This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Bedaquiline belongs to the therapeutic class of antimycobacterial agents. It was approved by the FDA in 2012 for the treatment of multidrug-resistant tuberculosis (MDR-TB).
Mechanism of Action of undefined
Bedaquiline works by inhibiting the mycobacterial ATP synthase enzyme, which is essential for the energy production in tuberculosis bacteria. This action reduces bacterial replication, aiding in the control of tuberculosis infection.
Uses of undefined
Bedaquiline is used as part of combination therapy to treat multidrug-resistant pulmonary tuberculosis in adults when other alternatives are not sufficient.
undefined Drug administaration and Dosage available
Bedaquiline is administered orally, usually in combination with other TB medications. The dose and duration depend on the patient's condition and their response to treatment. It is essential to follow the prescribed regimen closely.
Warnings, Precautions and Side Effects of undefined
Warnings
Bedaquiline should not be used as monotherapy due to the risk of resistance. QT prolongation has been observed, and its use requires ECG monitoring.
Precautions
Bedaquiline should be used cautiously by patients with a history of heart conditions or those taking other drugs that affect heart rhythm.
Side Effects
Common side effects include nausea, joint pain, headache, and dizziness. Serious effects like QT prolongation and liver toxicity can occur and need monitoring.
Word Of Advice
Take Bedaquiline with food to enhance absorption. It is crucial to complete the entire course of therapy and not miss doses, as this can lead to treatment failure and resistance. Avoid alcohol and monitor liver function during treatment. Always consult your doctor for any concerns.
Frequently Asked Question
References
- https://pubchem.ncbi.nlm.nih.gov/compound/Bedaquiline
- https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/bedaquiline
- KD Tripathi, Essentials of Medical Pharmacology, Antiemetic, Prokinetic and Digestant Drugs, 7th edition, 2013, 669-670.
Disclaimer
The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.
