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Written By
P. Thirumal Reddy
B. Pharm
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:31 AM (IST)
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Quick Summary
DARUNAVIR,RITONAVIR
Last updated on 31 Mar 2026 | 09:31 AM (IST)
DARUNAVIR,RITONAVIR
Darunavir, Ritonavir is a combination regimen consisting of antiviral medications, which was approved for its medical use on 23rd June 2006.
Darunavir, Ritonavir has been developed to treat Human Immunodeficiency Virus (HIV-1). Darunavir, Ritonavir Tablet is indicated as a complete regimen for treating adults and children older than 3 years of age, infected with HIV 1.
Darunavir, Ritonavir is available as film coated tablets consisting of 600mg of Darunavir and 100mg of Ritonavir. The usual recommended dosage of this combination regimen is one tablet everyday with or without food.
The common side effects that are likely to occur while you are on the treatment with Darunavir, Ritonavir Tablet are diarrhoea, nausea, rash, headache, stomach pain, vomiting, changes in taste, dizziness, weakness, tiredness, loss of appetite and tingling sensation. If you experience any allergic reactions after taking this tablet, report to your doctor immediately.
Warnings
Do not take this medication if you have experienced hypersensitivity reactions to Darunavir, Ritonavir or any of its ingredients. Patients who are diagnosed with pancreatitis or at risk of pancreatitis should take this combination medicine with caution. During the treatment with Darunavir, Ritonavir combination, your doctor may periodically monitor your blood counts, bone mineral density, liver and kidney parameters to prevent serious complications. Report to your doctor if you have been diagnosed with heart failure, pancreatitis, haemophilia, bone disease, fractures, hepatitis B, hepatitis C, liver or kidney problems.Â
Precautions
Adults of childbearing potential should consider using an effective contraceptive to prevent unwanted pregnancy. Tell your doctor before starting this treatment if you are pregnant or planning to have a baby. Breastfeeding is not recommended due to potential transmission of HIV from mother to the baby.
Word of Advice
Darunavir, Ritonavir can make you feel dizzy and tired. Hence, you should avoid driving or handling machines during this treatment.Â
Frequently Asked Questions
Q1.
hat should you do if you missed a dose of Darunavir, Ritonavir Tablet?
If you miss a dose of Darunavir, Ritonavir Tablet, take one as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with the scheduled dose. Do not take two doses to make up for the missed dose.
Q2.
What should you know about using contraceptives while on treatment with Darunavir, Ritonavir?
Darunavir and Ritonavir reduce the efficacy of oral and patch contraceptives. Discuss alternative methods of contraception with your physician to prevent unwanted pregnancy.
Q3.
When should you report to your healthcare provider?
Reach out to your healthcare provider if you notice unusual blisters, extreme tiredness, yellowing of skin or eyes, mouth sores, dark urine, fever or conjunctivitis.
Q4.
What are the required laboratory parameters prior to starting this treatment?
If you are an adolescent or adult of childbearing potential, your healthcare provider will perform a pregnancy test before prescribing this treatment. Other prominent tests include test for HBV infection, blood sugar levels, liver and kidney parameters.
Q5.
Does treatment with Darunavir, Ritonavir cause diabetes?
Darunavir, Ritonavir Tablet leads to increase in blood glucose and the new onset of diabetes. Tell your physician if you notice extreme thirst or urination during this treatment.
Q6.
How to store Darunavir, Ritonavir Tablets?
Store Darunavir, Ritonavir Tablets at room temperature, away from the reach of children. Store the tablets in the original container and protect from heat.
Q7.
What are the long-term side effects of treatment with Darunavir, Ritonavir Tablet?
Some long-term side effects associated with Darunavir, Ritonavir Tablet are immune reconstitution syndrome, diabetes and increased amount of body fat.
References
1. Janssen Pharmaceuticals, [Revised on Apr 2022] [Accessed on 30th Sep 2022], https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/PREZISTA-pi.pdf
2. AbbVie Corporation, [Revised on 5th Jul 2021] [Accessed on 30th Sep 2022], https://www.abbvie.ca/content/dam/abbvie-dotcom/ca/en/documents/products/NORVIR_PM_EN.pdf
3. KD Tripathi, Antiviral Drugs (Anti-retrovirus), Essentials of Medical Pharmacology, 8th Edition, 2019, 860-872.
4. Capetti et al., A dual regimen of ritonavir/darunavir plus dolutegravir for rescue or simplification of rescue therapy: 48 weeks’ observational data, BMC Infectious Diseases (2017) 17:658, https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/s12879-017-2755-4.pdf
Disclaimer
The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.
