This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Cilnidipine + metoprolol contains an active component as Cilnidipine and metoprolol. Cilnidipine is a calcium channel blocker (CCB) that blocks calcium channels in blood vessels and the heart. It helps in lowering blood pressure. Metoprolol belongs to a class of medications known as beta-blockers. It decreases heart rate and reduces the force of contraction.

Mechanism of Action of undefined

Cilnidipine + metoprolol provides a synergistic therapeutic effect in managing hypertension. Cildipine, a calcium channel blocker, relaxes and dilates the blood vessels, reducing peripheral resistance and improving blood flow. Metoprolol, a beta blocker that reduces the heart rate and force of contraction, reduces the workload on the heart and further contributes to blood pressure reduction.

Uses of undefined

Cilnidipine + metoprolol helps control high blood pressure and prevent angina, heart attack, and stroke.

undefined Drug administaration and Dosage available

Cilnidipine + metoprolol can be administered orally in tablet form. The specific usage instructions may vary depending on the condition being treated and the form of the medication. Oral tablets are typically taken with water, as directed by the healthcare provider.

Warnings, Precautions and Side Effects of undefined


Cilnidipine + metoprolol are medications that come with potential risks and side effects. Patients taking these medications should be aware of possible adverse reactions, including dizziness, drowsiness, low blood pressure (hypotension), and heart rate changes. Abruptly stopping this medication can lead to withdrawal symptoms, and dose adjustments may be necessary for patients with kidney impairment. This medication can mask some typical signs and symptoms of hypoglycemia (low blood sugar) in diabetic patients, such as increased heart rate. It may rarely cause peripheral edema or swelling in the extremities, such as the legs and ankles. 


It is crucial to inform healthcare providers of any pre-existing medical conditions, allergies, or medications being taken to avoid potential interactions and complications. Regular monitoring and follow-up appointments are essential to ensure proper management and minimize risks associated with cilnidipine and metoprolol use. Patients with diabetes should be aware of this and take appropriate precautions. Patients should not drive or operate machinery if experiencing dizziness or drowsiness while on these medications. If any concerning symptoms occur, seek immediate medical attention and consult a healthcare professional for guidance on proper use and potential alternatives. Patients experiencing significant edema should consult their healthcare provider.

Side Effects

Cilnidipine + metoprolol may cause several common side effects. Cilnidipine can lead to peripheral edema (swelling of the extremities), headache, and dizziness. Metoprolol may cause fatigue, drowsiness, slow heart rate, and reduced exercise tolerance. Both medications can lead to low blood pressure, resulting in symptoms such as lightheadedness or fainting. Patients may also experience gastrointestinal disturbances, including nausea and stomach pain.

Word Of Advice

When taking Cilnidipine + metoprolol, patients should exercise caution. It is essential to adhere to the prescribed dosage and schedule the healthcare provider provides. Avoid sudden changes in position, as these medications may cause dizziness or lightheadedness, especially when standing up quickly. Patients with asthma, COPD, heart conditions, liver impairment, or diabetes should inform their healthcare provider as dose adjustments or alternative medications may be necessary. Regularly monitor blood pressure, heart rate, and liver function as the healthcare provider advises. 

Patients should consult their doctor before discontinuing or adjusting the medication, as abrupt discontinuation can lead to rebound effects. If experiencing any concerning side effects or symptoms, seek medical attention promptly. It's essential to communicate openly with the healthcare provider about any health concerns or changes in health status while on this medication to ensure safe and effective treatment.

Frequently Asked Question


  1. Pubchem, Cilnidipine, [Revised on 31/10/2022] [Accessed on 19/07/2023],
  2. Lionel H. Opie. Calcium channel blockers. Drugs for the heart. 8th Edition. 2013. Page- 88-89.
  3. Mukesh Madhukar Shete et al., Cilnidipine: Next Generation Calcium Channel Blocker [Revised on 26/4/2016] [Accessed on 19/07/2023]


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.