This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Benidipine, a dihydropyridine calcium channel blocker, was developed to treat cardiovascular conditions like hypertension and angina. Initially approved in Japan in 1991, Benidipine has since gained popularity for its ability to effectively reduce blood pressure and lessen the heart’s workload.
Clinical trials demonstrated its effectiveness in reducing blood pressure and managing angina symptoms by promoting vasodilation and improving heart function. These trials highlighted Benidipine’s unique ability to block multiple types of calcium channels (L-type, T-type, and N-type), which was associated with improved safety and efficacy compared to other calcium channel blockers.
Mechanism of Action of undefined
Benidipine acts by blocking L-type, T-type, and N-type calcium channels within the heart and blood vessels. By preventing calcium influx, it causes relaxation of vascular smooth muscles, resulting in vasodilation and lowered blood pressure. Additionally, Benidipine decreases the oxygen demand of the heart, making it effective for managing angina.
Uses of undefined
Benidipine is primarily indicated for:
- Hypertension
- Angina Pectoris
undefined Drug administaration and Dosage available
Benidipine is available in oral tablet form. The typical starting dose for adults is 2-4 mg once daily. The dosage can be adjusted based on a person’s response and tolerance, but it should be taken as prescribed by a cardiologist to achieve optimal results.
Warnings, Precautions and Side Effects of undefined
Warnings
- Pregnancy and Breastfeeding: Benidipine should be used during pregnancy or breastfeeding only if prescribed by a doctor.
- Liver and Kidney Impairment: Patients with liver or kidney dysfunction should use Benidipine cautiously as it may require dosage adjustment.
- Hypotension: Benidipine may cause a significant drop in blood pressure, especially in patients taking other antihypertensives.
Precautions
- Refrain from consuming grapefruit or grapefruit juice, as it can elevate the blood concentration of Benidipine, leading to enhanced side effects.
- Alcohol intake should be minimised, as it can exacerbate the blood pressure-lowering effects.
- Elderly patients should use Benidipine with caution, as they may be more sensitive to its effects.
Side Effects
Common side effects of Benidipine include:
- Dizziness or lightheadedness
- Headache
- Swelling in the ankles or legs
- Flushing Less common but serious side effects include significant hypotension, fast or irregular heartbeat, and symptoms of allergic reaction like rash or difficulty breathing. Always consult a doctor if any of these symptoms occur.
Word Of Advice
Take Benidipine at the same time each day to maintain stable blood levels for effective results. Regularly monitor your blood pressure and heart rate to confirm the medication is effective and to catch any side effects early. Supporting Benidipine therapy with a healthy diet, regular exercise, and stress management can further benefit cardiovascular health. Always consult your healthcare provider before combining Benidipine with other medications to prevent potential interactions.
Frequently Asked Question
References
Disclaimer
The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to determine if you are eligible to receive this treatment.
