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CYTOKINE REMOVAL

CYTOKINE REMOVAL

Background and Date of approval CYTOKINE REMOVAL

Cytokine removal is a medical device used in critical care settings to remove inflammatory mediators from the bloodstream of patients with conditions such as sepsis, acute respiratory distress syndrome (ARDS), and cardiac surgery-associated inflammatory response syndrome (CARS). The body can produce excessive levels of cytokines in inflammation due to severe infection. This device removes these cytokine substances in your blood. Cytosorb has received clearance from the FDA for marketing medical devices in the United States. The clearance was granted on September 1, 2011.

Uses of CYTOKINE REMOVAL

Cytokine removal uses in the treatment of COVID-19 patients with severe symptoms and acute respiratory distress syndrome (ARDS).

How is CYTOKINE REMOVAL administered?

Cytokine removal should only be used by qualified healthcare professionals and requires specialized medical training. It is a medical device used in critical care settings where a cartridge containing porous polymer beads is connected to the patient's circulation. Blood is circulated through the cartridge, and the inflammatory mediators are selectively adsorbed onto the surface of the beads.

Side Effects of CYTOKINE REMOVAL

Cytokine removal is generally considered safe, but like any medical treatment, it can cause side effects. Some of the common side effects of treatment include hypotension (low blood pressure), fever, bleeding, and thrombocytopenia (low platelet count). Serious adverse events such as sepsis, anaphylactic shock, and device-related complications like clotting or breakage may also occur, but these are rare.

Warnings

The use of Cytokine removal in patients who have an active infection or sepsis increases the risk of developing sepsis-induced coagulopathy (SIC), which can lead to excessive bleeding or clotting. The treatment may cause the release of cytokines, which are proteins that can trigger inflammation in the body. Patients with pre-existing inflammatory conditions, such as rheumatoid arthritis or inflammatory bowel disease, may be at increased risk of experiencing an exacerbation of their symptoms during treatment with this device. The use of this device in patients with implanted electronic medical devices, such as pacemakers or defibrillators, may interfere with the function of these devices. It may cause the depletion of certain electrolytes in the body, such as calcium or magnesium.

Precautions

During treatment with Cytokine removal, the patients should be closely monitored for signs of SIC. Patients who are at risk of electrolyte imbalances, such as those with kidney or liver disease, should be monitored closely during treatment. Patients with electronic devices in the body like pacemakers should be monitored closely during treatment to ensure that their medical devices are functioning properly. The safety and effectiveness of treatment in pediatric patients has not been established. The device should be used with caution in children, and only under the direction of a qualified pediatric specialist.

Word of Advice

If you are taking Cytokine removal treatment, it is important to discuss any concerns or questions you may have with your healthcare provider. Pregnant and breastfeeding women should discuss their risk and benefit with the doctor. Be sure to provide your doctor with a complete medical history, including any medications you are taking and any pre-existing medical conditions you may have. Always follow the dosing instructions and precautions provided by your doctor, and report any side effects or adverse reactions to your healthcare provider as soon as possible. Never stop or modify your medication regimen without consulting your healthcare provider.

Frequently Asked Questions

Q1.

Can Cytokine removal be reused or recycled?

No, Cytokine removal is a single-use medical device and should not be reused or recycled. Each device is intended for single-patient use and should be properly disposed of after treatment.

Q2.

Does Cytokine removal treatment have any effect on chemotherapy or radiation therapy?

No evidence suggests that Cytokine removal treatment interferes with chemotherapy or radiation therapy. However, patients undergoing cancer treatment should discuss the potential risks and benefits of treatment with their healthcare provider.

Q3.

Can Cytokine removal be used in children?

Yes, Cytokine removal can be used in children, although the dosing and administration may vary depending on the child's age and weight. Your child's healthcare provider will determine the appropriate dosing and treatment duration based on their medical needs.

Q4.

Can Cytokine removal be used in patients with kidney or liver disease?

Cytokine removal has been used in patients with kidney or liver disease and those with normal kidney and liver function. However, the safety and efficacy treatment in these patient populations may vary and depend on a case-by-case basis by a healthcare provider.

Q5.

Can Cytokine removal be used in patients with bleeding disorders?

Cytokine removal treatment may increase the risk of bleeding in some patients, particularly those with preexisting bleeding disorders or those taking blood-thinning medications. Patients with bleeding disorders should discuss the potential risks and benefits of treatment with their healthcare provider before undergoing treatment.

Q6.

Does Cytokine removal treatment require any special monitoring?

Patients undergoing Cytokine removal treatment may require special monitoring, including regular blood tests to monitor electrolyte levels and other indicators of organ function. Your healthcare provider will determine the appropriate monitoring schedule based on your medical needs.

Q7.

Can Cytokine removal be used in patients with heart failure or other cardiac conditions?

Cytokine removal may be used in patients with heart failure or other cardiac conditions, but the safety and efficacy of treatment in these populations may vary. Your healthcare provider will determine whether the treatment is appropriate for your medical needs.

References

  1. Cytosorbents, US Food and Drug Administration, [Updated on April 10 2020], [ Accessed on 27th Apri 2023], https://www.fda.gov/media/136866/download
  2. Dina Ragab et al; The COVID-19 Cytokine Storm; What We Know So Far; Frontiers in Immunology [Published on 16/06/2020], [27th April 2023] https://www.frontiersin.org/articles/10.3389/fimmu.2020.01446/full

Disclaimer

The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.

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