This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
The U.S. FDA approved Asciminib on October 10, 2021, as an anticancer medication to treat Philadelphia chromosome-positive chronic myeloid leukaemia (Ph+ CML) in the chronic phase (CP).
Mechanism of Action of undefined
Asciminib is an allosteric inhibitor of the BCR-ABL1 tyrosine kinase, a fusion protein resulting from the Philadelphia chromosome translocation in chronic myeloid leukaemia (CML). It binds specifically to the myristoyl pocket of the ABL1 domain within the BCR-ABL1 protein, inducing a conformational change that locks the protein in an inactive state and inhibits its oncogenic activity.
Uses of undefined
Asciminib is used to treat a certain type of chronic myeloid leukaemia (CML; a type of cancer of the white blood cells) in a chronic phase (CP) who have been previously treated with two or more tyrosine kinase inhibitors.
undefined Drug administaration and Dosage available
Take Asciminib exactly as your healthcare provider prescribes. Do not change your dose or stop taking Asciminib unless your doctor tells you to. Take Asciminb without food. You should avoid eating for at least 2 hours before and 1 hour after taking Asciminib. Do not break, crush or chew the tablet.
Warnings, Precautions and Side Effects of undefined
Warnings
Asciminib may cause serious allergic reactions. Check with your doctor right away if you have dizziness, chest tightness, fast heartbeat, cough, skin rashes, fever, fainting, abdominal pain, diarrhoea, swelling of the face, lips, or tongue, or difficulty breathing or swallowing.
Precautions
Consult your doctor before using Asciminib if you are pregnant or plan to have a baby. Asciminib can harm the unborn baby. If you're a woman who can get pregnant, your doctor may do tests to make sure you are not pregnant before starting this medicine. Use an effective form of birth control during treatment and for at least 1 week after the last dose to avoid indications.
Some women who use Asciminib have become infertile. Talk with your doctor if you plan to have children.
Side Effects
The side effects known to occur commonly during the treatment with Asciminib are
Common side effects
- Upper respiratory tract infection
- Headache and nausea
- Tiredness
- Rashes
- Muscle, bone or joint pain
- Diarrhea
Rare side effects
- Trouble breathing or swallowing
- Swelling of the face, lips, or tongue
- Fever
- Skin rash or flushing of your skin
- Fast heartbeat
- Feeling dizzy or faint
Word Of Advice
Store it at room temperature in the container it is packed in and close it tightly. Keep it out of sight and reach of children. If you are taking any laboratory tests, tell your doctor that you are taking Asciminib. Asciminib may increase your blood pressure. You may be asked to monitor your blood pressure frequently while taking this medication. Please let your doctor know if you notice any changes in your blood pressure.
Frequently Asked Question
Disclaimer
The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.
