This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Dinoprostone is a uterotonic drug developed by the U.S. Food And Drug Administration and initially approved for treating labor in pregnant women.

Mechanism of Action of undefined

Dinoprostone works by binding to specific receptors on the uterine muscle cells, leading to an increase in contractions and softening of the cervix. This helps to initiate labor or prepare the cervix for childbirth.

Uses of undefined

Dinoprostone is used to induce labor in pregnant women. It facilitates cervical ripening and manages certain pregnancy-related complications. It is a synthetic form of prostaglandin E2, a hormone that influences uterine contractions and cervical changes.

undefined Drug administaration and Dosage available

Dinoprostone gel is administered intravaginally for the purpose of cervical ripening or labor induction. Using a sterile applicator, the physician gently inserts the gel into the patient's vagina and places it close to the cervix. After application, the patient is monitored for some time.

Warnings, Precautions and Side Effects of undefined


Before receiving Dinoprostone, it's important to inform your physician about any allergies, sensitivities,  existing heart, lung, kidney, or liver disease, previous uterine surgeries, or cesarean sections in your medical history, as well as any ongoing use of medications, supplements, or herbal products. This information will help ensure the safe and effective use of the medication for your specific situation. 


This medicine can only be given in the later stages of pregnancy to induce labour. Consult your doctor for more advice. While this drug is found in breast milk, it poses no harm to your baby. Therefore, you can continue breastfeeding without concern after childbirth.

Side Effects

The side effects known to occur commonly during the treatment with Dinoprostone are uterine contractions, abdominal pain, nausea and vomiting, diarrhea, headache, and changes in blood pressure. Some serious side effects include severe abdominal pain, heavy vaginal bleeding, and signs of an allergic reaction (swelling, rash, itching, difficulty breathing).

Word Of Advice

Dinoprostone can cause uterine contractions, which are necessary for labor but could potentially be harmful if used inappropriately. It's necessary to ensure that the medication is administered correctly to avoid excessive contractions or complications.

Frequently Asked Question


  1. Pfizer, Electronic medicines compendium (EMC), [ Revised on June 2021] [ Accessed on 26th August 2023],
  2. Pfizer, US Food and Drug Administration, [ Revised on Feb 2010] [ Accessed on 26th August 2023],
  3. KD Tripathi, Essentials of Medical Pharmacology, Prostaglandins, Leukotrienes and Platelet-activating factor, 7th edition, 2013, 189.
  4. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Contraception and Pharmacotherapy of Obstetrical, 12th edition, 2011, 1850.


The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.