This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval


Mechanism of Action of undefined

The benfotiamine + methylcobalamin + alpha lipoic acid + folic acid supplements enhance nerve function and reduce neuropathic pain. Benfotiamine and methylcobalamin repair damaged nerve fibers, while alpha-lipoic acid protects nerve cells from oxidative damage. Folic acid prevents DNA and nerve cell damage. These supplements also offer potential benefits, such as improved heart health, mood, and cognitive function. While promising, more research is needed to confirm their full range of health benefits.

Uses of undefined

Benfotiamine + methylcobalamin + alpha lipoic acid + folic acid combination is approved for medical use as a nutritional supplement in India to treat nutritional deficiency and to manage diabetic neuropathy.

undefined Drug administaration and Dosage available

Benfotiamine + methylcobalamin + alpha lipoic acid + folic acid offer diverse health benefits. They are used to treat nutritional deficiencies and nerve disorders. Benfotiamine, a fat-soluble vitamin B1, is vital for nerve health, especially in conditions like diabetic neuropathy. Methylcobalamin, an active B12 form, is crucial in managing anemia and nerve-related issues. Alpha-lipoic acid acts as an antioxidant and is beneficial for diabetic neuropathy and metabolic syndrome. Folic acid, a synthetic form of vitamin B9, helps prevent neural tube defects during pregnancy and aids in treating anemia caused by folate deficiency.

Warnings, Precautions and Side Effects of undefined


Benfotiamine + methylcobalamin + alpha lipoic acid + folic acid supplement is generally safe to consume and is not associated with significant side effects. However, some people may experience side effects such as nausea, vomiting, diarrhea, stomach upset, and headache. If you experience any side effects, talk to your doctor.


This combination is not recommended for people who are allergic to any of its active ingredients. Inform your doctor if you have kidney disease, liver disease, or kidney stones before taking these supplements. Always give a detailed account of your medical history and the medications before taking this supplement.

Side Effects

Benfotiamine + methylcobalamin + alpha lipoic acid + folic acid combination is available in tablet form for oral intake. Your physician will decide the dosage of this injection based on the severity of your disease and other factors.

Word Of Advice

It is advisable to consult a healthcare professional before use, especially for those who are pregnant, breastfeeding, or have underlying health conditions such as liver disease, lung disease, heart disease, or kidney disease. Additionally, individuals consuming alcohol should seek medical advice before taking these supplements to ensure their safety and well-being.

When taking benfotiamine + methylcobalamin + alpha-lipoic acid + folic acid combination, it is advisable to consume it with food to prevent stomach upset. It's important to stay within the recommended dosage specified by your healthcare provider. Before starting this supplement, inform your doctor about all other medications and supplements you are currently taking to ensure compatibility. If you encounter any side effects, promptly consult your doctor for further guidance and assistance.

Frequently Asked Question


  1. Wörwag Pharma, Manufacturer, [Revised on Oct 2021] [Accessed on Oct 2023]
  2. Viswanathan M, et al., Folic Acid Supplementation to Prevent Neural Tube Defects: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force; JAMA. [Revised on Aug 2023] [Accessed on Oct 2023]
  3. Miao Y, et al., The effect of B-vitamins on the prevention and treatment of cardiovascular diseases: a systematic review and meta-analysis; Nutr Rev; [Revised on Oct 2023] [Accessed on Oct 2023]
  4. Muley A, et al., Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis; BMJ Open; [Revised on Aug 2022] [Accessed on Oct 2023]
  5. Temova Rakuša Ž, et al., Vitamin B12 in Foods, Food Supplements, and Medicines-A Review of Its Role and Properties with a Focus on Its Stability; Molecules ; [Revised on Dec 2022] [Accessed on Oct 2023]
  6. Nguyen H, et al., Alpha-Lipoic Acid; Treasure Island (FL): StatPearls Publishing; [Revised 2022 Sep 26] [Accessed on Oct 2023]


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