This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Cefoperazone + Sulbactam is an antibiotic medication developed by the U.S. Food And Drug Administration and initially approved in the year 1981, for treating serious infections such as urinary tract infections, respiratory tract infections, intra-abdominal infections, septicemia, meningitis, skin infections, bone infections, and endometritis.

Mechanism of Action of undefined

Cefoperazone is an antibiotic that works by interfering with bacterial cell wall synthesis, leading to the destruction of the bacteria. Sulbactam, the beta-lactamase inhibitor, helps inactivate the beta-lactamase enzymes produced by certain bacteria. This prevents the breakdown of cefoperazone by these enzymes, enhancing its effectiveness against resistant bacteria.

Uses of undefined

Cefoperazone + Sulbactam this combination is effective against a wide range of bacteria and this drug is commonly used to treat serious infections such as urinary tract infections, respiratory tract infections, intra-abdominal infections, septicemia, meningitis, skin infections, bone infections, and endometritis.

undefined Drug administaration and Dosage available

This injection is available with a dose of 2gm, 3gm and 1.5gm. Do not self-administer the Cefoperazone + Sulbactam injection. Your doctor will decide the duration and dose of your treatment based on the disease severity and other factors. It will be given as an intravenous infusion, and you will be monitored carefully for unwanted side effects. 

Warnings, Precautions and Side Effects of undefined


This drug is contraindicated in individuals with known hypersensitivity or allergy to it or its component. Report your physician if you are allergic to any antibiotic group. Consumption of alcohol (including alcoholic beverages, medications containing alcohol, mouthwashes, or food preparations) during and up to the fifth day after Cefoperazone + Sulbactam administration can result in a disulfiram-like reaction. This reaction can cause flushing, sweating, headache, and an increased heart rate. It is important to avoid alcohol during this period.


Notify your doctor if you have severe or bloody stools while taking Cefoperazone + Sulbactam. Before taking this medicine, talk to your doctor if you have liver disorders, bowel diseases, or clotting disorders. This drug should be taken only if it is necessary during pregnancy. As this medicine passes poorly into the breastmilk of nursing mothers, caution should be exercised during breastfeeding. It is necessary to consult this with your physician for more advice.

Side Effects

The side effects known to occur commonly during the treatment with Cefoperazone + Sulbactam are nausea, vomiting, headache, diarrhoea, allergic reactions, anaemia, abnormal liver function and injection site reactions.

Word Of Advice

Maintaining good hand hygiene by washing your hands regularly helps to prevent the spread of infections to others. Do not skip doses or stop the medication suddenly, even if you start feeling better. Completing the full course of treatment is important to effectively treat the infection and prevent the development of antibiotic resistance.

Frequently Asked Question


  1. Pfizer Limited, [Revised on April 2020] [ Accessed on 27th June 2021],
  2. Pfizer, US Food and Drug Administration, [Revised on March 2015] [ Accessed on 27th June 2021],
  3. Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Penicillins, cephalosporins, and other beta-lactam antibiotics, 12th edition, 2011, 1499.
  4. KD Tripathi, Essentials of Medical Pharmacology, Beta-lactam antibiotics, 7th edition, 2013, 728.


The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.