Uses of undefined

Dactinomycin is used to treat different cancer disorders such as Wilms’ tumor (a type of kidney cancer that usually occurs in children, Ewing’ sarcoma (a type of bone cancer), melanoma (skin cancer), testicular and uterus cancer, Rhabdomyosarcoma (rare kind of cancer in muscle).  It works by inhibiting the reproduction cells (especially abnormal cells). 

undefined Drug administaration and Dosage available

Dactinomycin injection is administered as an intravenous infusion into the vein or directly into the cancer site. If this injection is recommended for you, it will be given by a healthcare professional. Do not self-administer. Your physician will choose the dosage and administration frequency based on the medical condition because it differs for each person.

Warnings, Precautions and Side Effects of undefined

Warnings

Do not take this medicine if you are allergic to Dactinomycin or its other ingredients if you have chickenpox or shingles. This medicine may cause kidney, liver, and bone marrow (myelosuppression) problems. So, report to your doctor if you have any underlying medical conditions. Before starting the treatment, inform your doctor if you are pregnant or planning to get pregnant or breastfeeding. Notify your doctor if you took any X-rays or antibacterial treatment. 

Precautions

Use effective contraception during and after the treatment; women for six months and men for three months even after the treatment. Discuss your fertility problem with the doctor since this medicine could cause fertility issues as its side effects.  Inform your physician about any underlying kidney disorders before taking Dactinomycin, as this medication should be used cautiously in kidney disease patients. If you spill or splash the medicine, it must be washed immediately and need medical action as this medicine can cause severe skin tissue damage. 

Side Effects

The most common side effects of Dactinomycin are nausea, vomiting, inflammation of the rectum, tiredness, feeling unwell, fertility problems, inflammation of the lungs, chest pain, difficulty swallowing, mouth ulcers, sore throat, cracked lips, tingling in hands and feet, difficulty in breathing with thoracic pain, stomach pain, ulcers, loss of appetite, blood clot, diarrhea, constipation, skin rashes, acne, increased darkness in the skin, hair loss, soft tissue damage, blurry vision. 

Serious side effects while taking Dactinomycin are bacterial infection in the bloodstream (shivering, diarrhea, sudden chill), severe bleeding, inflammation of the vein, facial or tongue swelling, skin and muscle pain accompanied by fever and chills, blisters covering a large portion of the body, peeling off the skin, red or purplish rash, tumor lysis syndrome (muscle spasm, decreased urine flow, irregular heartbeat), liver problems (difficulty breathing with thoracic pain, confusion, seizures, sweet breath odor), lower blood cells (RBC, WBC, platelet).

Word Of Advice

Store at a temperature below 25˚C. Do not refrigerate or freeze. Keep the vials away from direct sunlight. Keep this medicine out of sight and reach of children. If you missed your dose, visit your doctor once after you remember. 

Frequently Asked Question

• Why do I feel numbness and tingling while taking Dactinomycin?
• Dactinomycin can damage these nerves, leading to numbness, tingling, or a burning sensation in the hands and feet. If you are experiencing this while taking this treatment, it is important to inform your doctor. 

• How is Dactinomycin dosage determined? 
• Dactinomycin dosage is based on several factors, including the type and stage of the cancer being treated, the individual's overall health, and their response to the treatment. 

• What is the precaution for Dactinomycin? 
• Inform your doctor if you have any underlying medical conditions with kidney, liver, or bone marrow. Notify your doctor if you are pregnant or planning to get pregnant or breastfeeding.  

• When should I use contraception? During or after the treatment? 
• It is advised to use during and after the treatment of Dactinomycin. Women should use six months; for men, it's three months after the last dose.  

• Does Dactinomycin cause any side effects to the eyes? 
• Blurring eyes is one of the most common side effects of eyes with Dactinomycin. If you experience any side effects, contact your doctor immediately.