This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Avanafil is a class of impotence agents that belongs to the category of medicines known as phosphodiesterase type 5 (PDE5) inhibitors. It was approved by the U.S. Food and Drug Administration on April 27, 2012 for treating erectile dysfunction.

Mechanism of Action of undefined

Avanafil works by inhibiting the action of the enzyme PDE5, which is responsible for the degradation of cyclic guanosine monophosphate (cGMP). By blocking PDE5, Avanafil helps to increase the levels of cGMP, which promotes relaxation of the smooth muscles in the penile region and improves blood flow, leading to an erection.

Uses of undefined

Avanafil has been developed to  treat erectile dysfunction (ED), also known as impotence, which refers to the inability to maintain an erection sufficient for satisfactory sexual performance.

undefined Drug administaration and Dosage available

It is an orally available prescription drug. Your doctor will decide the duration and dose of the drug based on the disease condition and other factors. Always take an Avanafil Tablet 30 minutes before sexual activity. Do not open, break, chew, or crush the tablet. Swallow the whole tablet with water.

Warnings, Precautions and Side Effects of undefined


This medicine should not be consumed if you have any known allergy to the drug or its components. This drug is only intended for adult men, and children or women should not use it. Avanafil, like other PDE5 inhibitors, has been associated with priapism. If you feel an erection lasting longer than four hours, seek immediate medical emergency. Untreated priapism can damage the penis and cause permanent erectile dysfunction. Before taking this tablet, inform your physician if you have any serious bleeding disorders or are currently being treated for an ulcer. This drug may increase the chance of bleeding disorder and peptic ulcer (stomach or duodenum).


This medicine can cause a sudden decrease in blood pressure. Inform your doctor if you have a history of heart disorders, low blood pressure, chest pain, or other cardiovascular conditions. In rare cases, sudden vision or hearing loss has been reported using Avanafil. If you experience sudden vision or hearing changes, discontinue the drug immediately. Consumption of grapefruit juice or alcohol while taking this tablet may increase the risk of side effects. It is advisable to limit or avoid the use of alcohol and grapefruit juice while using this medication.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Avanafil are flushing (sense of warmth in the ears, neck, and face), headache, back pain, nasopharyngitis (inflammation of the nasal passages) and nasal congestion (stuffy nose). Some serious side effects also include priapism, loss of vision, loss of hearing and blurred vision.

Word Of Advice

Avanafil alone does not cause spontaneous erections. Sexual stimulation is required for an erection. Engage in the usual sexual foreplay and stimulation as desired. This drug is taken on an as-needed basis before sexual activity. It is not intended for daily use. Do not exceed the recommended dosage frequency or take more than one dose within a day, as it can increase the chance of serious side effects.

Frequently Asked Question


  1. Menarini international operations luxembourg s.a, Patient information leaflet Avanafil Tablets (EMC). [Revised on Jan 2023], Available at: (Accessed 08 Jun 2023).
  2. Avanafil - food and drug administration (FDA). [Revised on Aug 2018], Available at: (Accessed 08 Jun 2023).
  3. Menarini international operations luxembourg s.a European Medicines Agency (EMA),. Available at: [Accessed 08 Jun 2023]
  4. Bertram.G.Katzung, Basic and Clinical Pharmacology, Drugs used in the treatment of Erectile Dysfunction, 14th edition, 2017, 200.


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.