This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Bisoprolol is an antihypertensive drug that belongs to the category of medicines known as beta1-selective adrenoceptor-blocking agents. It was approved by the U.S. FDA in 1986 to treat hypertension, angina pectoris, and chronic heart failure.
Perindopril is an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure and other heart-related conditions. It was approved by the U.S. FDA in 1993.
Mechanism of Action of undefined
Bisoprolol is a beta1-selective adrenoceptor-blocking agent that affects the body's response to certain nerve impulses, especially in the heart. It works by decreasing the heart rate and making it easier for the heart to pump blood throughout the body. As a result, it reduces blood pressure and the risk of having a stroke, heart attack, or other heart problems.
Perindopril inhibits the angiotensin-converting enzyme, leading to decreased production of angiotensin II. This results in vasodilation and reduced blood pressure, easing the workload on the heart.
Uses of undefined
- Bisoprolol has been approved to treat:
- Hypertension (high blood pressure)
- Angina pectoris (chest pain)
- Chronic heart failure
- Perindopril is used to treat:
- Hypertension
- Heart failure
- To reduce the risk of cardiac events in patients with stable coronary artery disease
undefined Drug administaration and Dosage available
- Bisoprolol: The recommended initial dose is 5 mg per day. The usual dosage is 10 mg once daily, with a maximum daily dose of 20 mg. It should be taken in the morning with food. Swallow the tablets whole with water. Do not crush, chew, or break them.
- Perindopril: The initial recommended dose is 4 mg once daily, which may be increased to 8 mg once daily based on patient response. It should be taken in the morning before meals.
Warnings, Precautions and Side Effects of undefined
Warnings
- Bisoprolol: Contact your physician immediately if you experience allergies to Bisoprolol and its ingredients.
Inform your physician if you have kidney or liver conditions.
Before taking this medication, let your medical professional know if you have a medical history of severe asthma or chronic lung disease, slow or irregular heart rate, heart failure, cardiogenic shock, metabolic acidosis, or untreated pheochromocytoma. - Perindopril: Inform your physician if you have a history of angioedema, kidney impairment, or are on diuretic therapy.
Monitor for signs of hypotension, especially after the first dose.
Precautions
- Bisoprolol: Consult your doctor before using this medication if you are pregnant or planning to have a baby.
Avoid breastfeeding your baby while on the treatment, as it is not known whether Bisoprolol passes into the breast milk and affects the baby. - Perindopril: Use caution if you are pregnant or planning to become pregnant, as ACE inhibitors can cause injury or death to the developing fetus.
Side Effects
Bisoprolol and Perindopril are commonly prescribed for heart conditions, but they may cause certain side effects. Here are some potential side effects:
- Fatigue and dizziness
- Slow heart rate (bradycardia)
- Low blood pressure (hypotension)
- Cold hands and feet
- Shortness of breath or wheezing (especially in asthma patients)
- Sleep disturbances, including nightmares
- Depression or mood changes
- Dizziness and lightheadedness
- Dry, persistent cough
- Low blood pressure
- Increased potassium levels (hyperkalemia)
- Headache and fatigue
- Nausea and digestive issues
- Swelling of the face, lips, or throat (rare but serious allergic reaction)
Word Of Advice
This combination should be avoided by pregnant or breastfeeding women, patients with severe kidney or liver disease, asthma, very low heart rate, or a history of angioedema. Always inform your doctor about your medical history before starting this medication.
Frequently Asked Question
References
Disclaimer
The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.
