This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
The U.S. FDA-approved Aprepitant to prevent nausea and vomiting due to chemotherapy on 26th March 2003.
Mechanism of Action of undefined
Aprepitant capsule blocks the action of a natural substance called neurokinin in the brain that causes nausea and vomiting. This medicine reduces the severity of chemotherapy-induced nausea and vomiting.
Uses of undefined
Aprepitant is used to prevent nausea and vomiting due to chemotherapy in adults and children of twelve years and older.
undefined Drug administaration and Dosage available
Swallow the Aprepitant capsule as a whole with water. Do not crush or chew the capsules. These capsules can be taken with or without food. Do not take more than recommended. If this medicine is prescribed, your physician will choose the dosage based on your medical condition because it differs for each person. Only stop taking Aprepitant if your doctor advises you to stop.
Warnings, Precautions and Side Effects of undefined
Before taking this capsule, inform your doctor if you have liver disorders because the liver is crucial in breaking down medicine. The doctor may therefore have to monitor the condition of the liver. Certain medications, such as Pimpzide, Terfenadine, and Cisapride may interact with Aprepitant and reduce effectiveness by causing undesirable side effects. This medicine is not recommended to use with children under the age of 12.
Before starting the treatment, your doctor may monitor your liver function. Inform your physician if you experience allergic reactions to Aprepitant. Before starting the treatment, inform your doctor if you are pregnant or think you may be pregnant or are planning to have a baby because your physician shall prescribe Aprepitant only if it is essential. Consult your doctor for more information.
The most common side effects of Aprepitant are tiredness, increased liver enzyme, indigestion, constipation, loss of appetite, hiccups, and headaches.
Serious side effects while taking Aprepitant is allergic reactions such as rash, itching, difficulty breathing, or swallowing.
Word Of Advice
Store at room temperature 20°C to 25°C. Keep out of sight and reach of children. Store in the original package in order to protect it from moisture. Contact your doctor for more concerns. Do not double the dose if missed the turn. Contact your doctor immediately if you double dose.
Frequently Asked Question
- KD Tripathi, Essentials of Medical Pharmacology, Antiemetic, Prokinetic and Digestant Drugs, 7th edition, 2013, 669-670.
- Goodman & Gilman’s, The Pharmacological Basics of Therapeutics, Treatment of disorders of bowel motility and water flux, 12th edition, 2011, 1345.
- Ethypharm, Electronic Medicines Compendium (EMC), [Revised on Oct 2022]; [Accessed on 19th April 2023], https://www.medicines.org.uk/emc/files/pil.14650.pdf
- Merck Sharp & Dohme Corp, US Food and Drug Administration, [Revised date April 2015], [Accessed on 19th April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021549s025lbl.pdf
The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.