This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Diphtheria toxoid, Pertussis toxoid, and Tetanus toxoid combination is a vaccine used to prevent diphtheria, pertussis, and tetanus infections. In 1981, the U.S. FDA approved this combination for use in immunisation programs.

Mechanism of Action of undefined

The Diphtheria toxoid, Pertussis toxoid, and Tetanus toxoid combination works by introducing inactivated forms of the toxins that cause these diseases. This stimulates the immune system to produce antibodies without causing illness. If the body encounters the actual bacteria in the future, the immune system is prepared to fight off the infection more effectively.

Uses of undefined

The Diphtheria toxoid, Pertussis toxoid, and Tetanus toxoid combination is used to protect individuals, particularly children, from three serious infectious diseases: diphtheria, pertussis (whooping cough), and tetanus. It is typically administered as part of routine childhood vaccination schedules. The vaccine helps the body develop immunity against these diseases, which can cause severe complications or even death. Booster doses are recommended for continued protection throughout life.

undefined Drug administaration and Dosage available

The Diphtheria toxoid, Pertussis toxoid, and Tetanus toxoid combination is typically administered as an intramuscular injection by a healthcare provider. For children, it is usually given as part of a series of doses, starting at 2 months of age, with additional booster doses as recommended by national immunisation schedules. In adults, booster shots may be administered every 10 years to maintain immunity. The injection is often given in the upper arm or thigh, depending on the patient’s age.

Warnings, Precautions and Side Effects of undefined

Warnings

  • Allergic Reactions: Do not administer the vaccine to individuals with a known allergy to any component of the vaccine or a history of severe allergic reactions (anaphylaxis) to previous doses.
  • Neurological Reactions: Exercise caution when administering to individuals with a history of severe neurological disorders, such as encephalopathy or seizures, as the vaccine may trigger similar reactions.
  • Pregnancy: Avoid administering the vaccine during pregnancy unless deemed absolutely necessary by a healthcare provider, as its safety during pregnancy has not been fully established.
  • Acute Illness: Do not administer the vaccine to individuals with moderate or severe acute illness or infection, as it may interfere with the body's immune response.
  • Pertussis Component Caution: Be cautious when giving the pertussis component to children with a history of severe reactions to previous doses, including persistent crying, fever, or seizures.
  • Apnea in Premature Infants: Apnea (a temporary cessation of breathing) can occur in premature infants after vaccination, so special care should be taken when administering the vaccine to preterm babies.

Precautions

Precautions for Diphtheria toxoid, Pertussis toxoid, and Tetanus toxoid combination include caution in individuals with a history of severe reactions to previous doses, those with weakened immune systems, or premature infants. If a child or infant has a history of seizures, antipyretics should be given to manage fever. It is important to consult a healthcare provider before administering the vaccine during pregnancy or breastfeeding, and special care should be taken for infants with a history of neurological disorders.

Side Effects

Side effects are unwanted symptoms caused by medicines. Although all drugs can cause side effects, not everyone experiences them.

Common side effects of Diphtheria toxoid, Pertussis toxoid, and Tetanus toxoid:

  • Pain, redness, or swelling at the injection site
  • Fever
  • Irritability or fussiness (especially in children)
  • Fatigue or tiredness
  • Loss of appetite
  • Mild rash

Serious side effects of Diphtheria toxoid, Pertussis toxoid, and Tetanus toxoid:

  • Severe allergic reaction (anaphylaxis), causing difficulty breathing or swelling of the face and throat
  • High fever (above 40°C/104°F)
  • Persistent crying or convulsions (in infants and young children)
  • Seizures
  • Difficulty swallowing or breathing

Word Of Advice

It is important to follow the recommended vaccination schedule for Diphtheria toxoid, Pertussis toxoid, and Tetanus toxoid to ensure proper protection against these serious diseases. Always consult with a healthcare provider before vaccination, especially if there is a history of allergic reactions or underlying health conditions. Keep track of booster doses to maintain long-term immunity. If you have concerns or notice unusual reactions after vaccination, seek medical advice promptly.

Frequently Asked Question

References

1. https://www.ncbi.nlm.nih.gov/books/NBK190028/

2. https://www.ncbi.nlm.nih.gov/books/NBK545173/

3. Liang JL, Tiwari T, Moro P, Messonnier NE, Reingold A, Sawyer M, Clark TA. Prevention of Pertussis, Tetanus, and Diphtheria with Vaccines in the United States: Recommendations of the Advisory Committee on Immunization Practices (ACIP). https://pmc.ncbi.nlm.nih.gov/articles/PMC5919600/

4. Harris G, Nolan T, Hartman L. Clinical signs associated with Triple Antigen (DTP) vaccination in infants. https://pubmed.ncbi.nlm.nih.gov/7669385/

Disclaimer

The drug information on this page is not a substitute for medical advice. It is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.