This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Ceftazidime + Avibactam is an antibiotic medication developed by the U.S. Food And Drug Administration and initially approved on 25th February 2015, for treating serious infections such as pneumonia, urinary tract infections, and abdominal infections.
Mechanism of Action of undefined
Ceftazidime is a cephalosporin antibiotic that inhibits bacterial cell wall synthesis, while Avibactam is a beta-lactamase inhibitor. Avibactam helps protect Ceftazidime from being degraded by beta-lactamase enzymes, allowing the antibiotic to kill the bacteria effectively.
Uses of undefined
Ceftazidime + Avibactam this combination is effective against a wide range of bacteria and is commonly used to treat serious infections such as pneumonia, urinary tract infections, and abdominal infections.
undefined Drug administaration and Dosage available
This injection is available with a dose of 2gm or 2gm/0.5gm. Do not self-administer the Ceftazidime + Avibactam injection. Your doctor will decide the duration and dose of your treatment based on the disease severity and other factors. It will be given as an intravenous infusion, and you will be monitored carefully for unwanted side effects.
Warnings, Precautions and Side Effects of undefined
This drug is contraindicated in individuals with known hypersensitivity or allergy to it or its component. Report your physician if you are allergic to any antibiotic group. You may develop fits-like symptoms if you consume too much Ceftazidime + Avibactam. Inform your doctor if you have a history of seizures or epilepsy. Use of this medication can lead to antibiotic-associated diarrhoea, which ranges from mild to severe. If you experience severe diarrhoea during or after treatment, inform your physician.
Ceftazidime + Avibactam should be used cautiously in individuals with impaired kidney function. Your doctor may need to adjust the dosage based on your kidney function and closely monitor your kidney health during treatment. Notify your physician if you are pregnant or breastfeeding. It is necessary to consult this with your physician for more advice.
The side effects known to occur commonly during the treatment with Ceftazidime + Avibactam are fever, headache, dizziness, itching, redness, or swelling in the injection site, stomach pain, nausea, vomiting, change in the number of certain types of blood cells, and fungal infections. Some serious side effects also include severe allergic reactions (swelling of lips, face, or throat, rash, difficulty swallowing or breathing), and severe or bloody diarrhoea.
Word Of Advice
Finish the entire prescribed course of Ceftazidime + Avibactam, even if you start feeling better before the completion. Stopping the medication suddenly can lead to incomplete treatment and the risk of recurrent or resistant infections. Notify your doctor if you have allergies to cephalosporin antibiotics, penicillins, or other medications. Also, report any adverse reactions or side effects you experience during treatment.
Frequently Asked Question
- Pfizer Limited, Electronic medicines compendium (EMC), [Revised on June 2022] [ Accessed on 26th June 2023], https://www.medicines.org.uk/emc/files/pil.2465.pdf
- Zavicefta, Annex I summary of Product Characteristics - European Medicines Agency. [ Accessed on 26th June 2023], https://www.ema.europa.eu/en/documents/product-information/zavicefta-epar-product-information_en.pdf
- Allergan USA, Inc, US Food and Drug Administration, [Revised on March 2019] [ Accessed on 14th March 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/206494s005,s006lbl.pdf
- KD Tripathi, Essentials of Medical Pharmacology, Antimicrobial drugs, 7th edition, 2013,728.
- Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Penicillins, Cephalosporins and other Beta-Lactam Antibiotics, 12th edition, 2011, 1498.
The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.