This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

The U.S. FDA approved Benzydamine, Chlorhexidine gluconate spray, as a non-steroidal anti-inflammatory drug (NSAID) to treat pain and inflammation in the mouth on 1st January 2013. 

Mechanism of Action of undefined

Benzydamine, Chlorhexidine gluconate spray, is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the production of prostaglandins. The role of prostaglandins is to increase the blood supply to the affected area resulting in pain and swelling. Hence inhibiting the prostaglandins helps in reducing pain and inflammations. Chlorhexidine gluconate is a disinfectant and an antiseptic agent which reduces the formation of microbes on the oral surface.

Uses of undefined

Benzydamine, Chlorhexidine gluconate spray has been developed to treat pain and inflammation, including sore throat, tongue, or gums, mouth ulcerspost-dental surgery pain, discomfort caused by dentures, swelling, redness, and a feeling of heat in the mouth or throat.  

undefined Drug administaration and Dosage available

Spray directly into the mouth or throat surfaces, ulcers, or other sore areas. Spray as often as prescribed by your physician. Be careful that the Benzydamine, Chlorhexidine gluconate, and spray are not splashed in your eyes while using it. In case of accidental contact, wash your eyes immediately with cold water.

Warnings, Precautions and Side Effects of undefined


Talk to your physician if you have a history of asthma before taking Benzydamine, Chlorhexidine gluconate spray. Notify your doctor if you are allergic to Acetylsalicylic acid or other non-steroidal anti-inflammatory (NSAID) drugs. Notify your doctor if you are pregnant or planning to get pregnant before taking Benzydamine, Chlorhexidine gluconate spray. Consult whether this spray is safe to use or not in such conditions.


Report to your physician immediately if you experience any symptoms, such as an allergic reaction or tightening of the throat or chest after using the spray. If you accidentally swallow it or splash the spray in your eyes, contact your doctor immediately for advice. Do not use the spray more than four times at the same time. 

Side Effects

The most common side effect likely to occur while you are on the treatment with Benzydamine, Chlorhexidine gluconate spray is chest pain or tightness, difficulty, or shortness of breath. 

Some serious effects likely to occur while you are using Benzydamine, Chlorhexidine gluconate spray are allergic reactions (anaphylactic shock), severe skin itching, lumps on the skin, and facial swelling, lips, tongue, or throat.

Word Of Advice

Keep Benzydamine, Chlorhexidine gluconate spray out of sight and reach of children. Do not store above 25ºC. Consult your doctor if you experience any symptoms like; chest tightness, shortness, or difficulty breathing while taking Benzydamine, Chlorhexidine gluconate spray.  

Frequently Asked Question


  1. Focus  pharmaceuticals limited, Electronic medicines compendium (emc), [Revised on May 2021] [ Accessed on 02 May 2023],
  2. G Roopashri et al; Efficacy of benzydamine hydrochloride, chlorhexidine, and povidone iodine in the treatment of oral mucositis among patients undergoing radiotherapy in head and neck malignancies: A drug trail; Contemporary Clinical Dentistry; Published on March 2011; Accessed on 20/08/2021;


The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.