This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Bupivacaine hydrochloride contains the active component Bupivacaine hydrochloride. It is a local anesthetic medication used for various medical procedures to numb a specific body area. It is commonly administered by injection near nerves to relieve pain during surgical procedures, childbirth, or other medical interventions. This anesthesia belongs to the class of drugs known as amide-type local anesthetics. It can be employed for surgical procedures, including orthopedic surgeries, cesarean sections, and dental procedures. It may also manage chronic conditions like postoperative pain or chronic pain syndromes. This medication should not be administered if there is an active infection at the intended injection site.

Mechanism of Action of undefined

The therapeutic effect of bupivacaine hydrochloride is primarily related to its function as a local anesthetic. When administered, it blocks the transmission of nerve signals in the area where it is applied, resulting in a temporary loss of sensation and pain relief. This effect allows various medical procedures to be performed with reduced or eliminated pain.

Uses of undefined

Bupivacaine Hydrochloride used in anesthesia for surgical procedures, labor, and delivery

It is also used in chronic pain management.

undefined Drug administaration and Dosage available

A healthcare provider typically gives Bupivacaine hydrochloride via injection. A healthcare provider will determine the recommended dosage based on age, weight, and specific purpose.

Warnings, Precautions and Side Effects of undefined


Bupivacaine hydrochloride carries warnings regarding its use, including the potential for cardiac effects, respiratory depression, allergic reactions, and local anesthetic systemic toxicity (LAST). LAST can manifest as symptoms like confusion, blurred vision, tremors, or cardiac arrest. central nervous system effects, impaired hepatic function, and neurologic effects. Rarely it causes methemoglobinemia and hypersensitivity reactions.


Precautions to be taken when using bupivacaine hydrochloride include careful administration to avoid intravascular injection, monitoring of cardiac function and respiratory status during and after administration, caution in patients with impaired hepatic function or pre-existing cardiac or respiratory conditions, careful consideration of dosage and concentration to minimize the risk of systemic toxicity, close observation for signs of allergic reactions or neurologic complications, adherence to pediatric dosing guidelines, awareness of potential drug interactions, and individualized assessment of the risks versus benefits in pregnant, breastfeeding, and elderly patients.

Side Effects

Bupivacaine hydrochloride's common side effects may include temporary numbness, tingling, muscle weakness at the injection site, dizziness, drowsiness, nausea, vomiting, headache, and itching. Serious side effects, although rare, may include allergic reactions (such as rash, itching, or swelling), respiratory depression (slowed breathing), cardiovascular effects (such as low blood pressure or abnormal heart rhythms), and neurologic effects (such as seizures or nerve damage).

Word Of Advice

Regarding your health and medication usage, it is important to prioritize open communication with your healthcare provider. Make sure to provide them with a comprehensive overview of your medical history, including any existing conditions, medications you are currently taking, or any allergies you may have. Elderly individuals may be more sensitive to the effects of bupivacaine hydrochloride. Age-related changes in metabolism reduce cardiac reserve, and other factors can increase the risk of adverse reactions. Close monitoring and appropriate dose adjustments may be necessary. 

This medication may interact with other medications, including certain antiarrhythmics, calcium channel blockers, and beta-blockers. These interactions can potentiate cardiac effects, increasing the risk of arrhythmias or other cardiac complications. Specific pediatric dosing guidelines should be followed, and caution should be exercised to avoid overdosing or accidental intravascular injection. Do not hesitate to contact your healthcare provider for guidance if you experience any unexpected or concerning symptoms after receiving it or other medications.

Frequently Asked Question


  1. Aspen Ltd, Electronic medicines compendium (EMC), [Revised on 26 May 2023], [Accessed on 6th June 2023],
  2. Hospira, Inc, US Food and Drug Administration, [Revised on Nov 2018],[Accessed on 6th June 2023],


The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.