This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Dacomitinib is an anticancer agent belonging to the category of kinase inhibitors which was approved for its medical use in 2018.

Mechanism of Action of undefined

Dacomitinib Tablet is a biological agent that acts as targeted drug therapy in cancer treatment. It is classified under protein tyrosine kinase inhibitors. It has potent activity against EGFR genes (genes that are prominent in non-small cell lung cancer and some types of breast cancer undergoing mutation). On acting against EGFR genes, Dacomitinib interrupts cell signaling and arrests the growth of cancer cells.

Uses of undefined

Dacomitinib Tablet has been approved to treat non-small cell lung cancer that has spread to other organs.  

undefined Drug administaration and Dosage available

Dacomitinib is available as a film-coated tablet in the doses 15mg, 30mg and 45mg. The recommended dose is 45mg once a day with or without food. It is advisable to swallow the whole tablet and take them at the same time each day. Your healthcare provider may alter the dose depending on how well your body tolerates it.

Warnings, Precautions and Side Effects of undefined


 Contact your doctor immediately if you experience shortness of breath, fever, or severe diarrhea. During the Dacomitinib Tablet treatment, your doctor may periodically monitor your liver parameters to prevent serious complications. Report to your doctor if you have had a history of lung disease or other health problems. 


Discuss with your physician before starting this treatment if you are pregnant or planning to have a baby. Since Dacomitinib has the potential to harm an unborn baby, it is essential to use an effective contraceptive and continue till 17 days after completing the treatment to prevent unwanted pregnancy. Avoid breastfeeding your baby during this treatment as it is not known if Dacomitinib passes into the breast milk.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Dacomitinib Tablet are inflammation in the mouth and lips, skin problems, loss of appetite, weight loss, hair loss, nausea, vomiting, abnormal liver enzymes in blood tests, tiredness, weakness, abnormal body hair growth, etc. If you experience breathing difficulty, cough, fever, diarrhoea or skin rash, report to your doctor immediately.

Word Of Advice

Tiredness and eye irritation are pretty common occurrences in patients taking Dacomitinib Tablet. Hence, it is advisable to avoid driving or using machines during this treatment.

Frequently Asked Question


  1. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet], [Revised on Apr 2019] [Accessed on 10th Aug 2022],
  2. Pfizer Limited, Electronic Medicines Compendium (EMC), [Revised on Sep 2018] [Accessed on 10th Aug 2022],
  3. Pfizer, U.S. Food and Drug Administration, [Revised on Sep 2018] [Accessed on 10th Aug 2022],


The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.