This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Cloxacillin  was initially approved by the United States Food and Drug Administration (FDA) on  March 31, 1962.

Mechanism of Action of undefined

Cloxacillin exerts its antibacterial effect by inhibiting bacterial cell wall synthesis. It belongs to the beta-lactam class of antibiotics and functions by binding to penicillin-binding proteins (PBPs) on the bacterial cell wall. This disrupts the cross-linking of peptidoglycan strands, essential for the structural integrity of the bacterial cell wall. As a result, the bacterial cell wall weakens, leading to cell lysis and the eventual death of the bacteria. This medication is particularly effective against certain strains of Staphylococcus aureus bacteria that produce beta-lactamase, an enzyme that can inactivate other penicillin antibiotics.

Uses of undefined

Cloxacillin is used in the treatment of skin and soft tissue infections, respiratory tract infections, bone and joint infections, and other conditions caused by penicillinase-producing bacteria.

undefined Drug administaration and Dosage available

Cloxacillin can be administered via injection by healthcare provider. The appropriate route of administration is determined based on factors such as infection severity and patient condition. Always follow healthcare provider guidance for the correct administration method and dosage of  this medication.

Warnings, Precautions and Side Effects of undefined


Many signs of allergic reaction, like rash, swelling, or difficulty breathing can occur while on Cloxacillin. Persistent severe diarrhea can also occur which can be  a signal of a dangerous.  gut infection. Rare blood disorders can occur while using this medication. Yellowing of the skin or eyes, dark urine, or abdominal pain might indicate liver problems. Stopping early this medication  can lead to incomplete treatment and antibiotic resistance.


If you notice unusual bleeding, bruising, or frequent infections, while using Cloxacillin inform your healthcare provider. Watch for new or worsening symptoms during treatment, as prolonged use might lead to secondary infections. Rapid swelling, difficulty breathing, and severe rashes need urgent medical attention. Those with kidney issues might need regular monitoring by the healthcare professional. Complete the full course of this medicationas prescribed by the health care professional.

Side Effects

Cloxacillin use may result in a range of side effects, including common ones like gastrointestinal disturbances (nausea, vomiting, diarrhea), skin reactions (rash, itching), and injection site reactions (IV use). Serious side effects includes severe allergic reactions (swelling, breathing difficulties), severe skin reactions (Stevens-Johnson syndrome), gastrointestinal effects (Clostridium difficile infection, severe diarrhea), liver impact (jaundice, enzyme changes), blood disorders (low blood cell counts), drug interactions, superinfections, kidney function changes, and potential dizziness/drowsiness.

Word Of Advice

Before starting Cloxacillin, inform your healthcare provider about any allergies, especially to antibiotics, and your complete medical history, including kidney or liver problems. Follow the prescribed dosage and complete the full course, even if symptoms improve. If you're pregnant, breastfeeding, or have diabetes, consult your healthcare provider before using this medication. Avoid excessive alcohol consumption and be cautious if driving or operating machinery, as dizziness or drowsiness might occur. Report any unusual or severe side effects promptly, such as rash or difficulty breathing. Individuals with renal or liver issues may need dosage adjustments, and elderly individuals require close monitoring for serious side effects. Be aware of potential drug interactions, and store this medication as instructed. By following these precautions, you can improve the safe and effective use of  this medication while minimizing potential risks.

Frequently Asked Question


  1. Jiangxi Xierkangtai Pharmaceutical Co., Ltd, US Food and Drug Administration, [Issued on 07th 2022] [Accessed on 16th August 2023],
  2. JB Bru et al, Role of intravenous Cloxacillin in inpatient infections, Med Mal Infect,[Published on 2012] [Accessed on 16th August 2023],
  3. J Loulerge; Changes in microbial ecology and use of cloxacillin; [Published on 1994] [Accessed on 16th August 2023],
  4. Victor Manuel Martinez Taboada; Cloxacillin based therapy in severe septic bursitis; [Published on 2009] [Accessed on 16th August 2021],


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.