This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Cefotaxime contains the active component Cefotaxime. It is a broad-spectrum antibiotic medication used to treat various bacterial infections. It belongs to the class of antibiotics known as third-generation cephalosporins. This medication works by inhibiting the growth and reproduction of bacteria, helping the immune system eliminate the infection. Cefotaxime is effective against both gram-positive and gram-negative bacteria. It covers a wide range of pathogens, including common bacteria responsible for respiratory tract infections, urinary tract infections, skin and soft tissue infections, and intra-abdominal infections. Its ability to penetrate the blood-brain barrier effectively treats central nervous system infections. This medication is generally well-tolerated by most individuals. While side effects can occur, they are typically mild and transient, with serious adverse reactions being rare. Cefotaxime received FDA approval on June 19, 1979.

Mechanism of Action of undefined

Cefotaxime inhibits bacterial growth, leading to cell death and treating various bacterial infections effectively. Its broad-spectrum activity targets both gram-positive and gram-negative bacteria. Disrupting bacterial cell wall synthesis eliminates the causative bacteria responsible for respiratory tract infections, urinary tract infections, skin and soft tissue infections, septicemia, meningitis, and intra-abdominal infections. Its therapeutic effect offers a powerful weapon against bacterial infections.

Uses of undefined

Cefotaxime is a broad-spectrum antibiotic used to treat various bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, septicemia, and as prophylaxis during certain surgical procedures.

undefined Drug administaration and Dosage available

Cefotaxime is typically administered through injection by a healthcare professional. The dosage and duration of treatment depend on the specific infection being treated, the severity of the infection, and individual patient factors such as age and overall health.

Warnings, Precautions and Side Effects of undefined


Cefotaxime carries important warnings that should be considered before use. These include the risk of severe hypersensitivity reactions, such as anaphylaxis, the potential development of Clostridioides difficile infection resulting in severe diarrhea and colitis, and the possibility of superinfection with resistant bacteria or fungi.


When using Cefotaxime, taking special caution in patients with renal impairment, a history of seizures, and during pregnancy and breastfeeding is important. Knowing these warnings and consulting a healthcare professional for appropriate guidance and monitoring during cefotaxime treatment is crucial.

Side Effects

Cefotaxime may cause various side effects, although not everyone experiences them. Common side effects include diarrhea, nausea, vomiting, skin rash, and injection site reactions. Serious but rare side effects can include severe allergic reactions like anaphylaxis, severe skin conditions such as Stevens-Johnson syndrome or toxic epidermal necrolysis, Clostridioides difficile-associated diarrhea, liver problems, blood disorders, and central nervous system effects like seizures.

Word Of Advice

Regarding your health and medication usage, it is important to prioritize open communication with your healthcare provider. Make sure to provide them with a comprehensive overview of your medical history, including any existing conditions, medications you are currently taking, or any allergies you may have. Elderly individuals may be more sensitive to the effects of Cefotaxime. Monitor if you see any infusion-related problems. Age-related changes in metabolism reduce cardiac reserve, and other factors can increase the risk of adverse reactions. Close monitoring and appropriate dose adjustments are necessary for the elderly. Individuals with liver or kidney impairment should be closely monitored during treatment. Pregnant and breastfeeding women should consult a doctor before taking it. Lastly, use caution in pediatric patients and discuss the potential risks and benefits with a healthcare professional.

Frequently Asked Question


  1. Wockhardt UK Ltd, Electronic medicines compendium (EMC), [Revised on 01 Nov 2022], [Accessed on 7th June 2023],
  2. Baxter Healthcare Corporation, US Food and Drug Administration, [Revised on September 2011],[Accessed on 7th June 2023],,050596s037lbl.pdf


The drug information on this page is different from medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.