.