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Written By
Sakshi Anil More
B. Pharm
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:30 AM (IST)
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Quick Summary
BENRALIZUMAB
Last updated on 31 Mar 2026 | 09:30 AM (IST)
BENRALIZUMAB
Background and Date of approval BENRALIZUMAB
Benralizumab is an antiasthmatic drug developed by the U.S. Food And Drug Administration and initially approved in Nov 2017 for treating severe eosinophilic asthma.
Uses of BENRALIZUMAB
Benralizumab is used to treat severe eosinophilic asthma, a subtype of asthma caused by high levels of eosinophils in the blood and airways. It is also approved for treating eosinophilic granulomatosis with polyangiitis (EGPA), a rare autoimmune disease affecting blood vessels and organs.
How is BENRALIZUMAB administered?
Benralizumab will be given by injection under the skin (subcutaneous). Your doctor, nurse, or other healthcare professional will show you how to inject the medicine. Do not try to administer the medicine if you are well-trained. Your physician will decide the injection dose based on your disease condition and severity.
Side Effects of BENRALIZUMAB
The side effects known to occur commonly during the treatment with Benralizumab are headache, sore throat, rashes, fever, injection site reactions, and muscle pain. Some serious side effects include hypersensitivity reactions.
Warnings
Before using Benralizumab, it's essential to talk to your doctor if you have a history of allergic reactions to certain injections or medicines, have a parasitic infection, and live in an area where parasitic infections are common because this drug may weaken your ability to fight certain types of parasitic infections. If your asthma remains uncontrolled or worsens during treatment, immediately discuss this with your physician. This medicine is not intended for the treatment of sudden asthma attacks. It should not be used as a rescue medication in such situations.
Precautions
Do not use Benralizumab unless your doctor advises. Notify your physician if you are pregnant or planning to have a baby; think you may be pregnant so that your doctor may decide to give you this medicine if the expected benefits outweigh any potential risks. It is unknown whether this drug passes into breast milk and is safe to administer during breastfeeding. Inform your physician if you are a nursing mother. This medicine is not recommended for use in children under 18 because the safety and benefits of this medication have not been established in this age group. Parents and caregivers should consult physicians for appropriate asthma management and treatment options for children and adults.
Word of Advice
Before taking Benralizumab, your doctor will likely assess your medical history and perform any necessary tests to determine if it is a suitable treatment for your specific condition. They will also provide you with instructions on how to take the medication properly and monitor your progress during treatment.
Frequently Asked Questions
Q1.
How is Benralizumab administered?
Benralizumab is administered as a subcutaneous injection (under the skin). The frequency and dosing may vary depending on the specific treatment regimen prescribed by a healthcare provider. It is usually given once every 4 to 8 weeks.
Q2.
Is Benralizumab a cure for asthma?
Benralizumab is not a cure for asthma. It is a medication designed to help manage and control severe eosinophilic asthma by reducing airway inflammation and symptoms. While it can significantly improve the quality of life for many people with severe asthma, it does not eliminate the underlying condition, and treatment may need to be continued as long as the condition persists.
Q3.
Can Benralizumab be used in children?
Benralizumab is approved for use in adolescents aged 12 years and older with severe eosinophilic asthma. Its safety and efficacy in younger children have not been established, so it is generally not prescribed for those below the approved age range.
Q4.
What formulations are available for Benralizumab?
Benralizumab is available in injection form. The specific formulation and dosing will depend on the individual's condition and the healthcare provider's recommendation.
Q5.
Who should not take Benralizumab?
Benralizumab may not be suitable for everyone. Individuals with known hypersensitivity or allergy to it or its components should not use it. It is important to inform your physician of any other medical conditions or medications you are taking before starting the treatment.
Q6.
Who should not take Benralizumab?
Benralizumab may not be suitable for everyone. Individuals with known hypersensitivity or allergy to it or its components should not use it. It is important to inform your physician of any other medical conditions or medications you are taking before starting the treatment.
References
- AstraZeneca, Electronic Medicines Compendium (EMC), [Revised on Dec 2022] [Accessed on 1st Sep 2023], https://www.medicines.org.uk/emc/files/pil.8918.pdf
- AstraZeneca, [Revised on 20th Aug 2021] [Accessed on 1st Sep 2023], https://www.astrazeneca.ca/content/dam/az-ca/downloads/productinformation/fasenra-product%20monograph-en.pdf
- Corrado Pelaia et al., Benralizumab: From the Basic Mechanism of Action to the Potential Use in the Biological Therapy of Severe Eosinophilic Asthma, BioMed Research International, 2018, [Accessed on 1st Sep 2023], https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971345/pdf/BMRI2018-4839230.pdf
Disclaimer
The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.
