This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Background and Date of Approval
Darunavir, Ritonavir is a combination regimen consisting of antiviral medications, which was approved for its medical use on 23rd June 2006.
Mechanism of Action of undefined
Darunavir, Ritonavir Tablet is an antiviral combination of medicine that belongs to the category of protease inhibitors. The protease enzyme forms the final protein structure of the HIV. Darunavir and Ritonavir works by inhibiting the action of protease enzymes and leads to the formation of HIV proteins with poor morphology. This, in turn, stops the replication of the virus.
Uses of undefined
Darunavir, Ritonavir has been developed to treat Human Immunodeficiency Virus (HIV-1). Darunavir, Ritonavir Tablet is indicated as a complete regimen for treating adults and children older than 3 years of age, infected with HIV 1.
undefined Drug administaration and Dosage available
Darunavir, Ritonavir is available as film coated tablets consisting of 600mg of Darunavir and 100mg of Ritonavir. The usual recommended dosage of this combination regimen is one tablet everyday with or without food.
Warnings, Precautions and Side Effects of undefined
Do not take this medication if you have experienced hypersensitivity reactions to Darunavir, Ritonavir or any of its ingredients. Patients who are diagnosed with pancreatitis or at risk of pancreatitis should take this combination medicine with caution. During the treatment with Darunavir, Ritonavir combination, your doctor may periodically monitor your blood counts, bone mineral density, liver and kidney parameters to prevent serious complications. Report to your doctor if you have been diagnosed with heart failure, pancreatitis, haemophilia, bone disease, fractures, hepatitis B, hepatitis C, liver or kidney problems.
Adults of childbearing potential should consider using an effective contraceptive to prevent unwanted pregnancy. Tell your doctor before starting this treatment if you are pregnant or planning to have a baby. Breastfeeding is not recommended due to potential transmission of HIV from mother to the baby.
The common side effects that are likely to occur while you are on the treatment with Darunavir, Ritonavir Tablet are diarrhoea, nausea, rash, headache, stomach pain, vomiting, changes in taste, dizziness, weakness, tiredness, loss of appetite and tingling sensation. If you experience any allergic reactions after taking this tablet, report to your doctor immediately.
Word Of Advice
Darunavir, Ritonavir can make you feel dizzy and tired. Hence, you should avoid driving or handling machines during this treatment.
Frequently Asked Question
1. Janssen Pharmaceuticals, [Revised on Apr 2022] [Accessed on 30th Sep 2022], https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/PREZISTA-pi.pdf
2. AbbVie Corporation, [Revised on 5th Jul 2021] [Accessed on 30th Sep 2022], https://www.abbvie.ca/content/dam/abbvie-dotcom/ca/en/documents/products/NORVIR_PM_EN.pdf
3. KD Tripathi, Antiviral Drugs (Anti-retrovirus), Essentials of Medical Pharmacology, 8th Edition, 2019, 860-872.
4. Capetti et al., A dual regimen of ritonavir/darunavir plus dolutegravir for rescue or simplification of rescue therapy: 48 weeks’ observational data, BMC Infectious Diseases (2017) 17:658, https://bmcinfectdis.biomedcentral.com/counter/pdf/10.1186/s12879-017-2755-4.pdf
The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.