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Written By
Sakshi Anil More
B. Pharm

Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:30 AM (IST)

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CILNIDIPINE,CHLORTHALIDONE
Last updated on 31 Mar 2026 | 09:30 AM (IST)
CILNIDIPINE,CHLORTHALIDONE
Background and Date of approval CILNIDIPINE,CHLORTHALIDONE
Cilnidipine + Chlorthalidone is an antihypertensive medication developed by the U.S. Food And Drug Administration for treating hypertension.
Uses of CILNIDIPINE,CHLORTHALIDONE
Cilnidipine + Chlorthalidone is used to treat hypertension. It is a chronic condition characterized by persistently high blood pressure levels. If the condition is left untreated or uncontrolled, it can increase the chance of cardiovascular problems, including heart attacks and strokes. This tablet is often prescribed when a single medication alone is ineffective in controlling blood pressure.
How is CILNIDIPINE,CHLORTHALIDONE administered?
It is an orally available prescription drug. Your doctor will decide the duration and dose of the drug based on the disease condition and other factors. Always take a Cilnidipine + Chlorthalidone tablet as prescribed by your doctor. Take the tablet with or without food. Do not open, break, chew, or crush the tablet. Swallow the whole tablet with water.
Side Effects of CILNIDIPINE,CHLORTHALIDONE
The common side effects that are likely to occur while you are on the treatment with Cilnidipine + Chlorthalidone are hypokalaemia (low blood levels of potassium), hyperuricemia (increased blood levels of uric acid), rise in blood lipids, skin rash, loss of appetite, and upset stomach. Some serious side effects also include postural hypotension, urticaria, jaundice, and gastrointestinal distress.
Warnings
Cilnidipine + Chlorthalidone should not be used in individuals with known hypersensitivity or allergic reactions to this drug or its components. This tablet is contraindicated in patients with aortic stenosis, which is the narrowing of the aortic valve in the heart. The medication can affect the normal functioning of the heart in this condition, and it should be avoided. If you have experienced heart failure following a heart attack, this drug should not be taken, and it is not suitable in such cases.Â
Precautions
You must inform your physician about any liver or kidney problems you have. Individuals with impaired liver or kidney function may require dose adjustments or alternative medications. Notify your physician if you are pregnant, breastfeeding, or planning to have a baby. Grapefruit juice and grapefruit should be avoided by individuals taking Cilnidipine + Chlorthalidone. Grapefruit and its juice contain compounds that can inhibit the action of the enzyme called CYP3A4, leading to raised levels of the medication in the bloodstream.
Word of Advice
Try to avoid missing doses. If you accidentally miss a dose, take it as soon as you remember. Unless your doctor advises, avoid exceeding the recommended dose or frequency of Cilnidipine + Chlorthalidone tablet. Regularly monitor your blood pressure at home to ensure the medications effectively control your blood pressure levels. Follow a balanced diet low in sodium (salt) and high in fruits, vegetables, and whole grains. Limit your intake of processed foods and alcohol.
Frequently Asked Questions
Q1.
Can I take Cilnidipine + Chlorthalidone tablet with low BP?
If you have low blood pressure (hypotension), taking Cilnidipine + Chlorthalidone tablets may decrease your blood pressure and cause dizziness, lightheadedness, fainting, or fatigue. Therefore, taking this drug if you have low blood pressure is generally not recommended unless specifically prescribed and closely monitored by your physician.
Q2.
How do Cilnidipine and Chlorthalidone work?
Cilnidipine works by relaxing the blood vessels, which helps lower blood pressure. It does this by blocking calcium channels, which reduces the influx of calcium into the smooth muscles of the blood vessels. Chlorthalidone increases sodium and water excretion through the kidneys, which reduces fluid volume and helps lower blood pressure.
Q3.
What are the common side effects of Cilnidipine and Chlorthalidone?
Common side effects of Cilnidipine and Chlorthalidone may include dizziness, hypokalaemia (low blood levels of potassium), hyperuricemia (increased blood levels of uric acid), rise in blood lipids, skin rash, loss of appetite, and upset stomach.
Q4.
Can Cilnidipine and Chlorthalidone be taken during pregnancy or breastfeeding?
These medications are not recommended during pregnancy or breastfeeding. It's important to discuss your pregnancy or breastfeeding plans with your doctor.Â
Q5.
Are there any dietary restrictions while taking Cilnidipine and Chlorthalidone?
While taking Cilnidipine and Chlorthalidone, following a balanced diet low in sodium (salt) is generally recommended. Excessive salt intake can counteract the blood pressure-lowering effects of these medications. Consult with your doctor for more advice.
Q6.
Can Cilnidipine and Chlorthalidone be used for other conditions besides hypertension?
The primary indication for the combination of Cilnidipine and Chlorthalidone is the treatment of hypertension. These medications are not prescribed for other conditions.
References
- Alkem Laboratories Ltd, [Revised March 2017], [Accessed on 26th June 2023] https://www.alkemlabs.com/pdf/adverse/Cilnikem%20CT.pdf
- Morningside Healthcare Ltd. Electronic Medicines Compendium (EMC), [Revised Sep 2020], [Accessed on 26th June 2023] https://www.medicines.org.uk/emc/files/pil.11982.pdf
- Renata Ltd, [Revised on Oct 2020], [ Accessed on 26th June 2023] https://renata-ltd.com/wp-content/uploads/2020/12/Cilma-Insert.pdf
- Casper Pharma LLC, US Food & Drug Administration, [Revised on April 2018], [ Accessed on 26th June 2023] https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/019574s016lbl.pdf
- D.E. Newby, N.R. Grubb, A. Bradbury, Cardiovascular disease, Davidson's Principles and Practice of Medicine, 22nd Edition, 2014, 525-641.
- KD Tripathi, Antihypertensive drugs, Essentials of Medical Pharmacology, 7th Edition, 2013, 559.
Disclaimer
The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.






