This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Cilnidipine + Chlorthalidone is an antihypertensive medication developed by the U.S. Food And Drug Administration for treating hypertension.

Mechanism of Action of undefined

Cilnidipine is a calcium channel blocker that relaxes blood vessels and helps the heart circulate blood more efficiently throughout the body. Chlorthalidone increases urine production to eliminate excess water and electrolytes from the body. It also works by relaxing blood arteries and boosting blood flow over time.

Uses of undefined

Cilnidipine + Chlorthalidone is used to treat hypertension. It is a chronic condition characterized by persistently high blood pressure levels. If the condition is left untreated or uncontrolled, it can increase the chance of cardiovascular problems, including heart attacks and strokes. This tablet is often prescribed when a single medication alone is ineffective in controlling blood pressure.

undefined Drug administaration and Dosage available

It is an orally available prescription drug. Your doctor will decide the duration and dose of the drug based on the disease condition and other factors. Always take a Cilnidipine + Chlorthalidone tablet as prescribed by your doctor. Take the tablet with or without food. Do not open, break, chew, or crush the tablet. Swallow the whole tablet with water.

Warnings, Precautions and Side Effects of undefined


Cilnidipine + Chlorthalidone should not be used in individuals with known hypersensitivity or allergic reactions to this drug or its components. This tablet is contraindicated in patients with aortic stenosis, which is the narrowing of the aortic valve in the heart. The medication can affect the normal functioning of the heart in this condition, and it should be avoided. If you have experienced heart failure following a heart attack, this drug should not be taken, and it is not suitable in such cases. 


You must inform your physician about any liver or kidney problems you have. Individuals with impaired liver or kidney function may require dose adjustments or alternative medications. Notify your physician if you are pregnant, breastfeeding, or planning to have a baby. Grapefruit juice and grapefruit should be avoided by individuals taking Cilnidipine + Chlorthalidone. Grapefruit and its juice contain compounds that can inhibit the action of the enzyme called CYP3A4, leading to raised levels of the medication in the bloodstream.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Cilnidipine + Chlorthalidone are hypokalaemia (low blood levels of potassium), hyperuricemia (increased blood levels of uric acid), rise in blood lipids, skin rash, loss of appetite, and upset stomach. Some serious side effects also include postural hypotension, urticaria, jaundice, and gastrointestinal distress.

Word Of Advice

Try to avoid missing doses. If you accidentally miss a dose, take it as soon as you remember. Unless your doctor advises, avoid exceeding the recommended dose or frequency of Cilnidipine + Chlorthalidone tablet. Regularly monitor your blood pressure at home to ensure the medications effectively control your blood pressure levels. Follow a balanced diet low in sodium (salt) and high in fruits, vegetables, and whole grains. Limit your intake of processed foods and alcohol.

Frequently Asked Question


  1. Alkem Laboratories Ltd, [Revised March 2017], [Accessed on 26th June 2023]
  2. Morningside Healthcare Ltd. Electronic Medicines Compendium (EMC), [Revised Sep 2020], [Accessed on 26th June 2023]
  3. Renata Ltd, [Revised on Oct 2020], [ Accessed on 26th June 2023]
  4. Casper Pharma LLC, US Food & Drug Administration, [Revised on April 2018], [ Accessed on 26th June 2023]
  5. D.E. Newby, N.R. Grubb, A. Bradbury, Cardiovascular disease, Davidson's Principles and Practice of Medicine, 22nd Edition, 2014, 525-641.
  6. KD Tripathi, Antihypertensive drugs, Essentials of Medical Pharmacology, 7th Edition, 2013, 559.


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.